| SBK Real Estate Limited | Real estate | 2025 |
| SBK Surveys Ltd | Professional & scientific | 2011 |
| SBL York Ltd | Hospitality | 2024 |
| SBO Lands Limited | Hospitality | 2014 |
| Sbrx Limited | Arts & recreation | 2023 |
| SBS (York) Limited | Professional & scientific | 2006 |
| Sbsmile Limited | Health & social care | 2021 |
| SBW Property Holdings Ltd | Real estate | 2026 |
| SC (Harrogate) Management Company Limited | Households | 2018 |
| SC Finance Limited | Financial services | 2018 |
| Scale Drinks Export Limited | Professional & scientific | 2023 |
| Scalp Zero Ltd | Wholesale & retail | 2026 |
| SCAN4HEALTH Solutions Ltd | Information & communication | 2017 |
| Scarborough and Ryedale Care Limited | Health & social care | 2019 |
| Scarcroft Ltd | Information & communication | 2019 |
| Scarlet View Media Limited | Information & communication | 2012 |
| Scarlett Mews (Tiptree) Residents Management Company Limited | Households | 2023 |
| Scarlett's Stays Ltd | Real estate | 2026 |
| Scarlettabbott (Topco) Limited | Financial services | 2022 |
| Scarlettabbott Ltd | Professional & scientific | 2004 |
| SCB Financial Services Limited | Financial services | 1996 |
| Scented Scenes Candle Company Ltd | Extraterritorial | 2021 |
| Scented Yorkshire Ltd | Wholesale & retail | 2023 |
| SCG MH Services Limited | Administrative & support | 2015 |
| Schiewe Ceramics Limited | Arts & recreation | 2023 |
| Schoen Clinic London Ltd | Health & social care | 2016 |
| Schoen Clinic UK Ltd | Administrative & support | 2017 |
| Schofield Plumbing Services Ltd | Manufacturing | 2006 |
| Schofields EQS Limited | Professional & scientific | 2012 |
| Scholars Gate (Hull) Management Company Limited | Households | 2014 |
| School Tools Limited | Information & communication | 2016 |
| SCI Aveline Ltd | Real estate | 2022 |
| Science and Testing Group Limited | Financial services | 2025 |
| Science City York Limited | Professional & scientific | 2007 |
| Scientists for EU Limited | Health & social care | 2015 |
| Scima Limited | Information & communication | 2013 |
| Scimitars Consultancy Limited | Professional & scientific | 2025 |
| SCM Limited | Health & social care | 2025 |
| Scmc (York) Ltd | Real estate | 2012 |
| Scooby Bidco Limited | Financial services | 2018 |
| Scorpus Holdings Limited | Wholesale & retail | 2021 |
| Scotchbrook Invest Ltd | Real estate | 2026 |
| Scotfire Safety Solutions Ltd | Public administration | 2010 |
| Scotsman Methodology Limited | Administrative & support | 2025 |
| Scott & Co. Limited | Agriculture & fishing | 2010 |
| Scott Tech and Mobile Ltd | Wholesale & retail | 2025 |
| Scott-Lock Ltd | Manufacturing | 2017 |
| Scotton Park Limited | Manufacturing | 2006 |
| Scotts Pasture Limited | Professional & scientific | 2024 |
| SCP Projects Limited | Professional & scientific | 2016 |
| Scratchmypi Ltd | Education | 2013 |
| Scuba York Ltd | Education | 2023 |
| Sculparc Ltd | Other services | 2017 |
| SCW Healthcare Ltd | Health & social care | 2020 |
| SCY Enterprise Ltd | Extraterritorial | 2010 |
| SD Building and Joinery Ltd | Construction | 2013 |
| SD Metcalfe Limited | Agriculture & fishing | 2015 |
| SD Motorsport Ltd | Wholesale & retail | 2009 |
| SDG Consultancy Services Limited | Professional & scientific | 2019 |
| SDG Estates (York) LLP | | 2023 |
| SDG Estates Ltd | Real estate | 2024 |
| SDM Services Ltd | Professional & scientific | 2009 |
| Sdsf Supplies Ltd | Wholesale & retail | 2024 |
| SE15 Management Ltd | Real estate | 2026 |
| Sea Haven Psychotherapy Limited | Health & social care | 2023 |
| Seagrove (DC) Ltd | Administrative & support | 2016 |
| Sealance Pro Limited | Professional & scientific | 2016 |
| Sealstop Limited | Manufacturing | 2023 |
| Seamer Road (2011) Limited | Construction | 2011 |
| Seamless Fire Solutions Ltd | Professional & scientific | 2016 |
| Seamless Software Limited | Information & communication | 2016 |
| Sean Ellis Ltd | Professional & scientific | 2024 |
| Sean Hutchinson Ltd | Wholesale & retail | 2013 |
| Seascope Engineering Ltd | Administrative & support | 2024 |
| Seaside Lane (Easington) Management Company Limited | Households | 2015 |
| Season 28 Ltd | Wholesale & retail | 2026 |
| Seaton Vale (Ashington) Residents Management Company Limited | Real estate | 2022 |
| Seaworthy Partners Ltd | Financial services | 2019 |
| Sebby's (Yorkshire) Limited | Hospitality | 2024 |
| SEC1GUARDING Ltd | Administrative & support | 2023 |
| Secerna LLP | | 2011 |
| Secker Taylor Associates Limited | Professional & scientific | 2018 |
| Second City Homes Limited | Extraterritorial | 1972 |
| Second Star to the Right Ltd | Administrative & support | 2023 |
| Second Stitch Ltd | Wholesale & retail | 2023 |
| Secondhand Websites Ltd | Information & communication | 2014 |
| Secret PIE Limited | Wholesale & retail | 2013 |
| Secret Square Ltd | Hospitality | 2019 |
| Secrets of Print Consultancy Ltd | Manufacturing | 2022 |
| Secura Property Ltd | Real estate | 2020 |
| Secure Couriers Ltd | Transport & logistics | 2025 |
| Secureflowai Ltd | Information & communication | 2025 |
| Securicare International Limited | Professional & scientific | 1999 |
| Seddie Ltd | Real estate | 2018 |
| Sediwys Ltd | Professional & scientific | 2026 |
| SEE Change Group Ltd | Professional & scientific | 2016 |
| SEE Green Media Limited | Information & communication | 2008 |
| SEE Green Systems Ltd | Information & communication | 2016 |
| Seebrooks Education & Training Ltd | Administrative & support | 2012 |
| Seedat Legal Consultants Limited | Professional & scientific | 2011 |