| Rugbytots Wirral & Chester Ltd | Arts & recreation | 2024 |
| Ruhen Realtors Company Ltd | Real estate | 2023 |
| Ruleaux Ltd | Professional & scientific | 2022 |
| Ruma Climate Ltd | Manufacturing | 2025 |
| Run True Ltd | Health & social care | 2025 |
| Running Horse Investments Limited | Financial services | 2026 |
| Rurimed Ltd | Health & social care | 2024 |
| Russ Sampson Ltd | Professional & scientific | 2015 |
| Rusty Russell Ltd | Administrative & support | 2018 |
| Rutland Property Management Services Limited | Real estate | 2001 |
| Ruvalo Studios Ltd | Information & communication | 2020 |
| RV Partnership Limited | Professional & scientific | 2014 |
| RVX Investments Limited | Information & communication | 2021 |
| RWD Investments (Wirral) Limited | Real estate | 2026 |
| RWJ Engineering Ltd | Professional & scientific | 2022 |
| Rwqs Limited | Professional & scientific | 2025 |
| RXK Holdings Limited | Real estate | 2017 |
| Ryan Construction Management Ltd | Professional & scientific | 2022 |
| Rydalmere Limited | Administrative & support | 2017 |
| Ryding Care Services Limited | Health & social care | 2016 |
| RYE Court Management Company Limited | Households | 1991 |
| Rylan Associates Limited | Health & social care | 2025 |
| Réve Eyewear Ltd | Wholesale & retail | 2025 |
| S & a Enterprises Ltd | Wholesale & retail | 2019 |
| S & G Public House Limited | Hospitality | 2019 |
| S & K Plastering & Rendering Ltd | Construction | 2024 |
| S a Webster Limited | Households | 2018 |
| S B Hall Bathrooms and Wetrooms Limited | Construction | 2016 |
| S E Building Solutions Limited | Construction | 2018 |
| S Green Chef & Catering Consultant Ltd | Hospitality | 2015 |
| S J Cleaners Ltd | Administrative & support | 2016 |
| S M Dental Services Ltd | Health & social care | 2011 |
| S M Tool & Plant Hire Limited | Administrative & support | 2022 |
| S M Tool Hire | | 2000 |
| S M Tool Hire.Com Limited | Wholesale & retail | 2010 |
| S Picken Gardens Wirral Ltd | Administrative & support | 2020 |
| S R Electrical Northwest Limited | Construction | 2021 |
| S R Elliott Build & Glaze Limited | Construction | 2006 |
| S R WIN Convenience Store Ltd | Wholesale & retail | 2023 |
| S R WIN Food Ltd | Wholesale & retail | 2021 |
| S R WIN Investment Ltd | Real estate | 2025 |
| S Ravichandran Limited | Health & social care | 2014 |
| S T Oncology Limited | Health & social care | 2019 |
| S&K Osborne Limited | Transport & logistics | 2019 |
| S&K Property Projects Ltd | Real estate | 2026 |
| S&P Health Solutions Limited | Health & social care | 2024 |
| S&R Building and Construction Limited | Construction | 2022 |
| S&S Construction Ltd | Construction | 2018 |
| S&S Surgical Limited | Health & social care | 2025 |
| S. & V.E. Williams Limited | Hospitality | 1998 |
| S. M. Donally Limited | Hospitality | 1989 |
| S.E.E. the Light Wirral Limited | Real estate | 2022 |
| S.English Garden Design Ltd | Administrative & support | 2019 |
| S.H Offshore Services Limited | Manufacturing | 2025 |
| S.J Bespoke Designs Limited | Professional & scientific | 2022 |
| S.J. West Limited | Information & communication | 2012 |
| S.Janvier Limited | Health & social care | 2013 |
| S.L.L. Engineering Limited | Professional & scientific | 1999 |
| S.R.T. Motorcycles Limited | Wholesale & retail | 1980 |
| S.W.A.T. Airsoft & Paintball Ltd | Arts & recreation | 2024 |
| S.W.A.T. Airsoft Limited | Arts & recreation | 2019 |
| S.W.A.T. Shooting Range Ltd | Arts & recreation | 2025 |
| SA19 Limited | Professional & scientific | 2004 |
| Saas Consultants Ltd | Financial services | 2026 |
| Saas Scaler Limited | Professional & scientific | 2024 |
| Sabre Protection Services Limited | Administrative & support | 2022 |
| Sabre Security Systems Limited | Administrative & support | 2009 |
| SAC Engineering Design Ltd | Professional & scientific | 2022 |
| Sadia Riaz Limited | Health & social care | 2025 |
| Safe Base Care Limited | Health & social care | 2012 |
| Safe Support Services Ltd | Health & social care | 2022 |
| Safebychoice Ltd | Information & communication | 2022 |
| Safecare (Holdings) Limited | Professional & scientific | 2006 |
| Safeguard Electricians Ltd | Manufacturing | 2017 |
| Safeharbour Consulting Ltd | Information & communication | 2025 |
| Safehavenpro Limited | Professional & scientific | 2023 |
| Safelec Electrical Services Limited | Construction | 2005 |
| Safelens UK Ltd | Wholesale & retail | 2014 |
| Safer Diagnostics Ltd | Health & social care | 2025 |
| Sage Engineering Gsjj Limited | Construction | 2026 |
| SAI Convenience Shop Ltd | Wholesale & retail | 2022 |
| SAI General Store Ltd | Wholesale & retail | 2018 |
| SAJ Property Investment Limited | Real estate | 2023 |
| Sajad Bengal Ltd | Hospitality | 2024 |
| Salack Ltd | Administrative & support | 2013 |
| Salas Immigration Consulting Ltd | Professional & scientific | 2024 |
| Sale Splash Limited | Wholesale & retail | 2025 |
| Salesbow Ltd. | Wholesale & retail | 2025 |
| Salexmo Competitions Ltd | Administrative & support | 2023 |
| Salon 154 Ltd | Other services | 2014 |
| Salon Aquaflow UK Ltd | Wholesale & retail | 2020 |
| Salon Frank Inc Ltd | Other services | 2018 |
| Salon VIP Limited | Other services | 2020 |
| Salt Lake Property Investment Ltd | Real estate | 2025 |
| Salus Biotech Limited | Professional & scientific | 2025 |
| Salus Collective Ltd | Other services | 2026 |
| Salz Spice Curry Ltd | Hospitality | 2025 |
| SAM Advisers Ltd | Health & social care | 2014 |
| SAM Dessert Ltd | Hospitality | 2026 |
| SAM Sutton-Jeffs Ltd | Other services | 2025 |