| SA Medics Limited | Health & social care | 2019 |
| SAA Medical Services Ltd | Health & social care | 2026 |
| Saani PAR Ltd | Wholesale & retail | 2026 |
| SAB Property Trading Limited | Real estate | 2003 |
| Sabbath Energy Solutions Ltd | Construction | 2021 |
| Sabbath Wheels Ltd | Manufacturing | 2025 |
| Saber Hospitality Ltd | Financial services | 2024 |
| Sabrixis Limited | Information & communication | 2026 |
| SAC Lettings & Developments Limited | Other services | 2019 |
| Sadie N Dykes Limited | Professional & scientific | 2025 |
| Sadie Skipworth Social Media Limited | Professional & scientific | 2021 |
| Sadovi Ltd | Health & social care | 2023 |
| Safari Fairways Ltd | Administrative & support | 2024 |
| Safe and Efficient Care Limited | Health & social care | 2023 |
| Safeaspouses Ltd | Real estate | 2021 |
| Safeguarding Fundamentals Ltd | Professional & scientific | 2021 |
| Safer People Limited | Administrative & support | 2016 |
| Saffa Style Barber Ltd | Other services | 2025 |
| Saggar House Ltd | Real estate | 2026 |
| Sahak Group Ltd | Households | 2025 |
| Saint Marys Street Limited | Hospitality | 2026 |
| Sales Excellence Consulting Limited | Professional & scientific | 2009 |
| Sales Print Design Limited | Extraterritorial | 2020 |
| Sally Price Limited | | 1988 |
| Salter and Playdon Limited | Real estate | 2009 |
| Saltire Events Management Limited | Administrative & support | 2011 |
| SAM Cleaveley Limited | Hospitality | 2019 |
| SAM Orgee Pools & Landscaping Limited | Administrative & support | 2022 |
| SAM Roberts Hair Design Limited | Other services | 2003 |
| Samantha Keates Accountancy Ltd | Professional & scientific | 2018 |
| Samarkand Limited | Administrative & support | 2009 |
| Samrai Accountancy Services Ltd | Professional & scientific | 2011 |
| Samrose Growers Limited | Agriculture & fishing | 2021 |
| Samtom Limited | Professional & scientific | 2006 |
| Sam’S Taxis Ltd | Transport & logistics | 2024 |
| Sancaktar Limited | Hospitality | 2026 |
| Sanctuary (NW Management) Limited | Construction | 2003 |
| Sanctuary (Whitbourne) Limited | Agriculture & fishing | 1998 |
| Sanctuary Capital PLC | Real estate | 2009 |
| Sanctuary Care (North) Limited | Health & social care | 2014 |
| Sanctuary Care Limited | Health & social care | 2001 |
| Sanctuary Maintenance Contractors Limited | Real estate | 2009 |
| Sanctuary Management Services Limited | Real estate | 2001 |
| Sanctuary Pension Trustees Limited | Administrative & support | 2026 |
| Sanctuary Treasury Limited | Real estate | 2009 |
| Sandbox Investments Ltd | Real estate | 2020 |
| Sandbrook Limited | Professional & scientific | 2019 |
| Sandfield Engineering Company Limited | Manufacturing | 1965 |
| Sandhaven Homes Ltd | Real estate | 2026 |
| Sandhu Worcester Limited | Real estate | 2015 |
| Sandpitt Forge Limited | Agriculture & fishing | 2006 |
| Sandpitt Forge Supplies Limited | Agriculture & fishing | 1998 |
| Sandra Todd Nutrition Limited | Other services | 2026 |
| Sandringham Mews (Hampton) Management Limited | Real estate | 2002 |
| Sandwichsmiths Ltd | Hospitality | 2023 |
| Sangers Deli Ltd | Hospitality | 2021 |
| Sansome Lodge Limited | Hospitality | 2003 |
| Santé Plus Limited | Health & social care | 2020 |
| Sape Consulting Ltd | Professional & scientific | 2014 |
| Sapphire Medical Care Ltd | Health & social care | 2025 |
| Sapphire Spa Solutions Ltd | Administrative & support | 2018 |
| Sarah Gray Movement Ltd | Arts & recreation | 2023 |
| Saratoga Software (UK) Limited | Information & communication | 2021 |
| Sarnia Labs Ltd | Information & communication | 2025 |
| Sarplus Recruitment Limited | Administrative & support | 2025 |
| SAS Personnel Limited | Administrative & support | 2020 |
| SAS Properties (Worcs) Limited | Real estate | 2021 |
| Sassy Boutique Limited | Wholesale & retail | 2009 |
| Satel UK Limited | Information & communication | 2004 |
| Satisy Limited | Information & communication | 2024 |
| Sauce Creative Communications Limited | Professional & scientific | 2012 |
| Sawyer and SON Ltd | Professional & scientific | 2019 |
| Saxon CNC Limited | Manufacturing | 2023 |
| SB Jetting Limited | Administrative & support | 2018 |
| Sbci Ltd | Professional & scientific | 2025 |
| Sbfservices Ltd | Construction | 2014 |
| SBW Securities Limited | Financial services | 2022 |
| SC Property Installations Ltd | Manufacturing | 2025 |
| Scaffolding MDS Ltd | Construction | 2019 |
| Scaife Construction Services Limited | Construction | 2025 |
| Scale Global Limited | Professional & scientific | 2018 |
| Scales (Worcester) Ltd | Wholesale & retail | 2010 |
| Scan and Model Limited | Professional & scientific | 2017 |
| Scanwow Ltd | Information & communication | 2025 |
| Scaramanga Design Limited | Professional & scientific | 1998 |
| SCC Commercial Consultants Ltd | Professional & scientific | 2018 |
| SCG Cars Ltd | Wholesale & retail | 2015 |
| SCHEMA21 Ltd | Professional & scientific | 2016 |
| SCI Trading Ltd | Hospitality | 2019 |
| Scimitar Sports UK Ltd | Wholesale & retail | 2010 |
| SCO Solutions Limited | Professional & scientific | 2024 |
| Scopenext Limited | Manufacturing | 1999 |
| Scopenext Solutions Limited | Extraterritorial | 2008 |
| Scotchlec Limited | Construction | 2026 |
| Scott & Gillett Ltd. | Hospitality | 2025 |
| Scott James Construction Ltd | Construction | 2019 |
| Scottsdale Construction Ltd | Construction | 2021 |
| Scout & Stay Ltd | Real estate | 2026 |
| Script Haven Ltd | Wholesale & retail | 2022 |
| Scrub BJH Ltd | Administrative & support | 2025 |