| Spicy Kitchen (NW) Ltd | Hospitality | 2011 |
| Spindler Property Limited | Real estate | 2024 |
| Spindrift Property Management Ltd | Real estate | 2024 |
| Spink Telecom Consultants Limited | Information & communication | 1999 |
| Spiral Interior Systems Limited | Construction | 2023 |
| Spiritual Crisis Network | Other services | 2008 |
| Spital Heating Limited | Construction | 2007 |
| SPJ Property Holdings Limited | Real estate | 2026 |
| SPJ Solutions Limited | Administrative & support | 2021 |
| Splatform Solutions Ltd | Information & communication | 2025 |
| Spline Ltd | Professional & scientific | 2007 |
| Split Perspectivz CIC | Education | 2020 |
| Spode Media Ltd | Information & communication | 2024 |
| Spookton Brew Co Ltd | Manufacturing | 2021 |
| Sporting John Limited | Real estate | 1976 |
| Sportopia Merseyside Ltd | Education | 2025 |
| Sports for Champions UK C.I.C. | Health & social care | 2024 |
| Sportsmates Limited | Arts & recreation | 2024 |
| Sporty Sports Ltd | Wholesale & retail | 2012 |
| SPR Property Limited | Real estate | 2022 |
| Spring Forth Health Care Ltd | Health & social care | 2018 |
| Spring Meadows Court Management Company Limited | Administrative & support | 2011 |
| Spring Vale Group Limited | Professional & scientific | 2019 |
| Springpath Communications Limited | Information & communication | 2020 |
| Springthorn Management Limited | Professional & scientific | 2019 |
| Sprint Consulting Ltd | Information & communication | 2007 |
| SPS Financial Management Limited | Professional & scientific | 2022 |
| SPS Home Improvements NW Limited | Construction | 2022 |
| SPS Wellbeing Limited | Arts & recreation | 2024 |
| Spvg Operation and Maintenance Ltd | Construction | 2025 |
| SPW Engineering Ltd | Other services | 2022 |
| Squirrel Electrics Ltd | Construction | 2025 |
| SR (Wirral) Ltd | Extraterritorial | 2020 |
| SR Consultants NW Ltd | Professional & scientific | 2025 |
| SR Prestige Autos Ltd | Wholesale & retail | 2023 |
| Srcra Ltd | Construction | 2025 |
| SRI Operations Ltd | Administrative & support | 2026 |
| Srini UK Ltd | Wholesale & retail | 2021 |
| SRK Total Solutions Limited | Administrative & support | 2014 |
| Srpa Ltd | Administrative & support | 2019 |
| SRS Projects Ltd | Construction | 2008 |
| Sryan Ltd | Information & communication | 2023 |
| SS Consultants (N.W.) Ltd | Health & social care | 2023 |
| Ssjs Holdings Limited | Water & waste | 2023 |
| SSS75 Ltd | Real estate | 2025 |
| ST Demolition Limited | Water & waste | 2025 |
| ST ELM Estates Ltd | Real estate | 2024 |
| ST ELM Limited | Financial services | 2024 |
| ST Flooring Solutions Ltd | Construction | 2022 |
| ST George's Heritage Ltd | Financial services | 2023 |
| ST James Gardens (Birkenhead) Management Company Limited | Real estate | 2007 |
| ST John's PRE School Limited | Education | 2014 |
| ST Michaels Investments Ltd | Professional & scientific | 2017 |
| Stable Site Services Limited | Construction | 2025 |
| Stables Close Residents Management Company Limited | Households | 2022 |
| Stacibliss Wordworks Limited | Health & social care | 2025 |
| Stack & Pixel Limited | Information & communication | 2026 |
| Stack Technologies Ltd | Information & communication | 2011 |
| Stacks Manchester Ltd | Hospitality | 2024 |
| Stage Developments Ltd | Real estate | 2022 |
| Stained Glass Knight Limited | Wholesale & retail | 2025 |
| Staingard Ltd | Financial services | 2006 |
| Stairlift Worx Ltd | Wholesale & retail | 2021 |
| Stampdco Limited | Wholesale & retail | 2020 |
| Standout Wine Ltd | Professional & scientific | 2022 |
| Standsure PM Limited | Professional & scientific | 2022 |
| Stanry Limited | Real estate | 2016 |
| Stanton Wirral Limited | Information & communication | 2017 |
| Stapledon Estate Agents Ltd | Real estate | 2025 |
| Stapledon Woods Nurseries Ltd | Agriculture & fishing | 2024 |
| Star East Business Ltd | Professional & scientific | 2022 |
| Star Matrix Logistics Ltd | Transport & logistics | 2025 |
| Starfruits Network Ltd | Other services | 2012 |
| Starlight City Ltd. | Extraterritorial | 2021 |
| Starlight Group NW Limited | Construction | 2023 |
| Starlotte Ltd | Other services | 2019 |
| Starry Night Staycations Ltd | Hospitality | 2025 |
| Starship Building Systems Limited | Construction | 2019 |
| Starship Developments Highground Limited | Construction | 2021 |
| Starship Developments Limited | Construction | 2020 |
| Starship Developments Sandlea View Limited | Construction | 2020 |
| Starship Developments Wirral 2 Limited | Construction | 2021 |
| Starship Regeneration Egerton Village Limited | Construction | 2022 |
| Starstead Properties Limited | Real estate | 2025 |
| Stashy Scrunchie Ltd | Wholesale & retail | 2021 |
| Station 1 Limited | Construction | 2013 |
| Stats-Search.Co.Uk Limited | Professional & scientific | 2018 |
| Statsdirect Limited | Information & communication | 2002 |
| Stay Simple Ltd | Hospitality | 2026 |
| Steady Starts Ltd | Manufacturing | 2026 |
| Steak House(Uk) Ltd | Hospitality | 2019 |
| Steel Bespoke Fabrication Ltd | Manufacturing | 2025 |
| Steele Clean Property Maintenance Limited | Administrative & support | 2020 |
| Steer Financial Limited | Administrative & support | 2019 |
| Stellar PA Ltd | Administrative & support | 2024 |
| Stellar QS Services Limited | Professional & scientific | 2006 |
| Stellarcare NW Limited | Health & social care | 2021 |
| Stema Property Ltd | Financial services | 2022 |
| Stemkids Limited | Education | 2017 |
| Stephanides Limited | Extraterritorial | 2011 |