| Stirling Ventures Limited | Construction | 2006 |
| Stitch.Ldn Limited | Wholesale & retail | 2022 |
| Stittenham Developments Limited | Construction | 2019 |
| STLX6 Ltd | Real estate | 2018 |
| Stobo Health Limited | Health & social care | 2014 |
| Stock Control U.K. Ltd. | Hospitality | 2004 |
| STOCK1ST Limited | Extraterritorial | 2002 |
| Stockco Limited | Wholesale & retail | 2020 |
| Stockport Stone Limited | Real estate | 2016 |
| Stocksmore Limited | Administrative & support | 2013 |
| Stokes Masonry & Stone Limited | Construction | 2015 |
| Stokes Renewable Solutions Ltd | Construction | 2024 |
| Stol Aviation Ltd | Wholesale & retail | 2021 |
| Stone Connection Group Ltd | Financial services | 2015 |
| Stone Connection Holdings Ltd | Financial services | 2024 |
| Stone Connection Worksurfaces Ltd | Manufacturing | 2012 |
| Stone Court (Dalton Terrace) Management Limited | Real estate | 2009 |
| Stone Roses Bar (York) Ltd | Hospitality | 2011 |
| Stone Run Limited | Financial services | 2015 |
| Stonecloud Limited | Arts & recreation | 2011 |
| Stonefield Developments (Yorkshire) Limited | Real estate | 2006 |
| Stoneforth Limited | Real estate | 2008 |
| Stonegate 1434 | Real estate | 1965 |
| Stonegate Dental Studio Limited | Health & social care | 2023 |
| Stonegate Health Consultancy Ltd | Professional & scientific | 2023 |
| Stonegate Investments Ltd | Real estate | 2017 |
| Stonegate Paving and Groundworks Ltd | Construction | 2026 |
| Stonegate Teddy Bears Ltd | Wholesale & retail | 2022 |
| Stonegrave Construction Limited | Construction | 2002 |
| Stonegrave Properties Limited | Real estate | 2001 |
| Stonehill Surveyors Ltd | Professional & scientific | 2020 |
| Stonehouse Fireplaces Ltd | Wholesale & retail | 2025 |
| Stoneplan Limited | Administrative & support | 2003 |
| Stonerose Limited | Extraterritorial | 1996 |
| Stoneroyd Properties Limited | Real estate | 2003 |
| Stoney Springs Mill Management Limited | Households | 2008 |
| Storage HUT Ltd | Real estate | 2020 |
| Storey House Developments Limited | Construction | 2025 |
| Storey House Ltd | Real estate | 2022 |
| Stormsec Cyber Security Limited | Information & communication | 2021 |
| Stortford Fields (Bishops Stortford) (Persimmon) Resident Management Company Limited | Households | 2018 |
| Storwood Farming Limited | Agriculture & fishing | 2008 |
| Storwood Game Limited | Agriculture & fishing | 2007 |
| Story Captain Limited | Information & communication | 2022 |
| Story Craft Theatre Limited | Arts & recreation | 2018 |
| Storyfound Ltd | Information & communication | 2023 |
| Stosh Limited | Manufacturing | 2018 |
| Stoshspace Limited | Administrative & support | 2018 |
| Stout Accountancy Limited | Professional & scientific | 2014 |
| Stovokor Ltd | Real estate | 2025 |
| Stox Karts Ltd | Arts & recreation | 2009 |
| Stoyam Holdings Limited | Professional & scientific | 1971 |
| Stphnsn Ltd | Information & communication | 2018 |
| Straight Down the Middle Communications Limited | Information & communication | 2012 |
| Strata North Limited | Construction | 2026 |
| Strategic Developments (Yorkshire) Ltd | Real estate | 2021 |
| Strategic Land Regeneration Services Limited | Real estate | 2011 |
| Strategic Tourism Limited | Professional & scientific | 2003 |
| STRATEGY360 Limited | Professional & scientific | 2024 |
| Strathheaven Limited | Administrative & support | 2011 |
| Stratic Consulting Ltd. | Information & communication | 2017 |
| Stratim Limited | Professional & scientific | 2023 |
| Strawberry Fields Penryn Management Company Limited | Households | 2011 |
| Straza Group Ltd | Financial services | 2026 |
| Straza Ltd | Administrative & support | 2025 |
| Streamline Taxis (York) Limited | Other services | 1990 |
| Streather Consultancy Ltd | Professional & scientific | 2017 |
| Streekz Hair Company Limited | Other services | 2007 |
| Street Soldier Ltd | Arts & recreation | 2022 |
| Strensall Community, Youth and Sports Association | Arts & recreation | 2011 |
| Strensall Property Services Ltd | Manufacturing | 2015 |
| Strickland Beech Limited | Professional & scientific | 2022 |
| Strickland Films Ltd | Information & communication | 2022 |
| Stride AI Ltd | Information & communication | 2026 |
| Striding Edge Construction Ltd | Construction | 2024 |
| Stroud Resourcing Limited | Administrative & support | 2008 |
| Structr Ltd | Information & communication | 2026 |
| Strut Building Surveyors Limited | Professional & scientific | 2025 |
| Stuart and Associates Ltd | Professional & scientific | 2015 |
| Stuart Beales Consultancy Ltd | Professional & scientific | 2023 |
| Stuart Construction Ltd | Construction | 2021 |
| Stuart Garrington Limited | Education | 2018 |
| Stuart Lawton Limited | Other services | 2001 |
| Stuart Property Development Ltd | Construction | 2024 |
| Stucco & Stucco Harrogate Ltd | Construction | 2025 |
| Student Accommodation Provision Three LLP | | 2013 |
| Student Landlord Services LLP | | 2013 |
| Studford Agtech Ltd | Information & communication | 2020 |
| Studford Luxury Lodges Limited | Real estate | 2011 |
| Studio 147 Ltd | Wholesale & retail | 2022 |
| Studio 35 (York) Limited | Wholesale & retail | 2016 |
| Studio Akeelah Bertram Ltd | Arts & recreation | 2020 |
| Studio Braak Limited | Real estate | 2023 |
| Studio Cloud Nine Ltd | Arts & recreation | 2018 |
| Studio Dekka Limited | Professional & scientific | 2009 |
| Studio IKA Ltd | Information & communication | 2022 |
| Studio Lowe Ltd | Information & communication | 2021 |
| Studio Simon Ltd | Professional & scientific | 2019 |
| Studio Skye Ltd | Other services | 2022 |
| STUDIO573 Ltd | Manufacturing | 2025 |