| Semantic Standards Authority Limited | Professional & scientific | 2026 |
| Sempreuk Ltd | Wholesale & retail | 2022 |
| Senderooo Ltd | Financial services | 2025 |
| Senior UK (Midlands) Limited | Real estate | 2023 |
| Senri Consultancy Ltd | Professional & scientific | 2021 |
| Sensational Foods Limited | Hospitality | 2018 |
| Sense Solutions Ltd | Professional & scientific | 2016 |
| Sensory Wise Ltd | Education | 2014 |
| Sentinel Fire Door Compliance Ltd | Administrative & support | 2026 |
| Sentry Electrical Services Limited | Construction | 2009 |
| Senwod Contracting Limited | Construction | 2003 |
| SEO City Ltd | Professional & scientific | 2026 |
| SEO Elite Studio Ltd | Professional & scientific | 2024 |
| SEO Labs Ltd | Information & communication | 2012 |
| SEO Link Buildiing Solutions Limited | Information & communication | 2024 |
| Seohub Ltd | Professional & scientific | 2025 |
| Seoquill Limited | Information & communication | 2024 |
| September Pink Limited | Arts & recreation | 2010 |
| Serafyer Ltd | Wholesale & retail | 2026 |
| Seraph Investments Ltd | Wholesale & retail | 2021 |
| Serbasts Delivery Ltd | Transport & logistics | 2026 |
| Serco (Plastic Injection Moulders) Limited | Manufacturing | 1988 |
| Serdogs Ltd | Information & communication | 2026 |
| Seren Laboratory Services Limited | Professional & scientific | 1996 |
| Serene Real Estates Ltd | Real estate | 2024 |
| Serenity Always Ltd | Health & social care | 2014 |
| Serenity Homecare Limited | Health & social care | 2010 |
| Serenity Lodge Limited | Other services | 2010 |
| Serenity Touch Ltd | Other services | 2025 |
| Serenity V Homes Limited | Real estate | 2025 |
| Serenitybell Ltd | Wholesale & retail | 2019 |
| Serevents Limited | Other services | 2022 |
| Sergiomumba Limited | Health & social care | 2023 |
| Sergiss Ltd | Construction | 2024 |
| Sergiu Restea Limited | Transport & logistics | 2022 |
| Sermon Healthcare Ltd | Administrative & support | 2020 |
| Serp Insight Ltd | Information & communication | 2023 |
| Serpinn Ltd | Information & communication | 2023 |
| Servbest Limited | Administrative & support | 2022 |
| Service My Boiler Ltd | Construction | 2010 |
| SERVICES4SCHOOLS Limited | Education | 2013 |
| Serviticum (Chestall) Limited | Agriculture & fishing | 1994 |
| SET Go Active Ltd | Wholesale & retail | 2025 |
| Setca Ltd | Information & communication | 2024 |
| Setpace Limited | Information & communication | 2016 |
| Setrox Limited | Other services | 2022 |
| Sevalink Ltd | Professional & scientific | 2025 |
| Seven Branded Limited | Wholesale & retail | 2024 |
| Seven Skies Solutions Limited | Administrative & support | 2020 |
| Seven Sky Ltd | Wholesale & retail | 2025 |
| Seven Stars Management Company 23 Ltd | Households | 2023 |
| Seven Storeys Property Group Limited | Real estate | 2025 |
| Sevenrose Ltd | Administrative & support | 2002 |
| Seventh Circle - Artworks & Aesthetics Ltd | Manufacturing | 2019 |
| Severn Futures Limited | Construction | 2009 |
| Severn Grange Developments LLP | | 2009 |
| Severnside Scaffolding Specialists Ltd | Construction | 2024 |
| Sewa Centre Ltd | Health & social care | 2010 |
| Seymour Green Horticulture Centre Limited | Wholesale & retail | 2011 |
| SFC (Europe) Ltd | Manufacturing | 2012 |
| SFY Traders Limited | Wholesale & retail | 2025 |
| SG Freight Limited | Transport & logistics | 2025 |
| SG Habitats Limited | Real estate | 2022 |
| SG Imports and Exports Ltd | Wholesale & retail | 2022 |
| SG Interior Ltd | Construction | 2018 |
| SG Jewels Ltd | Manufacturing | 2026 |
| SG Medica Ltd | Wholesale & retail | 2024 |
| SG Property Lettings Limited | Real estate | 2020 |
| SG Trading Services Limited | Professional & scientific | 2019 |
| SGK Business Support Services Ltd | Administrative & support | 2025 |
| SGR Contractors Ltd | Construction | 2021 |
| SGR Investments Ltd | Real estate | 2020 |
| SGS Systems Limited | Construction | 2004 |
| SGT Courier Services Limited | Transport & logistics | 2018 |
| SGT. Pepper’S Friends CIC | Other services | 2022 |
| SH Celebrations Ltd | Wholesale & retail | 2026 |
| SH Click Ltd | Wholesale & retail | 2026 |
| SH GAS and Heating Ltd | Construction | 2023 |
| SH Square Media Ltd | Information & communication | 2026 |
| Shabad Driveway & Construction Ltd | Construction | 2024 |
| Shabana Food Ltd | Hospitality | 2022 |
| Shabnam Shah Ltd | Wholesale & retail | 2025 |
| Shadi Sweets Limited | Hospitality | 2025 |
| Shadow Cars Limited | Wholesale & retail | 2021 |
| Shadowshine Limited | Financial services | 2018 |
| Shaeen Logistics Ltd | Transport & logistics | 2025 |
| Shafique Estate Ltd | Real estate | 2020 |
| Shafquat Consulting Limited | Health & social care | 2013 |
| Shaftesbury Solutions Ltd | Information & communication | 2012 |
| Shah G Motors Ltd | Wholesale & retail | 2024 |
| Shah G Properties Ltd | Real estate | 2026 |
| Shah Shawarma Ltd | Hospitality | 2026 |
| Shahbaba Ltd | Wholesale & retail | 2025 |
| Shahcreations Limited | Wholesale & retail | 2025 |
| Shaho's Kebab Ltd | Hospitality | 2025 |
| Shahwaiz Ahmed Ltd | Wholesale & retail | 2025 |
| Shahzad ALI Investments Ltd | Financial services | 2023 |
| Shahzad ALI Trading Ltd | Financial services | 2023 |
| Shakhawan ALI Ltd | Administrative & support | 2025 |
| Shalene Gordon Limited | Administrative & support | 2019 |