| Surya Satheesh Medicare Limited | Health & social care | 2025 |
| Sustain AI Ltd | Information & communication | 2022 |
| Sustainable Tomorrow Ltd | Education | 2020 |
| Suzie K Limited | Wholesale & retail | 2019 |
| Svantero Ltd | Professional & scientific | 2024 |
| Svaprogress Limited | Real estate | 2018 |
| Svasti Life Limited | Health & social care | 2026 |
| SVR Safety Limited | Professional & scientific | 2020 |
| SW Perfectsmile Limited | Health & social care | 2009 |
| SW Rentals Limited | Real estate | 2025 |
| Swaj Limited | Health & social care | 2019 |
| Swat Training Devices Limited | Wholesale & retail | 2012 |
| Sweet Mango Productions Ltd | Information & communication | 2012 |
| Sweet Tiers Ltd | Hospitality | 2025 |
| Sweethearts and Studs Ltd | Other services | 2025 |
| Sweetpea and IVY Floral Design Limited | Wholesale & retail | 2024 |
| Swift Bites (Bebington) Ltd | Hospitality | 2024 |
| Swift Data Analytics Ltd | Professional & scientific | 2023 |
| Swift Response Limited | Construction | 2013 |
| Swift Search Ltd | Administrative & support | 2023 |
| Swiftal Products Ltd | Wholesale & retail | 2024 |
| Swish Energy Limited | Administrative & support | 2023 |
| Switch Installation Limited | Wholesale & retail | 2014 |
| Switchgear and Cable Accessories Limited | Wholesale & retail | 2007 |
| SWM Site Solutions Ltd | Professional & scientific | 2015 |
| SWW7 Ltd | Real estate | 2020 |
| Sygnet Services Limited | Financial services | 2015 |
| Sylhet Spice Wirral Limited | Hospitality | 2025 |
| Symbiosys Systems Limited | Information & communication | 2005 |
| Symphony Cars Limited | Wholesale & retail | 2012 |
| Sync Apps Limited | Information & communication | 2023 |
| Synced Construction Ltd | Construction | 2025 |
| Synthverse Limited | Information & communication | 2024 |
| Systemic Automation and Controls Ltd | Professional & scientific | 2009 |
| Systemic Engineering Group Ltd | Professional & scientific | 2004 |
| Systemic Risk Management Ltd | Professional & scientific | 2009 |
| Systemic Software Solutions Ltd | Professional & scientific | 2009 |
| SYV Group Ltd | Real estate | 2022 |
| T 1 Big Ltd | Hospitality | 2024 |
| T & H Services Ltd | Administrative & support | 2023 |
| T & J Properties (NW) Ltd | Real estate | 2025 |
| T C Trading (NW) Limited | Wholesale & retail | 2014 |
| T E Auto Electrical Services Limited | Manufacturing | 2015 |
| T J Services (Wirral) Ltd | Wholesale & retail | 2017 |
| T Johnson FBA Ltd | Wholesale & retail | 2023 |
| T L Training Limited | Education | 2015 |
| T Millard Property Ltd | Real estate | 2024 |
| T Noyce Ltd | Professional & scientific | 2025 |
| T Plastering Solutions Ltd | Construction | 2026 |
| T&I Joinery Limited | Construction | 2017 |
| T&T Sunny Group Limited | Professional & scientific | 2021 |
| T. Tache Limited | Administrative & support | 2021 |
| T.B Electrical Limited | Construction | 2024 |
| T.C.D.Safety Ltd | Professional & scientific | 2022 |
| T.M. Brickwork Limited | Construction | 2004 |
| T.Telecom Consulting Ltd | Information & communication | 2014 |
| T4 Engineering Group Ltd | Manufacturing | 2025 |
| TA Engineering Ltd | Professional & scientific | 2016 |
| TA Palmer Consultancy Limited | Professional & scientific | 2026 |
| Table Alchemy Ltd | Other services | 2021 |
| Tabularium Ltd | Professional & scientific | 2015 |
| Tacklestorageuk Ltd | Wholesale & retail | 2025 |
| Tacos Chicken & Deserts Limited | Hospitality | 2024 |
| Tactus Events Ltd | Arts & recreation | 2022 |
| TAG 1 Limited | Real estate | 2022 |
| Tagveteransgroup Ltd | Transport & logistics | 2019 |
| Taib Restaurant Ltd | Hospitality | 2025 |
| Taihona Ltd | Information & communication | 2025 |
| Tailored Solutions (Stamford) Limited | Professional & scientific | 2019 |
| Tailored Yarn CIC | Information & communication | 2020 |
| Taking Strides Ltd | Health & social care | 2025 |
| Talaria Technology Limited | Professional & scientific | 2020 |
| Tale House Ltd | Real estate | 2022 |
| Talk 2 ANA Ltd | Health & social care | 2025 |
| Talk About Town Ltd | Other services | 2014 |
| Talk Sense Ltd | Professional & scientific | 2022 |
| Talking Life Ltd | Other services | 1990 |
| Talking Therapeutics Limited | Health & social care | 2016 |
| Tallbrook Ltd | Wholesale & retail | 2003 |
| Talvon Ltd | Administrative & support | 2025 |
| Talwar Consulting Services Limited | Administrative & support | 2017 |
| Tameside Leisure Shop Direct Limited | Wholesale & retail | 2025 |
| TAN Box Bromborough Limited | Other services | 2017 |
| Tangleha Ltd | Professional & scientific | 2023 |
| Tanglewood Destination Consulting Ltd | Professional & scientific | 2025 |
| Tango Property Investments Ltd | Construction | 2026 |
| Tannequip Global Limited | Wholesale & retail | 2010 |
| Tanning Studio (Liverpool) Ltd | Construction | 2025 |
| TAP Down Ltd | Information & communication | 2025 |
| Tara LEE (UK) Limited | Manufacturing | 2004 |
| Taraki Ltd | Wholesale & retail | 2020 |
| Tarbh Project Services Limited | Professional & scientific | 2014 |
| Target Property Consultancy Limited | Administrative & support | 2018 |
| Tarran Way North Estates Limited | Real estate | 1982 |
| Tarrawonga Consulting Limited | Information & communication | 2014 |
| Tasman Investments Ltd | Real estate | 2020 |
| Tastan Bebington Ltd | Other services | 2019 |
| Tastan(Uk) Ltd | Other services | 2018 |
| Tastebuds Nursery Food Limited | Extraterritorial | 2011 |
| Tasvir Khana Ltd | Professional & scientific | 2023 |