| Studioleeroy Limited | Professional & scientific | 2019 |
| Studiostack Ltd | Information & communication | 2025 |
| Study Haven Ltd | Real estate | 2025 |
| Stuff at the Mill Ltd | Hospitality | 2021 |
| Stuff My Spud Ltd | Wholesale & retail | 2025 |
| Stugdale Limited | Administrative & support | 2003 |
| Stump Removal Yorkshire Limited | Agriculture & fishing | 2015 |
| Sturley Mortgages Limited | Financial services | 2006 |
| Styfcsd Ltd | Wholesale & retail | 2025 |
| Style & Serve Ltd | Wholesale & retail | 2025 |
| Style Flooring of York Limited | Wholesale & retail | 2015 |
| Styledinbela Ltd | Wholesale & retail | 2024 |
| SUB International Ltd | Wholesale & retail | 2017 |
| Subheat Limited | Construction | 2012 |
| Subleq Ltd | Information & communication | 2025 |
| Subsea and Marine Consultancy Services Limited | Professional & scientific | 2011 |
| Subsea Projects (UK) Limited | Professional & scientific | 2008 |
| Subsea Tooling Operations Limited | Administrative & support | 2017 |
| Success Methods Limited | Information & communication | 2018 |
| Successful Futures Ltd | Education | 2017 |
| Sufiix Ltd | Wholesale & retail | 2019 |
| Sugarize Ltd | Wholesale & retail | 2017 |
| Sugarstar Limited | Information & communication | 2001 |
| Suggitt Electrical Limited | Construction | 2015 |
| Suhail Company Limited | Agriculture & fishing | 2020 |
| Suite Natured Ltd | Arts & recreation | 2021 |
| Suki Convenience Ltd | Wholesale & retail | 2018 |
| Sulla Transport Ltd | Transport & logistics | 2017 |
| Sullivan Bloodstock Limited | Arts & recreation | 2014 |
| Sullivan Group Limited | Professional & scientific | 2015 |
| Sullivan Homes Limited | Construction | 1997 |
| Sullivan Student Properties Limited | Real estate | 2011 |
| Sumec UK Co. Ltd | Wholesale & retail | 2011 |
| Summer Belles Ltd | Administrative & support | 2022 |
| Summer Clinical Limited | Health & social care | 2023 |
| Summer Rose Apartment Limited | Households | 2020 |
| Summer Rose Commercial Ltd | Real estate | 2021 |
| Summer Rose Developments Ltd | Real estate | 2021 |
| Summer Rose Properties Ltd | Hospitality | 2020 |
| Summer Ventures Limited | Construction | 2020 |
| Summerhouse Mews Management Company Limited | Households | 2011 |
| Summerleaze Pet Crematorium Limited | Extraterritorial | 2005 |
| Summers Consulting Limited | Professional & scientific | 2022 |
| Summers Day Ltd | Professional & scientific | 2021 |
| Summitview Apps Ltd | Information & communication | 2026 |
| Sumo UK Ltd. | Manufacturing | 1996 |
| Sun and Sons Limited | Financial services | 2025 |
| Sun Electrical (York) Ltd | Energy | 2011 |
| Sun Properties (York) Limited | Real estate | 2024 |
| Sundar Consulting Ltd | Administrative & support | 2020 |
| Sunde Holding Limited | Administrative & support | 2024 |
| Sunflowers Day Nurseries (East Yorkshire) Limited | Education | 2007 |
| Sunkissed Acomb Ltd | Other services | 2021 |
| Sunny Soap Ltd | Manufacturing | 2023 |
| Sunny’S Catering Limited | Hospitality | 2019 |
| Sunrise Grips Limited | Information & communication | 2025 |
| Sunrise Properties WV1 Ltd | Real estate | 2011 |
| Sunshine Day Nursery (York) Ltd | Health & social care | 2004 |
| Sunshine Oriental Supermarket Ltd | Wholesale & retail | 2018 |
| Sunshine Properties York Ltd | Real estate | 2025 |
| Sunstrider Ltd | Wholesale & retail | 2024 |
| Suntrust Limited | Financial services | 1979 |
| SUP SOL Beverley Ltd | Health & social care | 2022 |
| Super Assembly Ltd | Financial services | 2025 |
| Super Bytes Limited | Information & communication | 2023 |
| Super Clean Windows Ltd. | Administrative & support | 2020 |
| Super Radical Ltd | Professional & scientific | 2013 |
| Superb Smart Homes Ltd | Construction | 2022 |
| Supercrush Piling Limited | Extraterritorial | 2015 |
| Superlife Industries Limited | Information & communication | 2017 |
| Superlinear Design Limited | Information & communication | 2022 |
| Superprop Ltd | Manufacturing | 2014 |
| Supplements Wise Ltd | Wholesale & retail | 2015 |
| Supply Sales Ltd | Professional & scientific | 2019 |
| Support Chef Ltd | Hospitality | 2023 |
| Support Holdings Ltd | Real estate | 2023 |
| Support Solutions Franchise Ltd | Professional & scientific | 2020 |
| Supported Recruitment Ltd | Administrative & support | 2017 |
| Supportive Counselling Ltd | Health & social care | 2026 |
| Supsol Harrogate Ltd | Health & social care | 2021 |
| Sural Enterprises Limited | Construction | 1984 |
| Sure Solar Ltd | Manufacturing | 2019 |
| Sure Thing Developments Limited | Construction | 2005 |
| Surveyitnow Ltd | Information & communication | 2013 |
| Surveyors UK (Advantage) Ltd | Information & communication | 2020 |
| Surveys & Defect Reports Ltd | Professional & scientific | 2013 |
| Survive (Support for Survivors of Rape and Sexual Abuse) | Health & social care | 1997 |
| Susan E Bradbury Ltd | Health & social care | 2010 |
| Sustainable Food Chains Ltd | Professional & scientific | 2013 |
| Sustainable Hospitality Limited | Hospitality | 2025 |
| Sustainable Safety Group Limited | Administrative & support | 2009 |
| Sustainably Built Limited | Administrative & support | 2008 |
| Sutherland Properties (York) Limited | Real estate | 2024 |
| Sutherland Property Ventures Ltd | Real estate | 2024 |
| Suttle Transport Services Ltd | Transport & logistics | 2013 |
| Sutton Park Residents Management Co. Limited | Households | 1998 |
| Sutton Property Partners Ltd | Real estate | 2025 |
| Sutton Village Gymnastics Limited | Arts & recreation | 2019 |
| SVG Properties LLP | | 2012 |
| SVG Property Investments Ltd | Financial services | 2018 |