| Shiva Shetty Consulting Ltd | Information & communication | 2026 |
| SHK IT Solutions Ltd | Information & communication | 2022 |
| SHL Manufacturing Limited | Manufacturing | 2013 |
| Shoestring Budget Limited | Information & communication | 2025 |
| Shore & Shire Leisure Ltd | Hospitality | 2022 |
| Shoreline Commercial Limited | Administrative & support | 2021 |
| Shoreline Homes Limited | Real estate | 1998 |
| Shoretech Group UK Limited | Wholesale & retail | 2015 |
| Shortwave UK Ltd. | Manufacturing | 2006 |
| Shrc (Site Handling Repairs & Construction) Ltd | Construction | 1998 |
| Shrc (Steve Hillier Racing Company) Ltd | Wholesale & retail | 2024 |
| SI Mcmahon Marketing Consultancy Limited | Professional & scientific | 2024 |
| Sibley Inns Ltd | Hospitality | 2026 |
| Sibuga Properties Limited | Real estate | 2023 |
| Side Letter Limited | Professional & scientific | 2026 |
| SIDE8 Ltd | Information & communication | 2020 |
| Sidney Street Consulting Limited | Professional & scientific | 2024 |
| Siesta Frames Limited | Manufacturing | 2003 |
| Signs & Display Ltd | Manufacturing | 2018 |
| Silent Edge Ltd | Administrative & support | 2026 |
| Silhillian Consulting Limited | Information & communication | 2015 |
| Silicon Guru Ltd | Information & communication | 2017 |
| Silver Beech Consulting Ltd | Information & communication | 2016 |
| Silver Bullet Technologies Limited | Information & communication | 2025 |
| Silver Rose Developments Ltd | Financial services | 2024 |
| Silver Space Limited | Information & communication | 2017 |
| Silver Wheels Limited | Manufacturing | 2012 |
| Silverglades Investments Limited | Real estate | 1994 |
| Silvermouse Limited | Information & communication | 2017 |
| Silverroute Ltd | Transport & logistics | 2026 |
| SIM One Consultancy Ltd | Information & communication | 2015 |
| Simba Projects Ltd | Professional & scientific | 2018 |
| Simon J. Richards Ltd | Information & communication | 2017 |
| Simon Peacock Ltd | Professional & scientific | 2012 |
| Simonini Properties Ltd | Construction | 2022 |
| Simpat Innovations Ltd | Education | 2023 |
| Simpkin HC Holdings Limited | Real estate | 2023 |
| Simpkin Property Holdings Limited | Real estate | 2019 |
| Simpkin Property Limited | Real estate | 2024 |
| Simple Coffee Company Ltd | Extraterritorial | 2024 |
| Simple Telecommunications Limited | Information & communication | 2012 |
| Simple Zero Consulting Limited | Information & communication | 2018 |
| Simplebi Investments Ltd | Financial services | 2021 |
| Simpli-Fi Cloud Ltd | Information & communication | 2026 |
| Simpli-Fi.It Ltd | Construction | 2019 |
| Simpliance Consulting Limited | Professional & scientific | 2020 |
| Simplicial Ltd | Information & communication | 2021 |
| Simply Landscaping Ltd | Administrative & support | 2011 |
| Simply Mint Media Ltd | Professional & scientific | 2020 |
| Simply Scentsational Limited | Manufacturing | 2013 |
| Simulator Centre Services Ltd | Administrative & support | 2014 |
| Sinearc Limited | Administrative & support | 2013 |
| Sinfield Associates Ltd | Professional & scientific | 2010 |
| Singularit Limited | Information & communication | 2019 |
| Sinthujon Investment Properties Limited | Real estate | 2021 |
| Sion Tech Consultancy Services Limited | Information & communication | 2022 |
| Sirius Car Design Limited | Wholesale & retail | 2021 |
| Sissy Enterprises Ltd | Real estate | 2023 |
| Sista Management LLP | | 2023 |
| Siyakat Networks Limited | Information & communication | 2025 |
| Sizzle Studios Limited | Other services | 2020 |
| SJA Installations Ltd | Manufacturing | 2016 |
| SJB IT Services Limited | Information & communication | 2020 |
| SJH Professional Services Ltd | Professional & scientific | 2024 |
| Sjmc Consultants Limited | Professional & scientific | 2021 |
| Sjrad Consulting Limited | Information & communication | 2024 |
| Sjsc Engineering Services Limited | Professional & scientific | 2014 |
| SK Films Ltd | Information & communication | 2015 |
| SK Property Group Ltd | Real estate | 2015 |
| Skan IT Solutions Limited | Information & communication | 2012 |
| Skec Limited | Administrative & support | 2010 |
| Skhealth Holdings Ltd | Financial services | 2025 |
| Skin ID Limited | Health & social care | 2018 |
| Skin Infinity Aesthetics Ltd | Health & social care | 2022 |
| Skinny Hippo Ltd | Wholesale & retail | 2018 |
| Skrypt Costumes Limited | Administrative & support | 2021 |
| Skyhill Group Ltd | Information & communication | 2023 |
| Skylight DEV Ltd | Information & communication | 2021 |
| Skyline NJC Property Ltd | Construction | 2024 |
| Skytrux Limited | Transport & logistics | 2014 |
| Slade UN Limited | Professional & scientific | 2022 |
| Sleepingenius Creative Enterprises Ltd | Information & communication | 2023 |
| Sleepwalker Studios Ltd | Information & communication | 2022 |
| Slidesafe Limited | Construction | 2025 |
| Slik Consulting Ltd | Information & communication | 2023 |
| Slingsby Digital Limited | Professional & scientific | 2026 |
| Small Engineering Limited | Manufacturing | 2002 |
| Small Vans Direct Limited | Wholesale & retail | 2024 |
| Smalls Yard Management Limited | Real estate | 2014 |
| Smart Resurface Ltd | Other services | 2022 |
| Smart Septic Ltd | Construction | 2025 |
| Smart Wash Wimborne Ltd | Administrative & support | 2022 |
| SMB Network Solutions Ltd | Information & communication | 2005 |
| SMH Lean Leadership Consulting Limited | Professional & scientific | 2025 |
| Smile Events & Media Ltd | Professional & scientific | 2011 |
| Smiles and Solutions Limited | Professional & scientific | 2026 |
| Smith Apps Limited | Information & communication | 2020 |
| Smith Properties Solutions Ltd | Real estate | 2026 |
| Smokey Joe's Catering Ltd | Hospitality | 2022 |
| Smrm Consulting Limited | Information & communication | 2020 |