| Ernest Leng & SON Ltd | Construction | 2006 |
| Ernie and Stanley Limited | Professional & scientific | 2025 |
| ERP Service Ltd | Construction | 2016 |
| ERP Training Solutions Ltd. | Information & communication | 2016 |
| ES Rights Limited | Information & communication | 2006 |
| ES2PM Limited | Construction | 2026 |
| Escape Software Solutions Limited | Information & communication | 2008 |
| Escape to Unwind Limited | Real estate | 2022 |
| Eschools Holdings Limited | Financial services | 2017 |
| Eschools Limited | Information & communication | 2009 |
| Escrick Club CIC | Hospitality | 2025 |
| Escrick Commercial Consultancy Limited | Professional & scientific | 2024 |
| Escrick Developments Limited | Construction | 2009 |
| Escrick Environmental Services Limited | Construction | 2006 |
| Escrick Park Developments LLP | | 2024 |
| Escrick Street Management Company Limited | Households | 1991 |
| Eshawan Enterprise Limited | Real estate | 2007 |
| ESJ Commercial Services Ltd | Wholesale & retail | 2020 |
| ESK Valley Partnership (Sleights) LLP | | 2025 |
| Espada Boutique Limited | Wholesale & retail | 2016 |
| Esphy Limited | Information & communication | 2012 |
| Espresso Garden Ltd | Manufacturing | 2019 |
| Esprit Simulation Products Ltd | Manufacturing | 2022 |
| Esre Investments Ltd | Financial services | 2015 |
| Essencecatering Limited | Hospitality | 2024 |
| Essential York Limited | Hospitality | 2025 |
| Essex PC1 Limited | Extraterritorial | 2006 |
| Essex Pet Crematorium Limited | Extraterritorial | 2004 |
| Estomax Ltd | Wholesale & retail | 2005 |
| Esvima Limited | Real estate | 2025 |
| ET Distribution Ltd | Wholesale & retail | 2025 |
| Etaj Properties Ltd | Real estate | 2025 |
| Eternal Squares Ltd | Wholesale & retail | 2024 |
| Eternalts Limited | Wholesale & retail | 2015 |
| Etharius Limited | Information & communication | 2005 |
| Ethel Starkey Properties Ltd | Extraterritorial | 2024 |
| Ether/Awe Productions Ltd | Information & communication | 2018 |
| Ethical Apothecary Ltd | Wholesale & retail | 2017 |
| Ethical Procurement Ltd | Wholesale & retail | 1999 |
| Ethicco Limited | Wholesale & retail | 2012 |
| Ethos Properties Limited | Real estate | 2007 |
| Ethos Smart Homes Limited | Construction | 2019 |
| ETI Europe Limited | Other services | 2024 |
| Eticoll Ltd | Wholesale & retail | 2024 |
| ETL Fluid Experts Limited | Manufacturing | 2016 |
| Eton Court (Harrogate) Management Company Limited | Real estate | 2003 |
| Eton Place (Bracknell) Management Company Limited | Households | 2018 |
| ETS Civil Engineering Ltd | Construction | 2016 |
| Ettrickhall Limited | Water & waste | 2010 |
| Etty Farms Limited | Agriculture & fishing | 2023 |
| Ettyvine Ltd | Construction | 2024 |
| EU Building and Joinery Ltd | Construction | 2021 |
| EU Juicers Limited | Wholesale & retail | 2019 |
| Eukhost Ltd | Information & communication | 2005 |
| Eunoia Beauty Ltd | Other services | 2021 |
| Eurobiz Management Consultants Limited | Other services | 1994 |
| Eva's York Letting Ltd | Real estate | 2025 |
| Evalor Accounting Partners Ltd | Professional & scientific | 2017 |
| Evalor Invoicing Ltd | Administrative & support | 2025 |
| Evalor Ltd | Financial services | 2025 |
| Evans & Speight Bookkeeping Services Limited | Professional & scientific | 2022 |
| Evap Environmentals Limited | Administrative & support | 1997 |
| EVE Parc (Falmouth) Management Company Limited | Households | 2019 |
| Evela Stays Ltd | Hospitality | 2026 |
| Event Bro's Ltd | Hospitality | 2024 |
| Event COORDIN8 Limited | Arts & recreation | 2016 |
| Event Mobiles Ltd | Wholesale & retail | 2018 |
| Eventide Inks Ltd | Arts & recreation | 2023 |
| Eventus Financial Solutions Ltd | Financial services | 2014 |
| Eventus Hair Ltd | Other services | 2025 |
| Evergreen Atlas Capital Ltd | Financial services | 2026 |
| Evergreen Dairy Ltd | Hospitality | 2014 |
| Evergreen Exploring Ltd | Wholesale & retail | 2024 |
| Everingham Farms Limited | Real estate | 2022 |
| Everingham Place (Cantley) Residents Management Company Limited | Households | 2024 |
| Everlasting Memory Keepsakes Ltd | Manufacturing | 2023 |
| Everlong Developments Ltd | Construction | 2023 |
| Every Child (Achieving Their Potential) | Education | 2017 |
| Every Mile Software Ltd | Information & communication | 2026 |
| Everything Possible CIC | Education | 2011 |
| Everything Towelling.Com Limited | Manufacturing | 2014 |
| Everythinggreen Ltd | Wholesale & retail | 2022 |
| Evexias Health Ltd | Health & social care | 2022 |
| Evidax Ltd | Professional & scientific | 2026 |
| Evidence and Change Ltd | Construction | 2015 |
| Evidence Forward Ltd. | Professional & scientific | 2022 |
| Evigorate Limited | Information & communication | 2006 |
| Evil & Co. Meadworks Ltd | Manufacturing | 2025 |
| Evin Duman Ltd | Other services | 2020 |
| Evistrat Consulting Limited | Professional & scientific | 2024 |
| Evoke Hosting Ltd | Information & communication | 2022 |
| Evolution Electrical York Ltd | Construction | 2020 |
| Evolution Joinery Ltd | Construction | 2024 |
| Evolution Sports Academy Ltd | Education | 2020 |
| Evolve (Hairdressing) York Ltd | Other services | 2011 |
| EVOLVE123 Ltd | Real estate | 2023 |
| Evolved Bookkeeping Ltd | Professional & scientific | 2019 |
| Evolving Leadership (EL) Ltd | Professional & scientific | 2004 |
| Evolving Roots CIC | Education | 2024 |
| Ewams Ltd | Professional & scientific | 2022 |