| Seasoned Pioneers (Holdings) Limited | Professional & scientific | 2011 |
| Seawright Homes Ltd | Real estate | 2021 |
| SEBASTIAN247 Limited | Transport & logistics | 2014 |
| Secmed Group Ltd | Administrative & support | 2022 |
| Secretitconsulting Ltd | Information & communication | 2024 |
| Secrets Number 7 Ltd | Hospitality | 2023 |
| Secure Testing Ltd | Information & communication | 2025 |
| Security Industry Expert Ltd | Other services | 2018 |
| Security Monitoring Station Ltd | Administrative & support | 2025 |
| Securitysysteminstalls Limited | Administrative & support | 2012 |
| Sedbergh Publishing Ltd | Information & communication | 2011 |
| Sedgwictome Medical Consultancy Limited | Health & social care | 2024 |
| Seek & Roam Ltd | Information & communication | 2025 |
| Sefton Academy of TAE Kwon-Do Limited | Arts & recreation | 2020 |
| Sefton Drive Residential Management Limited | Real estate | 2006 |
| Segaisuk Limited | Arts & recreation | 2010 |
| Segal Properties Limited | Real estate | 2021 |
| Seguntolu Ltd | Health & social care | 2014 |
| Sekhar Medical Services Limited | Health & social care | 2019 |
| Selggup Ltd. | Real estate | 2017 |
| Senator Consulting Limited | Administrative & support | 2025 |
| Send IT Sports Ltd | Arts & recreation | 2025 |
| Sendac Ltd | Other services | 2023 |
| Sendegeya Medical Limited | Health & social care | 2010 |
| Sennatelyn Limited | Households | 1982 |
| Sensor Security Limited | Construction | 2006 |
| Sentra Elite Group Ltd | Administrative & support | 2026 |
| Sentry ER Ltd. | Information & communication | 2026 |
| Seren Consultancy Limited | Professional & scientific | 2004 |
| Serenity and Bliss Promotions Limited | Wholesale & retail | 2021 |
| Serenity Arts Tattoo Limited | Other services | 2022 |
| Setaria Group Limited | Manufacturing | 2017 |
| Sett Spaces Limited | Real estate | 2025 |
| Setz Hairdressing Limited | Other services | 2005 |
| Sewdark Limited | Wholesale & retail | 2024 |
| SEX ED Matters Community Interest Company | Education | 2019 |
| Sezalo Holdings Ltd | Administrative & support | 2023 |
| Sezo Investments Ltd | Real estate | 2024 |
| SF2 Holdings Limited | Financial services | 2025 |
| SFI Contracting Ltd | Construction | 2017 |
| SFL Mobile Radio Holdings Ltd | Wholesale & retail | 1997 |
| SFL Mobile Radio Ltd | Information & communication | 2020 |
| SFL Radio Bank Ltd | Information & communication | 2020 |
| SG Dermatology Ltd | Health & social care | 2019 |
| SGF Coaching Ltd | Administrative & support | 2025 |
| SGK Bros Ltd | Education | 2026 |
| SGS Properties NW Limited | Real estate | 2025 |
| SGT Property Services Limited | Construction | 2016 |
| Shack Architecture Ltd | Professional & scientific | 2011 |
| Shad Ltd | Wholesale & retail | 2019 |
| Shakespeare NW Properties Limited | Real estate | 2025 |
| Shalem Court Management Company Limited | Real estate | 2002 |
| Shamura Technologies Ltd | Information & communication | 2013 |
| Shanklygroup Ltd | Hospitality | 2022 |
| Shannon Irvine Social Consultancy Ltd | Administrative & support | 2022 |
| Shape Tech Recruitment Ltd | Administrative & support | 2023 |
| Shapingwithsophie Limited | Hospitality | 2022 |
| Sharaf & Dina Radiology Services Limited | Health & social care | 2022 |
| Sharp International UK Ltd | Extraterritorial | 2019 |
| Sharper Code Ltd | Information & communication | 2013 |
| Shashtik Local Store Limited | Wholesale & retail | 2025 |
| Shashtik Properties Ltd | Real estate | 2025 |
| Shaun Marnell Ltd | Wholesale & retail | 2003 |
| Shaun Stone Consultancy Ltd | Professional & scientific | 2015 |
| Sheena Carroll HR Solutions Ltd | Administrative & support | 2013 |
| Sheer Horizon Ltd | Financial services | 2019 |
| Sheernest Properties Limited | Real estate | 2025 |
| SHELTER4YOU Ltd | Financial services | 2023 |
| Shena Jena Limited | Real estate | 2024 |
| Sheng XI Ltd | Hospitality | 2026 |
| Shenstone Homes (D & B) Limited | Construction | 2010 |
| Shepha Properties Limited | Real estate | 2018 |
| Sherrillian Consultants Ltd | Professional & scientific | 2022 |
| Sheryl Curran Ltd | Professional & scientific | 2016 |
| Sheryl Ltd | Real estate | 2023 |
| Sheryl Stays Ltd | Real estate | 2024 |
| Shetland Ecology Limited | Professional & scientific | 2021 |
| Shibah Property Development Limited | Real estate | 2017 |
| Shining River Investments Ltd | Real estate | 2024 |
| Shiny Wood Limited | Manufacturing | 2018 |
| Shoes Reunited Ltd | Construction | 2011 |
| Shone Properties Ltd | Households | 2025 |
| Shootin Boots Limited | Arts & recreation | 2014 |
| Shop Cameo Ltd | Wholesale & retail | 2018 |
| Shop Honu Ltd | Wholesale & retail | 2018 |
| Shore Fit Kitchens & Bathrooms Limited | Construction | 2024 |
| Short Term Digs Ltd | Real estate | 2024 |
| Shost Ltd | Other services | 2017 |
| Shoulder Success Ltd | Education | 2023 |
| Show & SET Solutions Limited | Information & communication | 2020 |
| Shri Siddaroodha Ltd | Health & social care | 2022 |
| Shrub END Diner Ltd | Hospitality | 2025 |
| Siaeo Limited | Real estate | 2025 |
| Siako Car Wash Ltd | Administrative & support | 2024 |
| Siam Heswall Ltd | Other services | 2023 |
| Siamgreasby Limited | Hospitality | 2011 |
| Sid's Barber Wirral Ltd | Other services | 2023 |
| Sidhupharm Limited | Financial services | 2011 |
| Siekar Properties Limited | Real estate | 2017 |
| Sienna Maya Ltd | Real estate | 2020 |