| Smart Progress Ltd | Education | 2019 |
| Smart Repairs 4U Ltd | Other services | 2023 |
| Smart Repairs PVT Ltd | Other services | 2025 |
| Smartletuk Limited | Real estate | 2025 |
| Smartlivinguk Limited | Construction | 2020 |
| Smartregister Limited | Professional & scientific | 2003 |
| Smartsell for YOU Limited | Wholesale & retail | 2011 |
| Smash Kitchens NW Ltd | Hospitality | 2025 |
| Smashie's Moreton Ltd | Hospitality | 2024 |
| Smashies Moreton NW Ltd | Hospitality | 2025 |
| SMC Accounting Solutions Ltd | Professional & scientific | 2023 |
| SMD Supplies Ltd | Wholesale & retail | 2023 |
| SME Interim Limited | Professional & scientific | 2009 |
| Smginnovative Ltd | Professional & scientific | 2024 |
| Smile Financial Services Ltd | Financial services | 2020 |
| Smiles With AMY Limited | Health & social care | 2020 |
| Smith & Taylor Group Ltd | Information & communication | 2023 |
| Smith and Goldberg Limited | Wholesale & retail | 2019 |
| Smith Brothers Construction Ltd | Construction | 2026 |
| Smith Mechanical Services Limited | Construction | 2025 |
| Smith Reinforcements Limited | Construction | 2008 |
| Smith's (Wirral) Ltd | Other services | 2015 |
| Smith's Metalwork Designs Limited | Manufacturing | 2007 |
| Smiths Cabin Services Ltd | Manufacturing | 2021 |
| Smiths Electrical Supplies Limited | Wholesale & retail | 2017 |
| SMK Automotive @ JCT 1 Limited | Wholesale & retail | 2023 |
| SMR Supplies Limited | Wholesale & retail | 2013 |
| SMS Developments Ltd | Real estate | 2026 |
| SMS Property NW Limited | Real estate | 2024 |
| Smugglers Cove Bebington Ltd | Hospitality | 2026 |
| Smugglers Inns Distillery Ltd | Manufacturing | 2025 |
| Smugglers Inns Ltd | Hospitality | 2026 |
| SN3D Print Ltd | Manufacturing | 2024 |
| Snap One UP Limited | Wholesale & retail | 2015 |
| Snowy's Junior Golf Tour Ltd | Arts & recreation | 2024 |
| SO Digital Marketing Ltd | Information & communication | 2017 |
| SO Smart Marketing Limited | Professional & scientific | 2023 |
| Soccergods Limited | Arts & recreation | 2013 |
| Social Bridge Solutions Ltd | Professional & scientific | 2026 |
| Social Sparks Ltd | Hospitality | 2019 |
| Soilstice Design Ltd | Professional & scientific | 2026 |
| Soiree Design Studio UK Ltd | Other services | 2023 |
| Sojo Properties Ltd | Real estate | 2021 |
| SOL Accountancy & Tax Ltd | Professional & scientific | 2023 |
| SOL PV Group Limited | Construction | 2014 |
| Solar Install Ltd | Construction | 2026 |
| Solarfence UK Ltd. | Other services | 2023 |
| Sold My Soul Limited | Other services | 2025 |
| Soldo Property Investments Ltd | Real estate | 2020 |
| Solex Solar Ltd | Construction | 2026 |
| Solhäst Limited | Manufacturing | 2024 |
| Solid Earth Productions Ltd | Arts & recreation | 2023 |
| Solid State Dynamics Limited | Transport & logistics | 2016 |
| Solipsys Limited | Education | 1995 |
| Solunify Creations Ltd. | Information & communication | 2023 |
| Solutions to Care Ltd | Professional & scientific | 2016 |
| Somerset Groundworks Wirral Ltd | Construction | 2008 |
| Somerset House Property Management Limited | Households | 2020 |
| Somoco Ltd | Administrative & support | 2014 |
| Sonic View Limited | Information & communication | 2011 |
| Sonning Express Store Ltd | Wholesale & retail | 2024 |
| Sonsproud Investments Limited | Real estate | 1960 |
| SOS Uniforms UK Ltd | Health & social care | 2022 |
| Soul Awakening Academy Ltd | Education | 2017 |
| Soul Sisters Scooter Club CIC | Other services | 2024 |
| Soulgarden Healing Arts Ltd | Health & social care | 2023 |
| Sound Mind Psychotherapy Service Ltd | Health & social care | 2016 |
| SOURCE2SOUL Healing Limited | Education | 2021 |
| South Literary Limited | Arts & recreation | 2019 |
| South Wirral Nursing Services Ltd | Health & social care | 2020 |
| SP & J Property Limited | Real estate | 2017 |
| SP Roofing NW Ltd | Construction | 2026 |
| Space for Everyone Ltd | Hospitality | 2023 |
| Space to Learn Ltd | Education | 2022 |
| Spadan Planning Ltd | Construction | 2022 |
| Spanish Tots & Bebés Chester and Ellesmere Port Ltd | Health & social care | 2026 |
| Spanish Tots Ltd | Health & social care | 2021 |
| Sparc (NW) Ltd | Health & social care | 2025 |
| Sparks Lane Engineering Limited | Manufacturing | 2025 |
| Sparselent Ltd | Administrative & support | 2018 |
| Spatialapp Consulting Ltd | Other services | 2013 |
| Specialised Inflatable Technology Limited | Manufacturing | 2008 |
| Specialised Reporting Ltd | Professional & scientific | 2022 |
| Specialised Training UK Limited | Administrative & support | 2015 |
| Specialist Legal Consultants Limited | Professional & scientific | 2020 |
| Specialist Light & Power Ltd | Construction | 2026 |
| Specialist Medical Systems Limited | Health & social care | 2025 |
| Specialist Offshore Services Ltd | Transport & logistics | 2020 |
| Specialist Restoration UK Ltd | Administrative & support | 2025 |
| Specialist Social Work Training Ltd | Education | 2026 |
| Speciality Care Services Ltd | Health & social care | 2022 |
| Spectrum Heating Ltd | Construction | 2014 |
| Spectrum Security Systems Limited | Manufacturing | 2010 |
| Speechleys Limited | Professional & scientific | 2000 |
| Speedwell Consulting Ltd | Information & communication | 2022 |
| Speirs Subsea Services Limited | Professional & scientific | 2014 |
| Spektaglaze Alufolds Ltd | Construction | 2019 |
| Spendless Discounts (North West) Limited | Wholesale & retail | 2015 |
| SPF Locum Ltd | Health & social care | 2022 |
| Sphynx Energy Ltd | Construction | 2023 |