| Denville Holdings Limited | Administrative & support | 2025 |
| Denyer Estates LLP | | 2022 |
| DEP Electrical Services Limited | Construction | 2024 |
| Department of Colour Limited | Manufacturing | 2025 |
| Depth Charge Design & Print Ltd | Manufacturing | 2015 |
| Derby One Radio Ltd | Information & communication | 2025 |
| Derrings Ltd | Other services | 2015 |
| Derventio Limited | Wholesale & retail | 1991 |
| Derwent 1967 Limited | Extraterritorial | 2013 |
| Derwent Construction Limited | Construction | 2003 |
| Derwent Court Flats Limited | Real estate | 1983 |
| Derwent Court Management Company Limited | Households | 2002 |
| Derwent EA Ltd | Professional & scientific | 2019 |
| Derwent Electricals (North Yorkshire) Limited | Real estate | 1982 |
| Derwent Interiors Ltd | Wholesale & retail | 2026 |
| Derwent Mortgages Limited | Financial services | 2012 |
| Derwent Plumbing Ltd | Construction | 2006 |
| Derwent Shipping & Logistics Limited | Transport & logistics | 2010 |
| Derwent Signalling Testing Services Limited | Professional & scientific | 2018 |
| Derwenthorpe Community Interest Company | Administrative & support | 2025 |
| Derwenthorpe Flooring Limited | Construction | 2020 |
| Design by Hummingbird Limited | Wholesale & retail | 2014 |
| Design City Ltd | Professional & scientific | 2014 |
| Design Dwell Limited | Construction | 2020 |
| Design LED Intelligent Spaces Ltd | Professional & scientific | 2025 |
| Designbeau Studio Ltd. | Professional & scientific | 2020 |
| Designition Limited | Information & communication | 2004 |
| Designplay Ltd | Professional & scientific | 2013 |
| Desire Food Ltd | Wholesale & retail | 2025 |
| Desjan Ltd | Hospitality | 2025 |
| Desk Eleven Limited | Professional & scientific | 2024 |
| Desta Structures Limited | Manufacturing | 2025 |
| DEV Co Clothing Limited | Wholesale & retail | 2026 |
| Developing Business Excellence Limited | Professional & scientific | 2018 |
| Development Property and Land Limited | Agriculture & fishing | 2009 |
| Developmental Horizons Ltd | Health & social care | 2022 |
| Devillamar Group Limited | Financial services | 2026 |
| Devon Equine Vets Limited | Professional & scientific | 2014 |
| Devonshire Estate Holdings LLP | | 2015 |
| Devonshire Group Holdings Limited | Financial services | 2021 |
| Devonshire Land Limited | Construction | 2015 |
| Devonshire Square Properties Limited | Real estate | 2014 |
| Devonshire Yard Properties Limited | Real estate | 2021 |
| DEW Medical Aesthetics Ltd | Health & social care | 2024 |
| Dewhurst Foods Limited | Professional & scientific | 2015 |
| Dewhurst the Butcher Limited | Professional & scientific | 2015 |
| Dewlon Development Co. (Holdings) Limited | Professional & scientific | 2006 |
| Dewlon Development Co. Limited | Real estate | 1996 |
| Dexlyn York Ltd | Financial services | 2013 |
| Dexter Watson Limited | Manufacturing | 2012 |
| Dextra Holdings Limited | Financial services | 2021 |
| DF Silo Construction Ltd | Construction | 2024 |
| DFR Data Ltd | Information & communication | 2017 |
| DG European Ltd | Transport & logistics | 2022 |
| DG Heating Solutions Ltd | Construction | 2022 |
| Dgfsolutions Ltd | Information & communication | 2007 |
| DGL Technology Limited | Information & communication | 2004 |
| DGM Heating Ltd | Construction | 2005 |
| Dgms Limited | Manufacturing | 2009 |
| DGP Intelsius Limited | Administrative & support | 1998 |
| DGP Life Science Limited | Professional & scientific | 2001 |
| DH Transport Consultancy Ltd | Transport & logistics | 2017 |
| Dhesi Enterprises Limited | Real estate | 2014 |
| Dhgm Ltd | Health & social care | 2025 |
| DHI Event Horses Ltd | Agriculture & fishing | 2005 |
| DHP Event Production Limited | Arts & recreation | 2021 |
| DHR Property Services Ltd | Construction | 2021 |
| Dhven Limited | Wholesale & retail | 2023 |
| Dialtone Events Ltd | Administrative & support | 2026 |
| Diamond Clean York Ltd | Administrative & support | 2019 |
| Diamond Domestics Ltd | Administrative & support | 2022 |
| Diamond Fadez Ltd | Other services | 2023 |
| Diamond York Limited | Wholesale & retail | 2011 |
| Diamonds Dutch Ltd | Hospitality | 2025 |
| Diamonds for YOU Ltd | Wholesale & retail | 2025 |
| Diamonds Guest House Ltd | Hospitality | 2016 |
| Diamonds Inn Ltd | Hospitality | 2018 |
| Diamonds Lodge Ltd | Hospitality | 2019 |
| Diamonds Property Development Private Ltd | Wholesale & retail | 2020 |
| Diamonds Villa Ltd | Hospitality | 2016 |
| Diaz Interiors Limited | Professional & scientific | 2022 |
| Dick Turpin (York) Limited | Wholesale & retail | 2007 |
| Dickens Heath (Phase II) Management Company Limited | Households | 1998 |
| Dickinson Hadley Ltd | Professional & scientific | 2018 |
| Digi AI Marketing Ltd | Professional & scientific | 2025 |
| Digicog Tech Ltd | Manufacturing | 2025 |
| Digifish Limited | Information & communication | 2007 |
| Diginite Limited | Professional & scientific | 2024 |
| Digital Preservation Coalition | Other services | 2002 |
| Digital Railway Long -Term Planner Limited | Construction | 2021 |
| Digital Savant Ltd | Information & communication | 2014 |
| Digital Spaces Limited | Extraterritorial | 2004 |
| Digital Team Group Limited | Information & communication | 2026 |
| Digital Video Unified Systems Ltd | Information & communication | 2021 |
| Digital White House Limited | Professional & scientific | 2020 |
| Digitally Consulting Ltd | Professional & scientific | 2016 |
| Digitally Crafted Ltd | Information & communication | 2020 |
| Digitalxpansion Ltd | Professional & scientific | 2020 |
| Digitsign Ltd | Information & communication | 2009 |
| Dihao Leeds Ltd | Hospitality | 2026 |