| Stephen Chapman Transport Limited | Transport & logistics | 2014 |
| Stephen Hopkins IFA Limited | Financial services | 2011 |
| Stephen J Price Limited | Professional & scientific | 2007 |
| Stephen Lagocki Medical Consulting Limited | Health & social care | 2021 |
| Stephen Lawrence Business Consultant Limited | Professional & scientific | 2014 |
| Stephenson Nautical Services Ltd | Transport & logistics | 2013 |
| Stepping Stone (UK) Ltd. | Professional & scientific | 2009 |
| Stepping Stones Support Services Ltd | Health & social care | 2026 |
| Steropar Limited | Information & communication | 2022 |
| Stev Blackwood Limited | Other services | 2018 |
| Steve Elliott Training Limited | Education | 2011 |
| Steve Tsoi Brand Consulting Limited | Professional & scientific | 2023 |
| Steve Woods Education Ltd | Information & communication | 2019 |
| Steven Belmar & Liston Funeral Directors Ltd | Other services | 2005 |
| Steven Caine Limited | Administrative & support | 2003 |
| Stewart Brickwork & Building Contractors NW Limited | Construction | 2022 |
| Stewart Brickwork and Building Contractors Ltd | Construction | 2019 |
| Stitch Collaboration Ltd | Professional & scientific | 2023 |
| STJ Property Developers Limited | Real estate | 2025 |
| Stlp Project Management Ltd | Administrative & support | 2016 |
| Stolley Event Services Limited | Arts & recreation | 2004 |
| Stone Oak Financial Planning Ltd | Professional & scientific | 2026 |
| Stonechat Digital Limited | Information & communication | 2019 |
| Stonegres Consultng Limited | Construction | 2013 |
| Stonegres Limited | Administrative & support | 2008 |
| Stonegres Supply Ltd | Construction | 2013 |
| Stonehill Consultancy Limited | Professional & scientific | 2017 |
| Stopsley Village Cars Ltd | Wholesale & retail | 2011 |
| Storepair Ltd | Transport & logistics | 2022 |
| Storeton Belted Galloways Ltd | Wholesale & retail | 2023 |
| Storeton Consultancy Ltd | Professional & scientific | 2026 |
| Storeton Developments Ltd | Construction | 2024 |
| Storeton Digital Limited | Information & communication | 2025 |
| Storeton Farm Equestrian Limited | Financial services | 2021 |
| Storeton Hall Farm Limited | Agriculture & fishing | 1962 |
| Storeton Rose Wills and Estates Limited | Professional & scientific | 2024 |
| Stories Spa Limited | Other services | 2025 |
| Stories Therapy Limited | Health & social care | 2025 |
| Storm Hockey Limited | Wholesale & retail | 2020 |
| Stormforce Limited | Wholesale & retail | 2023 |
| Strategic Management Accounting Ltd | Professional & scientific | 2023 |
| Strategic Marine Limited | Professional & scientific | 2009 |
| Stratherric Management Limited | Real estate | 2003 |
| Strato Solutions Limited | Information & communication | 2011 |
| Stratton Ventures Ltd | Construction | 2026 |
| Strawberry Productions Ltd | Information & communication | 2022 |
| Straylight Research Ltd | Information & communication | 2025 |
| Stream Engineering Solutions Limited | Professional & scientific | 2003 |
| Stretch-Uk Limited | Other services | 2025 |
| Stride 2020 CIC | Education | 2020 |
| Structured Knowledge Limited | Professional & scientific | 2014 |
| Stuart Conner Tech Docs Ltd | Administrative & support | 2018 |
| Stuart Reilly Financial Services Ltd | Financial services | 2016 |
| Stubborn Mule Ltd | Administrative & support | 2011 |
| Studio Ding Ltd | Professional & scientific | 2015 |
| Studio Kettle Limited | Administrative & support | 2007 |
| Studio Launch Ltd | Information & communication | 2025 |
| Studio LIV Ltd | Other services | 2020 |
| Studio Marsea Limited | Extraterritorial | 2025 |
| Study Space Academy Ltd | Education | 2024 |
| Stunners Properties Limited | Construction | 1996 |
| Stuste Design Limited | Professional & scientific | 2026 |
| Styles Property Investments Limited | Real estate | 2024 |
| Suardiaz UK Limited | Transport & logistics | 2006 |
| Sub-Urbia Inc Ltd | Hospitality | 2025 |
| Subskimmer Ltd | Manufacturing | 2008 |
| Substation Electrical Ltd | Construction | 2020 |
| Success Prospecting Limited | Professional & scientific | 2024 |
| Sugar and Silk Events Ltd | Hospitality | 2025 |
| Sugarsnap Marketing Ltd | Administrative & support | 2025 |
| Sullivan IT Limited | Information & communication | 2025 |
| Summit Energy Services Ltd | Manufacturing | 2026 |
| Summit Health & Performance Ltd | Arts & recreation | 2024 |
| Sun Bear Brewing Ltd | Manufacturing | 2022 |
| Sunbeam Healthcare Limited | Education | 2016 |
| Sunflowers Children's Yoga Therapy C.I.C. | Health & social care | 2021 |
| Sunlight Cleaners Limited | Other services | 2021 |
| Sunlight Restaurant Ltd | Hospitality | 2019 |
| Sunlight Roofing Services Ltd | Construction | 2023 |
| Sunlight Vision Limited | Wholesale & retail | 1999 |
| Sunnymeade Properties Ltd | Real estate | 2025 |
| Sunshine Digit Limited | Wholesale & retail | 2025 |
| Sunshine Entertainment Limited | Arts & recreation | 2017 |
| Sunshine Properties Wirral Limited | Real estate | 2026 |
| Sunte Ltd | Professional & scientific | 2025 |
| Superbright Ltd | Information & communication | 2016 |
| Superior Events Solutions Ltd | Administrative & support | 2024 |
| Supermove Removals and Storage Limited | Transport & logistics | 2017 |
| Supertechz Limited | Other services | 2023 |
| Supplied MEN & 4X4 Pickups Ltd | Arts & recreation | 2017 |
| Supply Chain Designz Limited | Professional & scientific | 2009 |
| Support Driving School Ltd | Education | 2025 |
| Supporting the Peeps Wirral CIC | Hospitality | 2022 |
| Supr Safety Limited | Wholesale & retail | 2019 |
| Supra Terra SUB Mari Ltd | Manufacturing | 2026 |
| Supreme Computer Services Ltd | Information & communication | 2023 |
| SUPREME13S Ltd | Administrative & support | 2022 |
| Sure Antennas Ltd | Wholesale & retail | 2020 |
| Sure Engineering Services Ltd | Information & communication | 2020 |
| Surva Limited | Professional & scientific | 2018 |