| Social Work Assessments Limited | Health & social care | 2015 |
| Socket Store Limited | Wholesale & retail | 2010 |
| Soda Design Limited | Wholesale & retail | 2005 |
| Soft Suds Ltd | Other services | 2014 |
| Software Analysis Solutions Limited | Administrative & support | 2007 |
| Soho Fashion Market Limited | Extraterritorial | 2011 |
| Soho Market Limited | Extraterritorial | 2011 |
| Solace for Children Limited | Health & social care | 2017 |
| Solar Mounting Limited | Professional & scientific | 2022 |
| Solar Severn Electrical Ltd | Construction | 2024 |
| Solara Business Services Limited | Extraterritorial | 2012 |
| Solas Group Ltd | Manufacturing | 2015 |
| Sole Investments Worcester Ltd | Professional & scientific | 2023 |
| Sole Purpose Store Limited | Wholesale & retail | 2024 |
| Solicitors Defence Union Limited | Professional & scientific | 2006 |
| Solinus Consultancy Limited | Professional & scientific | 2022 |
| Solis Infotech Limited | Wholesale & retail | 2015 |
| Sololegal Limited | Professional & scientific | 2020 |
| Solos Holidays Limited | Extraterritorial | 2019 |
| Somers Road Property Limited | Hospitality | 2004 |
| Somerset Estates Partnership LLP | | 2014 |
| Somerset Estates Partnership Project Co Limited | Construction | 2015 |
| Sonkei Italy Ltd | Real estate | 2022 |
| Sonkei Ltd | Financial services | 2022 |
| SOP Technologies Limited | Professional & scientific | 2025 |
| Soul Groundworks Limited | Administrative & support | 2023 |
| Sound BET Media Limited | Professional & scientific | 2017 |
| Sound House Worcester Ltd | Wholesale & retail | 2025 |
| Soundnice Company | Professional & scientific | 1995 |
| Soup Ltd | Hospitality | 2018 |
| Source Green Limited | Wholesale & retail | 2022 |
| South Gloucestershire Care Services Limited | Health & social care | 2019 |
| South Midlands Psychologists Ltd | Health & social care | 2015 |
| South Quay (Worcester) Limited | Households | 1987 |
| South West Medical Limited | Wholesale & retail | 2000 |
| South West Sums Ltd | Professional & scientific | 2026 |
| Southampton Cedp LLP | | 2014 |
| Southampton Cedp Project Co. Limited | Construction | 2014 |
| Southco Europe Ltd. | Extraterritorial | 1984 |
| Southco Manufacturing Limited | Manufacturing | 2001 |
| Southdene Eleven Limited | Real estate | 2026 |
| Southfield Freehold Ltd | Financial services | 2023 |
| Southill MS Ltd | Professional & scientific | 2024 |
| Southwestface Limited | Financial services | 2024 |
| Southwood Land Limited | Hospitality | 2016 |
| Sovereign Star Limited | Wholesale & retail | 2025 |
| SP Automotive Limited | Wholesale & retail | 2025 |
| Spa Cleaning Services Limited | Construction | 2009 |
| Spa Independent Property Services Ltd | Real estate | 2019 |
| Spa Metal Roofing Limited | Construction | 2019 |
| Spa Pipe Supplies Limited | Other services | 2004 |
| Spa Security Ltd | Other services | 2016 |
| Space 001 Ltd | Real estate | 2017 |
| Space for Health Limited | Real estate | 2022 |
| Space to Ride Limited | Information & communication | 2025 |
| Spaghetti Structures Limited | Professional & scientific | 2013 |
| Spal Automotive (UK) Ltd. | Wholesale & retail | 1993 |
| Spanish Markets Limited | Professional & scientific | 2013 |
| Sparkle & Immaculate Services Ltd | Health & social care | 2024 |
| Sparkle Lets Limited | Real estate | 2024 |
| Sparkle Property Services Ltd | Construction | 2019 |
| Spartan Fire Protection Ltd | Construction | 2023 |
| Spartans Delivery Logistics Ltd | Transport & logistics | 2026 |
| Spats Coffee Shop Ltd | Hospitality | 2024 |
| SPB Parcels Ltd | Transport & logistics | 2015 |
| SPD Print Ltd | Manufacturing | 2005 |
| Speak Volumes Festival CIC | Arts & recreation | 2023 |
| Spears (Holdings) Ltd | Other services | 2019 |
| Specialised Camera Services Limited | Information & communication | 2004 |
| Specialised Hire Services Ltd | Transport & logistics | 2017 |
| Specialised Security Services Limited | Manufacturing | 2018 |
| Specialist Facades Ltd | Construction | 2024 |
| Specialist Surveying Services Ltd | Construction | 2021 |
| Speciality Food Service Limited | Wholesale & retail | 2005 |
| Spectrum Sports Ltd | Manufacturing | 2026 |
| Speedform Limited | Administrative & support | 2005 |
| Speedwell-Productions Limited | Arts & recreation | 2019 |
| Speedy Mobile Accessories Ltd | Wholesale & retail | 2023 |
| Speedyfit Limited | Energy | 2018 |
| Spencer Harris Advisory Limited | Professional & scientific | 2024 |
| Spetchley 70 Limited | Other services | 2014 |
| Spetchley Developments Limited | Construction | 2014 |
| Speyer Photonics Ltd | Professional & scientific | 2007 |
| Spice Bangla Limited | Hospitality | 2024 |
| Spike Milton Timber Services Limited | Agriculture & fishing | 2019 |
| Spilsbury & Jones Limited | Administrative & support | 2018 |
| Spin the Black Circle Ltd | Wholesale & retail | 2022 |
| Spin UK Ltd | Manufacturing | 1999 |
| Spinnerette Limited | Wholesale & retail | 2011 |
| Spiral Developments Limited | Real estate | 2003 |
| Spire Business Communications Limited | Wholesale & retail | 2002 |
| Spire Business Management Solutions Limited | Information & communication | 2014 |
| Spire Managed Services Limited | Information & communication | 2019 |
| Spire Systems Ltd | Information & communication | 2019 |
| Spire Technology Group Limited | Information & communication | 2019 |
| Spirit Executive Ltd | Administrative & support | 2013 |
| Spirit Marketing & Events Ltd | Extraterritorial | 2020 |
| Spirit of Sport UK Limited | Other services | 2021 |
| Spitalfields Festival Market Place Ltd | Extraterritorial | 2003 |
| Spitalfields Market Ltd | Extraterritorial | 2003 |