| Standoutbranding Ltd | Manufacturing | 2024 |
| Stanford Meadows (Stanford-Le-Hope) Residents Management Company Limited | Households | 2020 |
| Stanfordrhodes Wealth Management Limited | Financial services | 2005 |
| Stanfordrhodes Wealth Protection Ltd | Financial services | 2016 |
| Stanhope Gardens Management Limited | Households | 2024 |
| Stanley & Ramona Limited | Hospitality | 2017 |
| Stanton Chase (Swindon) Management Company Limited | Households | 2023 |
| Stanton Locations Ltd | Information & communication | 2024 |
| Stapleton Waterhouse Ltd | Real estate | 2003 |
| Star & Keys Properties Ltd | Real estate | 2023 |
| Star Care Consultancy Limited | Administrative & support | 2024 |
| Star Fast Food Ltd | Hospitality | 2024 |
| Star Salon Limited | Other services | 2025 |
| Star Street (York) LLP | | 2020 |
| Star Street Escapes Ltd | Other services | 2024 |
| Starbrite Studios Ltd | Education | 2013 |
| Starcompliance Operating, LLC | | 2005 |
| Starfitts Farms Limited | Agriculture & fishing | 2018 |
| Stargrange IT Limited | Information & communication | 2007 |
| Starkey Financial Consulting Ltd | Professional & scientific | 2019 |
| Starr Financial Limited | Financial services | 2008 |
| Start SEO Ltd | Professional & scientific | 2022 |
| Start Trading Limited | Arts & recreation | 1995 |
| Startherm Ltd | Professional & scientific | 2018 |
| Startlabs Ltd | Information & communication | 2019 |
| Startlabs Media Limited | Information & communication | 2020 |
| Startone Limited | Financial services | 2006 |
| Starwise Import Export Limited | Households | 2015 |
| Station House Day Nursery Limited | Education | 2017 |
| Station Road (Sturton) Developments Ltd | Construction | 2022 |
| Stationary Engine Parts Ltd | Wholesale & retail | 2006 |
| Statphill Industries Ltd | Hospitality | 2018 |
| Status 218 Limited | Professional & scientific | 2023 |
| Stay Compliant Limited | Professional & scientific | 2017 |
| Staycation York Limited | Real estate | 2015 |
| Staycays UK Ltd | Real estate | 2020 |
| Staygram Ltd | Professional & scientific | 2024 |
| Staynor Hall 4 (Selby) Residents Management Company Limited | Real estate | 2022 |
| Staynor Hall K (Selby) Management Company Limited | Real estate | 2021 |
| Stays by R&W Ltd | Real estate | 2025 |
| Stays York Limited | Hospitality | 2022 |
| Stead Investment (Holdings) Ltd | Construction | 2024 |
| Steady Solutions Ltd | Professional & scientific | 2023 |
| Steel Horse Garage Ltd | Wholesale & retail | 2020 |
| Steel Horse Motorcycles Ltd | Wholesale & retail | 2020 |
| Steelhaven (7) Limited | Extraterritorial | 1980 |
| Steelmoor Engineering Limited | Professional & scientific | 2018 |
| Steer and Co. Financial Planning Limited | Administrative & support | 2026 |
| Steered Success Limited | Administrative & support | 2019 |
| Stefern Fashion Accessories Ltd | Wholesale & retail | 2019 |
| Stellify Limited | Information & communication | 2013 |
| Stelmart Ltd | Wholesale & retail | 2024 |
| Stem Learning Limited | Education | 2004 |
| Stemount Investments Limited | Real estate | 2014 |
| Stenby Limited | Construction | 2023 |
| Stenness Limited | Professional & scientific | 2013 |
| Step-Easy Chiropractic Limited | Health & social care | 2008 |
| Stephen Mitchell Consulting Limited | Professional & scientific | 2017 |
| Stephen Sherlock Services Limited | Other services | 2017 |
| Stephenson & SON Agricultural LLP | | 2019 |
| Stephenson Jones Ltd | Administrative & support | 2007 |
| Stephenson Park (Wallsend) Residents Management Company Limited | Real estate | 2021 |
| Stephenson Plumbing Services Ltd | Construction | 2019 |
| Stephenson Properties (York) Limited | Real estate | 2018 |
| Stephenson's Court (Management Company) Limited | Households | 2006 |
| Stephenson's Development Limited | Construction | 2026 |
| Stephenson's Gallery Limited | Arts & recreation | 2024 |
| Stephensons Estate Agents LLP | | 2016 |
| Stephensons Rural LLP | | 2019 |
| Stereo Hoare Ltd | Wholesale & retail | 2025 |
| Sterling Ascent Limited | Financial services | 2022 |
| Sterling Build (Yorkshire) Ltd | Construction | 2023 |
| Sterling Life and Mortgages Limited | Extraterritorial | 2010 |
| Sterling Routines Limited | Administrative & support | 2026 |
| Sterling Tide LLP | | 2024 |
| Steve Blissett Joinery & Building Services Limited | Construction | 2019 |
| Steve Charlton Building & Joinery Limited | Construction | 2009 |
| Steve Cook Training Ltd | Other services | 2005 |
| Steve French Joinery Ltd | Construction | 2016 |
| Steve James Environmental Health Services Ltd | Professional & scientific | 2012 |
| Steve Lockwood Joinery Limited | Construction | 2005 |
| Steve Miller Flooring Services Limited | Construction | 2002 |
| Steve Rudd Associates Limited | Financial services | 2022 |
| Steve Twynham Limited | Other services | 2008 |
| Steve Wilcock Plumbing & Heating Engineers Ltd | Manufacturing | 2011 |
| Steve Wood Services Limited | Administrative & support | 2003 |
| Steven Carlton Kitchen Fitters Limited | Construction | 2007 |
| Steven Mcdonald Consulting Ltd | Professional & scientific | 2021 |
| Steven Sharpley Commercials Ltd | Wholesale & retail | 2009 |
| Steven Walsh Joinery Ltd | Manufacturing | 2023 |
| Stevens-Kelly Consulting Ltd | Administrative & support | 2025 |
| Stevenson CPL Services Ltd | Construction | 2013 |
| Stewards House Ltd | Hospitality | 2025 |
| Stewart Forbes Electrical Services Ltd | Construction | 2020 |
| Stewart Properties and Lettings Limited | Construction | 2013 |
| Stewpot Management Limited | Real estate | 2003 |
| STG (York) Limited | Wholesale & retail | 2023 |
| Sticky Fingers Tiny School Limited | Education | 2007 |
| Stirk House Logistics Ltd | Wholesale & retail | 2019 |
| Stirling Resolution Ltd | Professional & scientific | 2025 |