| Digitalmarketinglib Ltd | Wholesale & retail | 2025 |
| Digpro Ltd | Construction | 2018 |
| Digpro NW Ltd | Construction | 2025 |
| Dilek Dessert Ltd | Hospitality | 2024 |
| Dimensions Reprographics Limited | Manufacturing | 1988 |
| Dimpu Limited | Extraterritorial | 2004 |
| Dinas Rock Limited | Administrative & support | 2015 |
| Dining With Darek Ltd | Hospitality | 2026 |
| Dinning and Duckett Estates Limited | Real estate | 2018 |
| Dinorwic Projects Ltd | Real estate | 2021 |
| Dinos Pizzeria Wirral Ltd | Hospitality | 2026 |
| Direct Tyres NW Ltd | Wholesale & retail | 2016 |
| Dirtyrides Apparel Ltd | Wholesale & retail | 2025 |
| Disc Electrical (Nantwich) Limited | Construction | 2012 |
| Discount Mobile Phones Limited | Wholesale & retail | 2022 |
| Discover Games UK Ltd | Wholesale & retail | 2025 |
| Discover PVM Limited | Professional & scientific | 2022 |
| Dispoosables Ltd | Wholesale & retail | 2023 |
| Distant Horizons Homes Ltd | Hospitality | 2017 |
| Distant Horizons Ltd. | Administrative & support | 1996 |
| Diverse Active C.I.C. | Arts & recreation | 2015 |
| Diverse Sports Hub Ltd | Education | 2021 |
| Dixie Holdings Limited | Construction | 2025 |
| Dixon Strategic Group Limited | Professional & scientific | 2026 |
| Diydiscowirral Ltd | Administrative & support | 2023 |
| DJM Insulation Ltd | Construction | 2023 |
| DJM Marine Limited | Transport & logistics | 2026 |
| Djmt Investments Ltd | Administrative & support | 2025 |
| DJR HSE Solutions Ltd | Professional & scientific | 2025 |
| DKJ Consulting Limited | Professional & scientific | 2025 |
| DKL Property Solutions Ltd | Construction | 2020 |
| DKM Coachworks Ltd | Wholesale & retail | 2025 |
| DKS Solutions Limited | Wholesale & retail | 2007 |
| DL Air-Con Services Ltd | Construction | 2020 |
| DLC Food Hub Limited | Hospitality | 2025 |
| DLH Consultancy Services Ltd | Professional & scientific | 2008 |
| DLH Property Lettings Limited | Hospitality | 2019 |
| DLR Jewellers Ltd | Wholesale & retail | 2025 |
| Dmbengineeringservices Ltd | Professional & scientific | 2022 |
| DMD Brickwork Ltd | Construction | 2019 |
| DMK Consultancy Limited | Construction | 2015 |
| Dmroo Ltd | Construction | 2025 |
| DMS (Wirral) Ltd | Professional & scientific | 2013 |
| DMS Developments (NW) Ltd | Construction | 2022 |
| DMW FIN Serv Ltd | Financial services | 2023 |
| DND Engineering Ltd | Professional & scientific | 2021 |
| DNG Properties Limited | Real estate | 2006 |
| Dobson Optical Consultancy Limited | Health & social care | 2018 |
| DOCTOR4U Ltd | Health & social care | 2021 |
| Doctored Ltd | Professional & scientific | 2022 |
| Doctus 2001 Limited | Extraterritorial | 2001 |
| Document Direct Limited | Administrative & support | 2005 |
| Dodd and Partners Limited | Professional & scientific | 2017 |
| Dodwells of Wirral Ltd | Manufacturing | 2018 |
| Dofins Limited | Hospitality | 2013 |
| Doggit Builders Limited | Administrative & support | 1975 |
| Dolly Coffey Holdings Ltd | Professional & scientific | 2015 |
| Dolphin Automotive Limited | Wholesale & retail | 2016 |
| Dome Bulle UK Ltd | Wholesale & retail | 2023 |
| Dominique Faversham (Commercial) LLP | | 2006 |
| Dominiux Ltd | Information & communication | 2024 |
| Domissoundco Ltd. | Information & communication | 2018 |
| Donegan & Curtis Autos Limited | Wholesale & retail | 2025 |
| Door and Window Systems Limited | Manufacturing | 2020 |
| Doorstep Estates Ltd | Real estate | 2025 |
| Dotty's Desserts Ltd | Wholesale & retail | 2023 |
| Double Boxed Toys Ltd | Wholesale & retail | 2018 |
| Double Clap Limited | Information & communication | 2014 |
| Dough & Flame Ltd | Hospitality | 2026 |
| Dough-Hut Ltd | Hospitality | 2022 |
| Dove Holland Property Ltd | Real estate | 2024 |
| Dovedale Court (Garrick Avenue) Management Limited | Real estate | 2004 |
| Dovepoint Developments Ltd | Real estate | 2003 |
| Dovepoint Education Ltd | Education | 2024 |
| Downham Road Management Company Limited | Households | 2000 |
| Downmac Electrical Limited | Construction | 2019 |
| DP Industries Ltd | Wholesale & retail | 2023 |
| DP Property 2 Limited | Real estate | 2020 |
| DP Property 3 Limited | Real estate | 2020 |
| DP Property 4 Limited | Real estate | 2020 |
| DP Sloan Ltd | Wholesale & retail | 2025 |
| DPB Care Consultancy Ltd | Education | 2025 |
| DPL FAB Limited | Manufacturing | 2013 |
| DPL Fabrications Limited | Construction | 2002 |
| DPL Property Investment Group Ltd | Real estate | 2023 |
| DPL Structural Steel Limited | Professional & scientific | 2015 |
| Dpre Investments Ltd | Real estate | 2025 |
| DPT Products 2U Ltd | Wholesale & retail | 2024 |
| DR D and DR a Gupta Limited | Households | 2017 |
| DR Khushal Morar Limited | Health & social care | 2019 |
| DR Khushbu Morar Limited | Health & social care | 2025 |
| DR Maren Health Ltd | Administrative & support | 2025 |
| DR Rachel Sinton Ltd | Health & social care | 2023 |
| DR Richard Azurdia Ltd | Health & social care | 2012 |
| DR Rose Ltd | Health & social care | 2009 |
| DR Russell Austin Paediatric Services Limited | Health & social care | 2015 |
| DR Silvester and Associates Ltd | Professional & scientific | 2025 |
| Draco Bakery Limited | Wholesale & retail | 2025 |
| Dragon Data Recovery Ltd | Information & communication | 2019 |
| Dragonfly Couture Stationery Limited | Manufacturing | 2009 |