| Daztag Solutions Limited | Information & communication | 2021 |
| Dazzling Dummies Ltd | Wholesale & retail | 2012 |
| DB Agriculture Limited | Wholesale & retail | 2005 |
| DB Joinery Solutions Ltd | Construction | 2023 |
| DB Muckett Limited | Professional & scientific | 2014 |
| DBD Cleaning Limited | Administrative & support | 2015 |
| DBI Exhibitions Ltd | Construction | 2025 |
| DBL Automotive Ltd | Wholesale & retail | 2025 |
| DBM (York) Ltd | Hospitality | 2019 |
| DBN York Ltd. | Construction | 2025 |
| DBP Consulting Ltd. | Professional & scientific | 2017 |
| DBS Service Centre Limited | Manufacturing | 2001 |
| Dbtoledo Ltd | Health & social care | 2024 |
| DC Commercial Consulting Limited | Information & communication | 2026 |
| DC Custom Campers Limited | Wholesale & retail | 2023 |
| DCC Property (York) Ltd | Real estate | 2026 |
| DCD Print Ltd | Extraterritorial | 2019 |
| DCF Solutions Ltd | Other services | 2022 |
| DCL Consultancy Ltd | Professional & scientific | 2024 |
| DCW Consultants Ltd | Professional & scientific | 2019 |
| Ddfilms Limited | Information & communication | 2007 |
| DE Facto Reports Limited | Real estate | 2010 |
| DE Grey Club Ltd | Other services | 2025 |
| DE Jubbergate Ltd | Hospitality | 2023 |
| DE Little Court (York) Management Company Limited | Households | 2001 |
| DE Lucy Place (Ongar) Residents Management Company Limited | Households | 2026 |
| DE Mowbray Court Management Company Limited | Households | 1995 |
| DE Vere Grove (Colchester) Residents Management Company Limited | Households | 2022 |
| DE Vere Securities Ltd | Wholesale & retail | 2006 |
| Dead Reset Ltd | Information & communication | 2024 |
| Deals on Wheels Limited | Extraterritorial | 1991 |
| Dealsrate.Com Ltd | Administrative & support | 2026 |
| Deamadre Ltd | Hospitality | 2024 |
| Dean Construction & Groundworks Limited | Construction | 2011 |
| Dean Landscapes Limited | Administrative & support | 2006 |
| Dean Rose Solutions Limited | Information & communication | 2009 |
| Deans Haddon Limited | Professional & scientific | 2022 |
| Dear Stranger Publication Ltd | Information & communication | 2021 |
| Death in a Chocolate Box Limited | Administrative & support | 2019 |
| Deathly Dark Tours Limited | Arts & recreation | 2024 |
| Deborahp.Holdings Ltd | Hospitality | 2025 |
| Decent Stays Ltd | Real estate | 2022 |
| Decima Consultancy Ltd | Administrative & support | 2018 |
| Decorating DIY Supplies Ltd | Wholesale & retail | 2022 |
| Decumana Limited | Real estate | 2025 |
| Dedicated Computer Consultants Limited | Information & communication | 1998 |
| Deeley Holdings Ltd | Professional & scientific | 2025 |
| Deemlane Limited | Real estate | 1995 |
| Deep Blue Sea (Helmsley) Limited | Hospitality | 2025 |
| Deep Breath Ltd | Manufacturing | 2019 |
| Deep Value Asset Management LLP | | 2024 |
| Deep-Inside Ltd | Health & social care | 2019 |
| Deepblue Direct UK Limited | Information & communication | 2021 |
| Deepex Cleaning Company Ltd | Administrative & support | 2022 |
| Deepjam Limited | Arts & recreation | 2007 |
| Deer Flip Games Ltd | Information & communication | 2020 |
| Deer Park Retail Village Ltd | Construction | 2018 |
| Deerwood Park ( Colne) Management Company Limited | Households | 2016 |
| Defender Parts UK Limited | Wholesale & retail | 2024 |
| Deferonomy Partners Limited | Wholesale & retail | 2007 |
| Defib Central Limited | Wholesale & retail | 2016 |
| Defining IT Ltd | Extraterritorial | 2006 |
| Definition Body Coaching Limited | Arts & recreation | 2017 |
| Deglin Enterprises LP | | 2013 |
| Deighton Electrical Services Ltd | Construction | 2020 |
| Deighton Investments Ltd | Real estate | 2019 |
| Deighton Lets Ltd | Hospitality | 2021 |
| Deighton Limited | Wholesale & retail | 2025 |
| Deighton Lodge Limited | Hospitality | 2013 |
| Deighton Plumbing Ltd | Real estate | 2018 |
| Deighton Plumbing York Ltd | Construction | 2025 |
| Deira Marketing Limited | Wholesale & retail | 2010 |
| Deirdre Brown Travel Ltd | Financial services | 2017 |
| Deko Design Ltd | Manufacturing | 2020 |
| DEL Grosso Family Holdings Limited | Financial services | 2025 |
| Delany Brothers (House Builders) Limited | Extraterritorial | 1977 |
| Delfino Caffe Bars Ltd | Hospitality | 2017 |
| Delgeo LLP | | 2016 |
| Delibero Limited | Professional & scientific | 2017 |
| Delight Pizza 2 Ltd | Hospitality | 2025 |
| Dell Holdings York Ltd | Hospitality | 2025 |
| Delma Tomlin Arts Management Limited | Professional & scientific | 2008 |
| Delta Healthcare and Cosmetics Clinic Limited | Health & social care | 2016 |
| Delta Healthcare and Cosmetics Limited | Health & social care | 2020 |
| Delta Silanus Ltd | Hospitality | 2022 |
| Delta Wagyu Europe Limited | Agriculture & fishing | 2016 |
| Dely Delivery Ltd | Transport & logistics | 2020 |
| Demeures Traditionnelles DU Rhone Ltd | Construction | 2023 |
| Demir Dogan Ltd | Other services | 2019 |
| Denbond Holdings Limited | Health & social care | 2017 |
| Dencold Cooling Solutions Ltd | Construction | 2026 |
| Denis York Ltd | Hospitality | 2022 |
| Denison Ltd | Manufacturing | 2003 |
| Dennings Yard (York) Limited | Construction | 2024 |
| Dennis King Electrical Limited | Construction | 2007 |
| Denny Investments | Financial services | 2013 |
| Denshaw Developments Limited | Real estate | 1998 |
| Dent Master York Ltd | Wholesale & retail | 2024 |
| Dentcal Limited | Health & social care | 2024 |
| Dentistry North East Limited | Health & social care | 2026 |