| S & V Properties Limited | Real estate | 2013 |
| S a J Mechanical Services Ltd | Manufacturing | 2018 |
| S a Properties (York) Limited | Real estate | 2017 |
| S a Roberts Ltd | Real estate | 2016 |
| S and J Anderson Investments Ltd | Real estate | 2020 |
| S and L Commercial Cleaning Services Ltd | Administrative & support | 2021 |
| S and S Easingwold Limited | Wholesale & retail | 2018 |
| S and W Pizza Ltd | Hospitality | 2024 |
| S B & a Clark (York) Limited | Professional & scientific | 2010 |
| S B & a Clark Farming Limited | Agriculture & fishing | 2010 |
| S B Consultancy York Ltd | Professional & scientific | 2022 |
| S Best Trading Limited | Hospitality | 2022 |
| S Cheetham Construction Ltd | Construction | 2025 |
| S D B Sheet Metal Engineers Limited | Manufacturing | 2006 |
| S D Properties (York) Ltd | Real estate | 2025 |
| S H Advisory Limited | Professional & scientific | 2015 |
| S H R Advisory Ltd | Administrative & support | 2023 |
| S Harrison Construction (York) Ltd | Construction | 2015 |
| S Harrison Developments Manchester Limited | Construction | 2019 |
| S J Danby Ltd | Manufacturing | 1997 |
| S J Danby Properties Ltd | Real estate | 2021 |
| S J LEE Legal Services Limited | Professional & scientific | 2015 |
| S J Page Consultancy Limited | Professional & scientific | 2009 |
| S J Perry Ltd | Professional & scientific | 2012 |
| S J Robinson Properties Limited | Construction | 2018 |
| S Martin Services Ltd | Construction | 2025 |
| S Reid Consulting Limited | Professional & scientific | 2024 |
| S Room & Daughters Transport Limited | Transport & logistics | 2024 |
| S T Bespoke Flooring Ltd | Other services | 2025 |
| S V Armstrong Limited | Professional & scientific | 2010 |
| S Waind & Sons Ltd | Wholesale & retail | 2003 |
| S Webster Joinery Ltd | Manufacturing | 2024 |
| S&D Mcrae Services Limited | Financial services | 2009 |
| S&I Pet and Equestrian Ltd | Wholesale & retail | 2026 |
| S&J Dandy Investments Ltd | Real estate | 2020 |
| S&L Carpets and Laundry Services Ltd | Administrative & support | 2025 |
| S&M Specialist Joiners Limited | Manufacturing | 2005 |
| S.A.F.E Scaffolding (Yorkshire) Ltd | Construction | 2021 |
| S.E.R.M. Ltd | Professional & scientific | 2020 |
| S.Express Inc Ltd | Hospitality | 2024 |
| S.J & F.E Ackerley Limited | Agriculture & fishing | 2010 |
| S.P. Stephenson Limited | Agriculture & fishing | 1982 |
| S.W.H. Building Services Limited | Construction | 2003 |
| S.W.I.F.T. (U.K.) Limited | Professional & scientific | 1976 |
| S2T Limited | Professional & scientific | 2024 |
| SA Returns Limited | Professional & scientific | 1998 |
| Saas Global EOT Limited | Financial services | 2025 |
| Saas Global Limited | Professional & scientific | 2015 |
| Sabo Ltd | Transport & logistics | 2020 |
| Sabs Limited | Professional & scientific | 1998 |
| Saddle Point Science Ltd | Information & communication | 2016 |
| Sadie Alana Pubs Ltd | Hospitality | 2024 |
| Sadlemoor Properties Limited | Construction | 2015 |
| Saero Collective Limited | Professional & scientific | 2023 |
| SAF Medics Ltd | Health & social care | 2023 |
| Safe Creations Landscapes Ltd | Other services | 2024 |
| Safe Fire Consultancy Ltd | Wholesale & retail | 2014 |
| Safe Heights Scaffolding (York) Ltd | Construction | 2024 |
| Safe Service Property Management Ltd | Real estate | 2019 |
| Safe Smiles Ltd | Health & social care | 2026 |
| Safe Student Lets Limited | Real estate | 2024 |
| Safe Student Lets Limited LLP | | 2022 |
| Safe Track Risk Management Ltd | Professional & scientific | 2023 |
| Safe Trust Care Agency Limited | Administrative & support | 2026 |
| Safehomes Developments Ltd | Construction | 2024 |
| Safer Pet Limited | Professional & scientific | 2018 |
| Safetractor UK Ltd | Information & communication | 2026 |
| Safety Compliance Partnership Ltd | Professional & scientific | 2012 |
| Safewire Electrical & Security Limited | Manufacturing | 2021 |
| Saffron & Slate Ltd | Administrative & support | 2025 |
| Saffron Spice York Ltd | Hospitality | 2024 |
| Saffron Walden Developments Limited | Construction | 2016 |
| Saffrons of York 2013 Limited | Wholesale & retail | 2012 |
| Sage & Pearl Ltd | Wholesale & retail | 2026 |
| Saggers & Gold Limited | Construction | 1997 |
| Sags Property Limited | Real estate | 2025 |
| Sags York Ltd | Hospitality | 2023 |
| Saher Tariq Ltd | Real estate | 2021 |
| SAI Properties York Ltd | Real estate | 2025 |
| Sajid Medico Limited | Health & social care | 2025 |
| Saksons Interiors Limited | Construction | 2014 |
| Sakura Future LLP | | 2017 |
| Sales Directors Yorkshire Limited | Wholesale & retail | 2016 |
| Salisbury Terrace Owners Club Limited | Households | 2014 |
| Salix Holiday Cottages (York) Ltd | Hospitality | 2023 |
| Sally Sleightholme Ltd | Agriculture & fishing | 2008 |
| Salon in the Square Limited | Other services | 2019 |
| Salonika Enterprises Ltd | Financial services | 2021 |
| Salonika Residential Estate Ltd | Real estate | 2021 |
| Salsa Pizza (York) Ltd | Hospitality | 2019 |
| Salt and Steam Ltd | Wholesale & retail | 2020 |
| Salt PIG Sandwiches Ltd | Hospitality | 2025 |
| Saltbox Build Ltd | Construction | 2021 |
| Saltbox Property Services Ltd | Real estate | 2020 |
| Salter Communications Ltd | Education | 2023 |
| Salterns (Terrington) Residents Management Company Limited | Households | 2017 |
| Saltersford Trading Limited | Professional & scientific | 2009 |
| Saltram Meadow Plymouth Management Company Limited | Households | 2014 |
| Saltstone Consulting Ltd | Information & communication | 2026 |
| Salty Pine Cones Limited | Real estate | 2001 |