| Scorpion Transport Ltd | Transport & logistics | 2025 |
| Scorpius Consulting Ltd | Information & communication | 2022 |
| Scotsdale PUB Co Ltd | Hospitality | 2020 |
| Scottie's Chicken Ltd | Hospitality | 2024 |
| Scotts Constructions Ltd | Construction | 2025 |
| SCR Capital Ltd | Professional & scientific | 2016 |
| Scrapuk Limited | Wholesale & retail | 2021 |
| Scrapzilla Breaker Limited | Wholesale & retail | 2026 |
| Screed Plus Ltd | Construction | 2024 |
| Screening Direct 4 U Ltd | Health & social care | 2019 |
| Scrubskwad Limited | Administrative & support | 2024 |
| SCT Development Limited | Professional & scientific | 2017 |
| Sculptedbysham Ltd | Other services | 2025 |
| SCW Investments Limited | Real estate | 2019 |
| SD Aesthetic House Ltd | Other services | 2026 |
| SD Carriers Ltd | Transport & logistics | 2024 |
| SD Goldberry Ltd | Real estate | 2023 |
| SDA Consultancy Solutions Limited | Professional & scientific | 2024 |
| SDB Construction Services Ltd | Construction | 2019 |
| Sddp Limited | Health & social care | 2016 |
| SDK Property Midlands Ltd | Real estate | 2021 |
| SDP Transport Ltd | Transport & logistics | 2024 |
| SDS Picwear Limited | Wholesale & retail | 2022 |
| SDS Properties and Accommodation Ltd | Real estate | 2024 |
| Sdsluk CIC | Real estate | 2025 |
| SDW Real Estate Limited | Real estate | 2016 |
| SE7ENTY2BIKES Limited | Wholesale & retail | 2017 |
| Sea Empress Investment Limited | Real estate | 2024 |
| Sea-Bed Solutions Limited | Mining & quarrying | 2012 |
| Seabrook Cars Ltd | Wholesale & retail | 2024 |
| Seacode Limited | Information & communication | 2023 |
| Seahawks Property Group Ltd | Real estate | 2025 |
| Sean O'Flaherty Contractors Limited | Construction | 2004 |
| Sean the Lawn Ltd | Administrative & support | 2018 |
| Seano Catering Limited | Hospitality | 2025 |
| Secret Angels WLV CIC | Other services | 2022 |
| Sector Switch Limited | Administrative & support | 2022 |
| Secure Children Homes Ltd | Health & social care | 2023 |
| Secure Cleaning Ltd | Administrative & support | 2016 |
| Secure Credit Limited | Financial services | 2009 |
| Secure Future Properties Ltd | Real estate | 2026 |
| Secure Healthcare Ltd | Administrative & support | 2015 |
| Secure Home Systems Ltd | Administrative & support | 2015 |
| Secure Talent Ltd | Administrative & support | 2016 |
| Secure Training Services Limited | Administrative & support | 2016 |
| Secure-A-Fence Ltd | Construction | 2018 |
| Secureit Bespoke Ltd | Professional & scientific | 2024 |
| Securelink Logistics Ltd | Wholesale & retail | 2026 |
| Securepoint MIS Limited | Administrative & support | 2026 |
| Securifys Pro Limited | Information & communication | 2026 |
| Security Consultancy Midlands Limited | Administrative & support | 2018 |
| Securvision Ltd | Administrative & support | 2020 |
| Sedag Care Ltd | Health & social care | 2021 |
| Sedehi Services Limited | Transport & logistics | 2018 |
| Sedgley Health Ltd | Wholesale & retail | 2025 |
| Sedgley Lodge Ltd | Construction | 2022 |
| Sedgley Management Ltd | Real estate | 2025 |
| Sedgs Agency Ltd | Information & communication | 2026 |
| Seedat Carpets Limited | Wholesale & retail | 2009 |
| Seedge Ltd | Administrative & support | 2019 |
| Seehra Holdings Ltd | Wholesale & retail | 2023 |
| Seek the Saviour Gospel Outreach | Wholesale & retail | 2024 |
| Seekoh International Limited | Information & communication | 2019 |
| Seerat Transport Limited | Transport & logistics | 2025 |
| Segit Firm Ltd | Professional & scientific | 2025 |
| Segpe Intl Ltd | Health & social care | 2022 |
| Sehaj Simar Ltd | Real estate | 2026 |
| Sein Developments Ltd | Real estate | 2026 |
| Seisdon Holdings Limited | Administrative & support | 2023 |
| Seisdon Ltd | Professional & scientific | 2006 |
| Seisdon Meadow Limited | Administrative & support | 2023 |
| Seisdon Properties Ltd | Real estate | 2025 |
| Seisdon Property Holdings Limited | Real estate | 2026 |
| Seisdon Walls and Patios Limited | Construction | 2002 |
| Sela Care Services Ltd | Transport & logistics | 2024 |
| Selah Tamil Church UK Ltd | Other services | 2025 |
| Select 'N' Save (W'Ton) Limited | Wholesale & retail | 2008 |
| Select 1 Automotive Ltd | Wholesale & retail | 2015 |
| Select a Good Cause Limited | Other services | 2017 |
| Select Business Finance Limited | Financial services | 2010 |
| Select Eco Limited | Construction | 2023 |
| Select Electrical Installations Limited | Construction | 2019 |
| Select Financial Investments Limited | Financial services | 2015 |
| Select Fire Systems Limited | Extraterritorial | 2020 |
| Select Health Care (Developments) Limited | Health & social care | 2006 |
| Select Health Care Group Ltd | Financial services | 2020 |
| Select Health Care Services Limited | Health & social care | 2017 |
| Select Installation Services Limited | Construction | 2016 |
| Select Networking LLP | | 2024 |
| Select Property Adaptations Ltd | Construction | 2025 |
| Select Services Holdings Limited | Financial services | 2017 |
| Selectech Solutions Ltd | Administrative & support | 2020 |
| Self Assessment Online Limited | Professional & scientific | 2012 |
| Self Develop Training Limited | Extraterritorial | 2025 |
| Self Empowerment Foundation | Education | 2025 |
| Sell Fonez Limited | Wholesale & retail | 2015 |
| Sellnex Ltd | Wholesale & retail | 2026 |
| Sellnexa Ltd | Wholesale & retail | 2026 |
| Selltrixa Ltd | Wholesale & retail | 2026 |
| Sellzeno Ltd | Wholesale & retail | 2026 |