| Scrumbum Ltd | Wholesale & retail | 2019 |
| Scrutinor Limited | Professional & scientific | 2015 |
| Scyzor Ltd | Wholesale & retail | 2022 |
| SD Community CIC | Other services | 2026 |
| SDV Aurelian Ltd | Manufacturing | 2025 |
| SDW Professional Services Limited | Information & communication | 2009 |
| Seads Consultants Limited | Professional & scientific | 2020 |
| Search Rehab Ltd | Administrative & support | 2023 |
| Searchlight Resourcing Solutions Limited | Administrative & support | 2007 |
| Seascape Services Limited | Other services | 2023 |
| Seastone Driveways & Patios Ltd | Construction | 2025 |
| Seastyle Limited | Professional & scientific | 1985 |
| Seats and Sofas (UK) Limited | Wholesale & retail | 2007 |
| Sebright Holdings Ltd | Households | 2025 |
| Secc Kitchen Installations Limited | Construction | 2021 |
| Secret Garden Catering Ltd | Hospitality | 2025 |
| Secret Histories Ltd | Wholesale & retail | 2025 |
| Secure Window Systems Worcester Limited | Construction | 2025 |
| Security Patrol Services Limited | Professional & scientific | 2000 |
| Seegrow (Developments) Limited | Agriculture & fishing | 2012 |
| Seegrow Holdings Limited | Financial services | 2023 |
| Seegrow Solutions Agriculture Limited | Financial services | 2023 |
| Seegrow Solutions Limited | Agriculture & fishing | 2020 |
| Seegrow Solutions Sport Limited | Wholesale & retail | 2023 |
| Seek Cars Limited | Wholesale & retail | 2024 |
| Selac Ltd | Real estate | 2003 |
| Selbourne Homes Limited | Construction | 2001 |
| Select Investment Solutions Limited | Real estate | 2019 |
| Self Assessment Today Ltd | Professional & scientific | 2019 |
| Selina Richards Limited | Wholesale & retail | 2025 |
| Selita Service Limited | Wholesale & retail | 2025 |
| Semblent Limited | Information & communication | 2014 |
| Sensory Direct (UK) Limited | Manufacturing | 2008 |
| Sensory Products Limited | Manufacturing | 2010 |
| Seowise Ltd | Administrative & support | 2025 |
| Septimus Nominees Limited | Extraterritorial | 1935 |
| Sercal Materials Testing Machines Services Limited | Manufacturing | 1990 |
| Serlas Holdings Limited | Financial services | 2019 |
| Serlas Investments Ltd | Wholesale & retail | 2020 |
| Serrao Ltd | Construction | 2023 |
| Servicesync Operations Ltd | Administrative & support | 2025 |
| Seseme Ltd | Information & communication | 2016 |
| Setmate Limited | Information & communication | 2011 |
| Seven Star Rentals Limited | Real estate | 2014 |
| Seven Star Wraps Limited | Wholesale & retail | 2014 |
| Sevenoaks Trading Ltd | Hospitality | 2020 |
| Sevenomed Ltd | Health & social care | 2017 |
| SEVENSEVEN2 MX Ltd | Wholesale & retail | 2018 |
| Severn Angels Care Group Limited | Administrative & support | 2017 |
| Severn Angels Healthcare Ltd | Administrative & support | 2015 |
| Severn Applications Ltd | Information & communication | 2013 |
| Severn Arts | Education | 2017 |
| Severn Cleaning Ltd | Administrative & support | 2017 |
| Severn Consultancy Ltd | Professional & scientific | 2025 |
| Severn Event Services Limited | Administrative & support | 2025 |
| Severn Hotel Limited | Hospitality | 2025 |
| Severn Motor Yacht Club(Holdings)Company Limited(The) | Professional & scientific | 1937 |
| Severn Motorcycle Tours Ltd | Administrative & support | 2020 |
| Severn Rivers Ecology Limited | Professional & scientific | 2016 |
| Severn Rivers Trust | Agriculture & fishing | 2008 |
| Severn Ropes Ltd | Manufacturing | 2026 |
| Severn Security Services Limited | Administrative & support | 2015 |
| Severn Stoke Community Interest Company | Administrative & support | 2018 |
| Severn Surveys Ltd | Construction | 2024 |
| Severn Taxis (Worcester) Limited | Transport & logistics | 2021 |
| Severn Technologies & Trading Ltd | Wholesale & retail | 2025 |
| Severn Trade Frames Ltd | Construction | 2023 |
| Severn Vale Home Care Limited | Health & social care | 2020 |
| Severn Valley Auto Grass Club Limited | Arts & recreation | 1979 |
| Severn Valley Electricians Ltd | Construction | 2018 |
| Severn View Solutions Ltd | Wholesale & retail | 2019 |
| Severnside (Top Barn) Limited | Extraterritorial | 2015 |
| Severnside Hospitality Ltd | Financial services | 2026 |
| Severnsimplicity Ltd | Professional & scientific | 2025 |
| Sevilla Worcester Limited | Real estate | 2011 |
| Sevington Barns Management Limited | Households | 2007 |
| Sevnth Collective Ltd | Wholesale & retail | 2026 |
| Sewwandi Ltd | Health & social care | 2024 |
| Seymour Hotels Limited | Hospitality | 1993 |
| Seymour John (Shropshire) Limited | Professional & scientific | 2015 |
| Seymour John (Westmidlands) Limited | Professional & scientific | 2017 |
| Seymour John Limited | Information & communication | 2012 |
| Seymour John People and Change Limited | Professional & scientific | 2017 |
| Seymour John Public Services (East Anglia) Limited | Administrative & support | 2019 |
| Seymour John Public Services (London & South East) Limited | Administrative & support | 2019 |
| Seymour John Public Services (Midlands) Limited | Information & communication | 2016 |
| Seymour John Public Services (North) Limited | Professional & scientific | 2019 |
| Seymour John Public Services (South West) Limited | Administrative & support | 2019 |
| SF Murphy Associates Limited | Professional & scientific | 2011 |
| SFB Supplies Ltd | Wholesale & retail | 2019 |
| Sfsglobe Ltd | Wholesale & retail | 2021 |
| SG Ramps Limited | Administrative & support | 2018 |
| SGI Talent Group Ltd | Administrative & support | 2020 |
| SGM Studios Ltd | Information & communication | 2026 |
| Shadow Systems Limited | Professional & scientific | 2020 |
| Shakeeys Properties Limited | Real estate | 2014 |
| Shakespeare Court (Alcester) Management Company Limited | Households | 1991 |
| Shakespeare Rally Promotions Limited | Administrative & support | 2004 |
| Shala Ventures Ltd | Manufacturing | 2025 |
| Share Home Community CIC | Hospitality | 2023 |