| Dragonfly PM Ltd | Information & communication | 2025 |
| Dragonvi Ltd | Wholesale & retail | 2024 |
| Drain Brains Ltd | Water & waste | 2013 |
| Dream Accountancy Limited | Administrative & support | 2019 |
| Dreams Solutions Ltd | Construction | 2021 |
| Dreamspace Bedrooms Ltd | Manufacturing | 2024 |
| Drifty Riskness Ltd | Arts & recreation | 2016 |
| Dring Maritime Services Limited | Transport & logistics | 2012 |
| Drinkwater Solutions Limited | Information & communication | 2017 |
| Driving School Academy Limited | Education | 2022 |
| DRM TM Ltd | Construction | 2018 |
| DRN Enterprise Limited | Wholesale & retail | 2024 |
| Dropzone Demolition Limited | Construction | 2011 |
| DRT Trading Limited | Professional & scientific | 2025 |
| Drummond RD Property Management Ltd | Real estate | 2017 |
| DRY Cleaning by David Ltd | Other services | 2026 |
| DS Financial Services Ltd | Professional & scientific | 2017 |
| Ds&I Limited | Financial services | 2024 |
| DSH Energy Ltd | Construction | 2020 |
| DSR Music Management Ltd | Arts & recreation | 2015 |
| DT & G Limited | Manufacturing | 2002 |
| DTA (Wirral) Limited | Professional & scientific | 2019 |
| DTN Trading Ltd | Professional & scientific | 2024 |
| DTR Marketing Ltd | Administrative & support | 2019 |
| Dual Protection Ltd | Administrative & support | 2025 |
| Ducky's Design Ltd | Administrative & support | 2020 |
| Duff Electrics Ltd | Construction | 2006 |
| Dun-Bar Hybrid Scaffolds Limited | Other services | 2021 |
| Dunamis Computer Systems Limited | Information & communication | 1991 |
| Dunedin Court Management Company Limited | Real estate | 2001 |
| Dunlec Electrical Ltd | Construction | 2026 |
| Dunnyman Engineering Services Ltd | Professional & scientific | 2025 |
| Dunraven Road (West Kirby) Management Limited | Households | 2013 |
| Dunsandles BED & Breakfast Ltd | Administrative & support | 2016 |
| Durlstone Properties Ltd | Real estate | 2025 |
| Dust Angels 2 LLP | | 2018 |
| Duxier Tax Recruitment Ltd | Administrative & support | 2026 |
| DV Contracting Ltd | Administrative & support | 2023 |
| DVD Copying Direct Ltd | Administrative & support | 2009 |
| DW Builders NW Ltd | Construction | 2026 |
| DW Building Contractors (North West) Limited | Construction | 2019 |
| Dwcivils Limited | Construction | 2025 |
| Dwell Well Properties Ltd | Real estate | 2025 |
| DWH Joinery & Building Limited | Construction | 2022 |
| DWJ Travel & Airport Transfers Ltd | Transport & logistics | 2023 |
| Dwjl Ltd | Wholesale & retail | 2018 |
| DX3 Limited | Hospitality | 2021 |
| Dynamic Balancing Northwest Ltd | Professional & scientific | 2012 |
| Dynamic Hydro Limited | Extraterritorial | 2022 |
| Dynamic Plumbing Wirral Ltd | Construction | 2022 |
| Düdar Ltd | Extraterritorial | 2021 |
| E and K Property Limited | Real estate | 2019 |
| E S Therapies Ltd | Health & social care | 2025 |
| E&A Properties NW Limited | Real estate | 2025 |
| E&K Conway Ltd | Real estate | 2020 |
| E&P Resin Floors Limited | Construction | 2023 |
| E-Ject Plugs Ltd | Manufacturing | 2019 |
| E-Motion Consulting Limited | Information & communication | 2009 |
| E-Van Leasing Limited | Wholesale & retail | 2011 |
| E. B. Design & Build Limited | Real estate | 1996 |
| E.A. Reed & Sons Limited | Agriculture & fishing | 1986 |
| E.F.Beddard & Co.Limited | Real estate | 1935 |
| E.J.O.R. Investments Limited | Real estate | 2025 |
| EA Capabilities Limited | Information & communication | 2012 |
| EA Mech Limited | Professional & scientific | 2018 |
| EAD Property Limited | Real estate | 2019 |
| EAR Care Solutions Limited | Health & social care | 2026 |
| Earlam & Partners (Property) Ltd | Real estate | 2018 |
| Earlam and Jobling Investment Company Ltd | Professional & scientific | 2021 |
| Earlam and Partners (EAP) Limited | Information & communication | 2010 |
| Earlsway Property Solutions Limited | Professional & scientific | 2014 |
| Earth Cycle Action Limited | Water & waste | 2014 |
| Earth Florists Limited | Administrative & support | 2017 |
| Earth Observation Ltd | Agriculture & fishing | 2015 |
| Eastham Angling Centre Ltd | Wholesale & retail | 2017 |
| Eastham Community Centre Ltd. | Hospitality | 2012 |
| Eastham Dental Practice Limited | Health & social care | 2011 |
| Eastham Estates Limited | Extraterritorial | 2016 |
| Eastham Garden Centre Ltd | Wholesale & retail | 2022 |
| Eastham Hall Wellness Centre Limited | Health & social care | 2024 |
| Eastham Motors Limited | Wholesale & retail | 2018 |
| Eastham Pizza Ltd | Hospitality | 2026 |
| Eastham Village Developments Shared Access Limited | Administrative & support | 2018 |
| Eastwood & Sharples Limited | Manufacturing | 1949 |
| Easy House Plus Limited | Real estate | 2021 |
| Easy Living NW Ltd | Real estate | 2022 |
| Easy Spares & Repairs Ltd | Other services | 2012 |
| EASY2MOVE (NW) Ltd | Transport & logistics | 2018 |
| Easybigwins Limited | Administrative & support | 2024 |
| Easystaycrewe Ltd | Hospitality | 2025 |
| Easytech Solutions Ltd | Administrative & support | 2010 |
| Easywalk Ltd | Transport & logistics | 2015 |
| Eaton Developments (North West) Limited | Administrative & support | 2003 |
| Eav's OFF Licence Ltd | Wholesale & retail | 2025 |
| EBH Properties Limited | Real estate | 2026 |
| EBM Executive Protection Ltd | Administrative & support | 2026 |
| Eboda Limited | Financial services | 2007 |
| EC Bookkeeping Solutions Ltd | Professional & scientific | 2024 |
| ECA Group Ltd | Financial services | 2020 |
| Echelon Eyewear Limited | Administrative & support | 2021 |