| Scenn Ltd | Manufacturing | 2019 |
| SCF Hardware Ltd. | Wholesale & retail | 1999 |
| SCG Management Consulting Limited | Professional & scientific | 2023 |
| Schematek Limited | Information & communication | 2022 |
| Schneider Prototyping (UK) Limited | Professional & scientific | 2009 |
| Scott Miles Roofing Ltd | Construction | 2014 |
| Scout&Hunter Ltd | Hospitality | 2020 |
| Scratch Architecture Limited | Professional & scientific | 2021 |
| Scratch Heroes Ltd | Wholesale & retail | 2022 |
| Scribble Solutions Limited | Professional & scientific | 2001 |
| SCS Maintenance Ltd | Construction | 2021 |
| SCW Retail LLP | | 2025 |
| SD IT Contract Services Limited | Professional & scientific | 2024 |
| SDA Music Services Limited | Professional & scientific | 2020 |
| SDB Digital Ltd | Information & communication | 2020 |
| SDF Services Ltd | Other services | 2018 |
| Sea Breeze Building Services Ltd | Construction | 2015 |
| Sea Fishing (Poole) Limited | Transport & logistics | 1965 |
| Sea to Sky Innovations Limited | Professional & scientific | 2020 |
| Seabrook Lewis Limited | Professional & scientific | 2020 |
| Sean Hills Design Ltd | Information & communication | 2016 |
| Sean Mckenna Consultancy Limited | Information & communication | 2023 |
| Search & Employ Limited | Professional & scientific | 2017 |
| Searchlight IT Solutions Limited | Information & communication | 2010 |
| Searchlight Surveyors Ltd | Professional & scientific | 2020 |
| Seaview Pubs Ltd | Hospitality | 2024 |
| SEB Aerospace Limited | Professional & scientific | 2014 |
| SEC IT Solutions Ltd | Information & communication | 2000 |
| Second Nature Consulting Limited | Professional & scientific | 2022 |
| Secure Pathway Consulting Ltd | Information & communication | 2026 |
| Securewithdenzo Ltd | Information & communication | 2025 |
| Sedona Design and Development Ltd | Real estate | 1972 |
| Seed to Summit Community Interest Company | Arts & recreation | 2024 |
| Seeking Solutions Ltd | Professional & scientific | 2019 |
| Seeoursocials Ltd | Professional & scientific | 2026 |
| Seet Consulting Ltd | Professional & scientific | 2017 |
| Segga Services Ltd | Professional & scientific | 2024 |
| SEH - HR Consulting Limited | Administrative & support | 2014 |
| Sehmi Property Investments Limited | Real estate | 2020 |
| Seiche Software Limited | Information & communication | 2021 |
| Seigur Limited | Information & communication | 2016 |
| Select Catering Consultancy Limited | Hospitality | 2023 |
| Seller Republic Limited | Information & communication | 2015 |
| Sellerly Limited | Administrative & support | 2017 |
| Selma Motors Ltd | Wholesale & retail | 2026 |
| Semantic Partners Ltd | Information & communication | 2021 |
| Seotagg Limited | Information & communication | 2023 |
| Seproco Ltd | Information & communication | 2012 |
| Serenity Bedrooms and Interiors Ltd | Manufacturing | 2013 |
| Sereno Therapy Ltd | Health & social care | 2019 |
| Service DE Velo Ltd | Wholesale & retail | 2018 |
| Services Will Vary Ltd | Professional & scientific | 2024 |
| Serviseek Ltd | Information & communication | 2025 |
| SET 2 LET (Dorset) Limited | Real estate | 2011 |
| Seven Ventures Tech Ltd | Information & communication | 2026 |
| Seventec Limited | Manufacturing | 2021 |
| Sewn UP Ltd | Professional & scientific | 2026 |
| Seybrook Limited | Real estate | 2010 |
| Seymour Management Company (Ringwood) Limited | Households | 2004 |
| Seyward Window Co. Limited | Manufacturing | 1996 |
| Sezamee Ltd | Information & communication | 2016 |
| SF Technic Ltd | Wholesale & retail | 2017 |
| Sfava Consulting Services Limited | Information & communication | 2022 |
| SG Accounting Ltd | Extraterritorial | 2022 |
| SG Construction Ltd | Construction | 2016 |
| SG Contractor Accounting Limited | Professional & scientific | 2015 |
| SG Umbrella Limited | Professional & scientific | 2016 |
| Shabba Ltd | Wholesale & retail | 2026 |
| Shadow Concepts Ltd | Information & communication | 2021 |
| Shaftesbury Drove Management Limited | Households | 2018 |
| Shamrock House Ltd | Information & communication | 2016 |
| Shamwari Project Management Limited | Professional & scientific | 2010 |
| Shanduko Rwendo Ltd | Professional & scientific | 2022 |
| Shape Conservation Limited | Construction | 2024 |
| Sharon K Ltd | Administrative & support | 2023 |
| Sharp BTL Limited | Construction | 2020 |
| Sharp Carpentry Limited | Construction | 2017 |
| Sharp Content Communications Ltd | Professional & scientific | 2019 |
| Sharp Investments Limited | Other services | 2020 |
| Sharpn Ltd | Professional & scientific | 2020 |
| Shaw ICT Consulting Ltd | Professional & scientific | 2016 |
| Shawarby Bayanova Limited | Information & communication | 2025 |
| Shears Brothers Limited | Real estate | 1961 |
| Sheclips Hair Salon Limited | Other services | 2003 |
| Sheephouse Healthcare Consulting Limited | Professional & scientific | 2018 |
| Shelford Computing Ltd | Information & communication | 2014 |
| Shepherd Court (Brimsmore) Management Limited | Households | 2020 |
| Shepherd Solutions Limited | Information & communication | 2025 |
| Sherine Arafa Ltd | Professional & scientific | 2018 |
| Sherriff Heritage Double Glazing Ltd | Manufacturing | 2023 |
| Sherriff Logistics Ltd | Transport & logistics | 2026 |
| Sherriff Stained Glass Limited | Manufacturing | 2022 |
| Shewt Limited | Professional & scientific | 2006 |
| Shibumi Yacht Charters Limited | Other services | 2024 |
| Shibumi Yachts Limited | Other services | 2014 |
| Shield Engineering Ltd | Information & communication | 2019 |
| Shifting Sands Ltd | Professional & scientific | 2024 |
| Shiny Hardware Limited | Wholesale & retail | 2005 |
| Shires Wealth Management Ltd | Financial services | 2016 |
| Shirley Thompson Limited | Professional & scientific | 2005 |