| SAM 22 Limited | Hospitality | 2025 |
| SAM and Jays Ltd | Hospitality | 2020 |
| SAM Cockerill Limited | Professional & scientific | 2008 |
| SAM Express (2025) Limited | Wholesale & retail | 2025 |
| SAM Olgar Hair Limited | Households | 2017 |
| SAM Olgar Hairdressers Salon Ltd | Households | 2024 |
| SAM Pearce Limited | Manufacturing | 2026 |
| SAM Pooley Ltd | Construction | 2025 |
| Samantha Gardner Title Checking Limited | Professional & scientific | 2022 |
| Sambarca Futsal Limited | Education | 2018 |
| Samford Gardens (Capel ST Mary) Residents Management Company Limited | Households | 2021 |
| Sammie's Van Ltd | Hospitality | 2022 |
| Sammonsbaileys Ltd | Hospitality | 2026 |
| Sams PVT Ltd | Real estate | 2026 |
| Samson Fitness Ltd | Arts & recreation | 2020 |
| Samson Interiors Limited | Construction | 2018 |
| Samuel Austin Ltd | Arts & recreation | 2022 |
| Samuel Odiwe Limited | Professional & scientific | 2026 |
| SAN Foods Limited | Hospitality | 2023 |
| SAN Sebastian Cheesecake Ltd | Manufacturing | 2025 |
| Sana Dent Ltd | Health & social care | 2021 |
| Sanahar Ltd | Wholesale & retail | 2022 |
| Sanchuri Design Limited | Professional & scientific | 2006 |
| Sanctuary Property Group Ltd | Hospitality | 2005 |
| Sanctuary Vets Ltd | Extraterritorial | 2012 |
| Sanctus Academy Amateur Boxing Club CIC | Arts & recreation | 2023 |
| Sandburn York Limited | Hospitality | 1983 |
| Sanders Landscape Services Ltd | Administrative & support | 2014 |
| Sanderson Brown Ltd | Professional & scientific | 2021 |
| Sanderson Heating & Renewables Limited | Construction | 2024 |
| Sandfield Walk (Nottingham) Management Company Limited | Households | 2018 |
| Sandgate Drive (Kippax) Management Company Limited | Households | 2017 |
| Sandham Estates LLP | | 2021 |
| Sandhills Alpaca Pods Ltd | Construction | 2020 |
| Sandholme Country Park Limited | Wholesale & retail | 2017 |
| Sandiron House RTM Company Limited | Households | 2024 |
| Sandringham Court (York) Freehold Management Company Limited | Households | 2022 |
| Sandy Investments Limited | Real estate | 2006 |
| Sandybay Lodges Ltd | Hospitality | 2021 |
| Sandylane Limited | Health & social care | 2000 |
| Sandyridge Limited | Real estate | 2019 |
| Sane Design Limited | Manufacturing | 2011 |
| Sangers and Mash Limited | Professional & scientific | 2009 |
| Sangthai Restaurant (2022) Ltd | Hospitality | 2022 |
| Sangthai Restaurant Limited | Real estate | 1999 |
| Sangwin Investments Ltd | Real estate | 2026 |
| Saniana Developments Limited | Professional & scientific | 2024 |
| Sans-Jassar Holdings Ltd | Real estate | 2009 |
| Sansome Homes Ltd | Real estate | 2022 |
| Santa Yanla Limited | Health & social care | 2019 |
| Sapphire Equestrian Limited | Agriculture & fishing | 2014 |
| Sapphire Imaging Limited | Extraterritorial | 2010 |
| Sapphire Tradelinks Ltd | Wholesale & retail | 2023 |
| SAR Contracting Ltd | Health & social care | 2023 |
| Sara Parrott Equestrian Ltd | Agriculture & fishing | 2015 |
| Sarell Ltd | Information & communication | 2024 |
| Sargable Group Ltd | Information & communication | 2016 |
| Sarir Holdings Ltd | Professional & scientific | 2014 |
| Sark Industries Limited | Real estate | 2023 |
| Sarl A.S.C. Invest Ltd | Financial services | 2021 |
| Sarl M2 Invest Ltd | Financial services | 2023 |
| Sarl Sala Ltd | Financial services | 2022 |
| Sarmka Limited | Wholesale & retail | 2017 |
| Sarthe Limited | Real estate | 2011 |
| SAS BF Ltd | Financial services | 2023 |
| SAS Fabrications (York) Ltd | Manufacturing | 2016 |
| SAS JPF Groupe Ltd | Financial services | 2022 |
| SAS Silver Cottage Ltd | Construction | 2023 |
| Sashay Dance Limited | Arts & recreation | 2023 |
| Saskia and Rose Limited | Wholesale & retail | 2016 |
| Sassafrass Music UK Ltd | Arts & recreation | 2025 |
| Sassy & Chic Limited | Wholesale & retail | 2017 |
| Sasti Retails UK Ltd | Wholesale & retail | 2016 |
| Sasu BET Ceteba Ltd | Construction | 2020 |
| Sati Jardin Limited | Health & social care | 2023 |
| Saunders Henderson Limited | Manufacturing | 2024 |
| Sausage Properties Ltd | Real estate | 2020 |
| Save and Prosper Ltd | Professional & scientific | 2014 |
| Saville Audio Visual Limited | Manufacturing | 2014 |
| Saving Faces Limited | Health & social care | 2006 |
| Savix Limited | Professional & scientific | 2017 |
| Savna Limited | Wholesale & retail | 2023 |
| Savoy Court (Scarborough) Freehold Limited | Households | 2025 |
| Saxbridge Limited | Real estate | 2014 |
| Saxena Property Holdings Ltd | Real estate | 2022 |
| Saxon Feld Properties Limited | Real estate | 2000 |
| Saxon Fields (Bridgwater) Management Company Limited | Real estate | 2019 |
| Saxon Grange (Shaftesbury) Management Company Limited | Households | 2022 |
| Saxon Grange Phase 2 (Shaftesbury) Residents Management Company Limited | Households | 2025 |
| Saxon Grove (Purton) Management Company Limited | Households | 2020 |
| Saxon Meadow (Sutton on Trent) Residents Management Company Limited | Households | 2019 |
| Saxons Chase (Headcorn) Residents Management Company Limited | Households | 2019 |
| SAY YES Commerce Ltd | Professional & scientific | 2024 |
| Sayles Electrical Services Ltd | Manufacturing | 2022 |
| SB 1066 Ltd | Hospitality | 2026 |
| SB Beauty Limited | Other services | 2010 |
| SB Learning and Development Limited | Professional & scientific | 2016 |
| SB Manufacturing Improvement Ltd | Professional & scientific | 2022 |
| Sbash PVT Limited | Wholesale & retail | 2024 |
| SBF Joinery Ltd | Construction | 2024 |