| SAM11 Limited | Health & social care | 2024 |
| Samantha Louise Training Academy Ltd | Other services | 2023 |
| Samerton Engineering Limited | Administrative & support | 2023 |
| Sample Inspection Limited | Energy | 2023 |
| Samraj Technologies Limited | Manufacturing | 2021 |
| Samuel Birds IT Consultancy Ltd | Information & communication | 2020 |
| SAN Fedele Ltd | Hospitality | 2022 |
| SAN the Barber Upton Ltd | Other services | 2026 |
| Sancardio Limited | Health & social care | 2019 |
| Sanclaire Property Developers Limited | Real estate | 2023 |
| Sanctum Arcana Ltd | Information & communication | 2025 |
| Sandgate Ltd | Administrative & support | 2010 |
| Sandies Solution Ltd | Health & social care | 2022 |
| Sandmere Developments Ltd | Construction | 2021 |
| Sandrock Property Management Company Limited | Households | 2003 |
| Sandside Associates Limited | Arts & recreation | 1994 |
| Sandstone Bookkeeping Ltd | Professional & scientific | 2023 |
| Sandstone House Limited | Households | 2022 |
| Sandstone Wirral Ltd | Health & social care | 2016 |
| Sani-Clad Hygienic Walls & Ceilings Limited | Construction | 2009 |
| Saniclad Biomax Ltd | Construction | 2020 |
| Sanser Ltd | Professional & scientific | 2018 |
| Sanser Medical Limited | Professional & scientific | 2013 |
| Sansiya Limited | Health & social care | 2023 |
| Santangeli Engineering Services Ltd | Professional & scientific | 2023 |
| Sapele Properties Limited | Real estate | 2018 |
| Saphire Network Services Ltd | Professional & scientific | 2018 |
| Sapill Ltd | Arts & recreation | 2015 |
| Sara Barrie & Associates Limited | Administrative & support | 2014 |
| Sara International Limited | Wholesale & retail | 2000 |
| Sarah Aesthetics Ltd | Other services | 2020 |
| Sarah Davies Consulting Ltd | Information & communication | 2014 |
| Sarah Gibson Apsa Ltd | Public administration | 2010 |
| Sarah LIN Ltd | Health & social care | 2026 |
| Sarah S Design Ltd | Arts & recreation | 2013 |
| Sardinia Delights Ltd | Transport & logistics | 2024 |
| Sarikaya Pizza Grill Ltd | Hospitality | 2022 |
| Sarrob Limited | Professional & scientific | 2018 |
| Sas-Fit Limited | Health & social care | 2012 |
| Satora Plastic Solutions Limited | Manufacturing | 2025 |
| Saunabirds Ltd | Other services | 2025 |
| Saunders (Heswall) Limited | Construction | 2014 |
| Savannah Vale Investments Ltd | Real estate | 2025 |
| Save Properties Ltd | Real estate | 2019 |
| Savour the Flavour Ltd | Extraterritorial | 2013 |
| Sawyer Manufacturing Company Ltd | Administrative & support | 1997 |
| Saxon Painting & Decorating Limited | Construction | 2022 |
| SB HR Ltd | Professional & scientific | 2025 |
| SB Window Cleaning Commercial Limited | Administrative & support | 2026 |
| SBN Legal Limited | Professional & scientific | 2023 |
| Sbwc Northwest Residential Limited | Administrative & support | 2026 |
| SC (Heswall) Ltd | Wholesale & retail | 2017 |
| SC Containers Limited | Professional & scientific | 2014 |
| Scan Trading Ltd | Professional & scientific | 2022 |
| Scanflex Limited | Manufacturing | 1990 |
| Scanlock Systems (UK) Ltd | Wholesale & retail | 2014 |
| Scarce IT Ltd | Information & communication | 2015 |
| Scartleigh Building Services Ltd | Construction | 2017 |
| Sceptre Specialist Management Services Ltd | Professional & scientific | 2023 |
| SCG Fire Safety Ltd | Professional & scientific | 2018 |
| Scholar Sports Ltd | Arts & recreation | 2025 |
| Scholars Letting Limited | Real estate | 2021 |
| School Lane (Hoylake) Management Company Limited | Households | 1994 |
| Schroeder Surveyors Ltd | Professional & scientific | 2022 |
| Scimage Ltd | Professional & scientific | 2024 |
| Scion Insurance Services Limited | Financial services | 1965 |
| Scizzor Sisters (Wirral) Limited | Other services | 2012 |
| SCJ Properties Limited | Real estate | 2012 |
| Scnw Equitrek Ltd | Transport & logistics | 2020 |
| Scoreshares Ltd | Arts & recreation | 2022 |
| Scott Williams Estates Limited | Real estate | 2024 |
| Scouse Works Limited | Real estate | 2014 |
| Scout Bar Hideout Ltd | Hospitality | 2018 |
| Scox Engineering Ltd | Professional & scientific | 2020 |
| Screen X Trade Ltd | Manufacturing | 2022 |
| Screentec Ltd | Wholesale & retail | 2020 |
| Script Shoot CUT Limited | Information & communication | 2012 |
| Sculpt Move Create Ltd | Wholesale & retail | 2024 |
| SD Properties Northwest Ltd | Real estate | 2021 |
| SDC Interpreters Limited | Professional & scientific | 2015 |
| SDF Plumbing & Heating Ltd | Construction | 2025 |
| Sdradd Ltd | Wholesale & retail | 2024 |
| SDS Lifestyle Ltd | Wholesale & retail | 2022 |
| SDS Medical Experts Limited | Administrative & support | 2010 |
| SDS Rejuvenate Limited | Other services | 2013 |
| Sea Glass Escapes Limited | Real estate | 2024 |
| Sea Thomas Marine Services Limited | Transport & logistics | 2012 |
| Seabank Marketing Ltd | Administrative & support | 2025 |
| Seabank Motorcycles Limited | Wholesale & retail | 2024 |
| Seaborg Ltd | Real estate | 2021 |
| Seacrest Subsea Services Limited | Professional & scientific | 2023 |
| Seagarth Property Limited | Real estate | 2023 |
| Seamless Travel Marketing Limited | Administrative & support | 2015 |
| Sean Counsell Architect Limited | Extraterritorial | 2025 |
| Sean Counsell Limited | Professional & scientific | 2023 |
| Sean Morley Plastering Limited | Administrative & support | 2023 |
| Searchiq Ltd | Administrative & support | 2020 |
| Seas the Day Marine Ltd | Wholesale & retail | 2017 |
| Seashanty Limited | Administrative & support | 2012 |
| Seasonal Scents Ltd | Manufacturing | 2025 |