| DOL YR Ysgol (Bridgend) Management Company Limited | Households | 2016 |
| Dolenc Ltd | Professional & scientific | 2014 |
| Doll Smash Cosmetics Limited | Manufacturing | 2020 |
| Dolly's Vegan Bakery Ltd | Manufacturing | 2025 |
| Dollybirds Boutique UK Ltd | Wholesale & retail | 2024 |
| Dolphin Minerals Limited | Wholesale & retail | 2021 |
| Dolphin Mobility Yorkshire + Cumbria Ltd | Wholesale & retail | 2009 |
| Dolphin RHB Holdings Ltd | Hospitality | 2025 |
| Domestic Divas East Coast & Country Ltd | Administrative & support | 2020 |
| Domestic Divas Holdings Limited | Extraterritorial | 2015 |
| Domestic Divas Wetherby Ltd | Administrative & support | 2017 |
| Domestic Divas York Limited | Administrative & support | 2013 |
| Dominate Holdings Ltd | Administrative & support | 2025 |
| Dominic Gregory Limited | Hospitality | 2025 |
| Dominus Fitness Limited | Arts & recreation | 2015 |
| Domus Group Limited | Extraterritorial | 1946 |
| DON Green (Farms) Ltd. | Agriculture & fishing | 1992 |
| Don's Cleaning Solutions Ltd | Administrative & support | 2023 |
| Donato Digital Ltd | Information & communication | 2025 |
| Donc Onyva Limited | Real estate | 2026 |
| Doncaster Racing Limited | Arts & recreation | 2014 |
| Dood Limited | Financial services | 2025 |
| Dookkii Limited | Wholesale & retail | 2018 |
| Doozi Investment Company Ltd | Extraterritorial | 2006 |
| Doqex Limited | Information & communication | 2013 |
| Dorchester House Management Limited | Households | 2006 |
| Dorell Holdings Ltd | Real estate | 2023 |
| Dorlux Beds Limited | Administrative & support | 2011 |
| Dorlux Limited | Administrative & support | 2011 |
| Dorricott Ward Recruitment Limited | Administrative & support | 2020 |
| Dorrington Construction Limited | Construction | 2008 |
| DOT Info Ltd | Information & communication | 2025 |
| Dotdot Pet Care Ltd | Other services | 2024 |
| Double Dutch Pancake House Limited | Hospitality | 2015 |
| Double SIX Developments Limited | Real estate | 2014 |
| Doubs Ltd | Wholesale & retail | 2022 |
| Douc Limited | Manufacturing | 2024 |
| Doug & Co (York) Ltd | Wholesale & retail | 2024 |
| Douga Ltd | Information & communication | 2025 |
| Dough (York) Ltd | Wholesale & retail | 2025 |
| Dough Disciples Ltd | Hospitality | 2020 |
| Doughty & SON Engineering Ltd | Manufacturing | 2019 |
| Doughty Legal Limited | Professional & scientific | 2024 |
| Dougie Costello Limited | Arts & recreation | 2007 |
| Douglas Meadow (Adlington) Management Company Limited | Households | 2016 |
| Dove Court (Easingwold) Management Company Limited | Administrative & support | 2010 |
| Dove Studios Ltd | Professional & scientific | 2026 |
| Dove Valeting Ltd | Wholesale & retail | 2020 |
| Dovecote Investments Limited | Other services | 2006 |
| Dovecreation UK Ltd | Information & communication | 2025 |
| Dovetail Sensory Ltd | Wholesale & retail | 2026 |
| Dowden Financial Services Ltd | Financial services | 2026 |
| Dower House Freehold Management Company Limited | Households | 2012 |
| Dowling Media and Hospitality Recruitment Ltd | Information & communication | 2025 |
| Down the Line Tennis Consultancy Ltd | Education | 2019 |
| Dowson Joinery Limited | Professional & scientific | 2006 |
| DP Advanced GI Solutions Ltd | Health & social care | 2026 |
| DP Complete Housing Ltd | Real estate | 2025 |
| DP Complete Plumbing Ltd | Construction | 2024 |
| DP Construction & Joinery Ltd | Construction | 2025 |
| DP Martin Commercial Management Ltd | Professional & scientific | 2020 |
| DPB Homecover Ltd | Construction | 2023 |
| DPB Plumbing & Heating Engineers Ltd | Construction | 2019 |
| DPC Racing Ltd | Wholesale & retail | 2020 |
| DPF Electrical Ltd | Construction | 2024 |
| DPG Defenders Limited | Extraterritorial | 2014 |
| Dpta Guiseley Ltd | Arts & recreation | 2023 |
| DR Aimee Moss Aesthetics Limited | Health & social care | 2025 |
| DR DAN Leeder Limited | Health & social care | 2021 |
| DR Elizabeth Garthwaite Ltd | Health & social care | 2023 |
| DR Francis Eyre Ltd | Professional & scientific | 2015 |
| DR Hummad Choudhry Limited | Health & social care | 2025 |
| DR JKD Ltd | Health & social care | 2024 |
| DR Karan Teaching Limited | Health & social care | 2025 |
| DR Kirsty Kennedy Limited | Professional & scientific | 2019 |
| DR Locks Ltd. | Other services | 2018 |
| DR M B Lewis Ltd | Health & social care | 2019 |
| DR Michael Holmes Ltd | Professional & scientific | 2014 |
| DR Prawash Dentistry Limited | Health & social care | 2024 |
| DR Private Travel Ltd | Administrative & support | 2023 |
| DR RGX Ltd | Health & social care | 2024 |
| DR ROB Anderson Limited | Health & social care | 2012 |
| DR Sagar Masani Limited | Health & social care | 2024 |
| DR Sarah Oliver Limited | Health & social care | 2021 |
| DR Susan Bradbury LLP | | 2007 |
| DR Woodside Facial Aesthetics Limited | Health & social care | 2016 |
| DR. Mannan & Associates Ltd | Health & social care | 2026 |
| Dr.Tariq Ltd | Health & social care | 2025 |
| Dragon House Chinese Ltd | Hospitality | 2025 |
| DRAGONBYTE3D Ltd | Wholesale & retail | 2025 |
| Dragonfly Holiday Lets Ltd | Hospitality | 2019 |
| Dragzed Ltd | Real estate | 2026 |
| Drains UK 2000 (Lining) Ltd | Water & waste | 2014 |
| Drains UK 2000 Limited | Water & waste | 2023 |
| Drake Street Management Company Limited | Households | 2025 |
| Drakes Garage (Shiptonthorpe) Limited | Wholesale & retail | 1992 |
| Drakes Garage Limited | Wholesale & retail | 2005 |
| Drakes Garage Recovery Ltd | Transport & logistics | 2008 |
| Dray Turner Ltd | Hospitality | 2024 |
| DRC Automotive Solutions Limited | Wholesale & retail | 2024 |