| Site Management & Supervision UK Ltd | Manufacturing | 2014 |
| SJ Brickwork Limited | Construction | 2008 |
| SJC Plumbing and Heating NW Ltd | Construction | 2019 |
| SJJ Contracts Limited | Construction | 2019 |
| SJJ Enterprise Limited | Financial services | 2021 |
| SJJ Property Group Limited | Construction | 2021 |
| SJM Plumbing & Heating Ltd | Construction | 2020 |
| SJN Quess Services Limited | Professional & scientific | 2014 |
| Skepre Care Ltd | Health & social care | 2025 |
| Sketch! Comics Limited | Information & communication | 2026 |
| Skillsage Ltd | Information & communication | 2024 |
| Skin Visions Limited | Administrative & support | 2020 |
| Skippy Skip Hire (NW) Ltd | Water & waste | 2022 |
| SKR Developments Ltd | Real estate | 2021 |
| Sky Shield Roofing Ltd | Construction | 2026 |
| Skyline Property (NW) Limited | Real estate | 2025 |
| SLA Lettings Ltd | Real estate | 2024 |
| Slater Avionics Limited | Professional & scientific | 2025 |
| Slatra Ltd | Transport & logistics | 2020 |
| Sleeptight Beds (Widnes) Ltd | Wholesale & retail | 2011 |
| Slipway Burscough Limited | Real estate | 2017 |
| SLK Civils Limited | Construction | 2026 |
| SMA Productions Limited | Information & communication | 2023 |
| Smart Plant and Tool Hire Limited | Administrative & support | 2024 |
| Smartify Trading Limited | Wholesale & retail | 2026 |
| SMB Interiors Ltd | Professional & scientific | 2016 |
| Smith Asset Management Ltd | Real estate | 2025 |
| Smith Property NW Ltd | Real estate | 2024 |
| SMJ Homes Limited | Real estate | 2026 |
| Smw&Sons Limited | Transport & logistics | 2026 |
| Snap VI Ltd | Professional & scientific | 2025 |
| Snig PIE House Limited | Hospitality | 2017 |
| Soap Stores Ltd | Wholesale & retail | 2025 |
| Soapbox Trading Ltd | Other services | 2018 |
| Softplay Planet Limited | Other services | 2020 |
| Sojay Ltd | Health & social care | 2014 |
| Solarmanuk Ltd | Wholesale & retail | 2025 |
| Solas Energy Solutions Ltd | Construction | 2025 |
| Solen Energy Group Limited | Professional & scientific | 2012 |
| Solen Energy UK Limited | Manufacturing | 2011 |
| Solid Furnished Solutions Ltd | Real estate | 2025 |
| Solution Transport Limited | Transport & logistics | 2004 |
| Solutions Through Sport Ltd | Professional & scientific | 2018 |
| Solve Creative Ltd | Arts & recreation | 2022 |
| Sondanik Limited | Health & social care | 2023 |
| Sonhar Padel Ltd | Arts & recreation | 2025 |
| Sophisticutz (NW) Limited | Other services | 2016 |
| Soprano 91 Limited | Transport & logistics | 2017 |
| Sorin Haulage Ltd | Transport & logistics | 2015 |
| Sorted Energy Limited | Construction | 2023 |
| South Island K9 Security and Dog Training Ltd | Administrative & support | 2025 |
| South Lane Plant Hire Limited | Wholesale & retail | 1989 |
| Southport Spa Ltd | Health & social care | 2026 |
| Spa Deck Ltd | Construction | 2025 |
| Space Ninja Technologies Ltd | Information & communication | 2024 |
| Spaflo Ltd | Manufacturing | 2019 |
| Sparkbook Media Ltd | Wholesale & retail | 2012 |
| Spartner Limited | Other services | 2016 |
| Specialist Driver Provider Limited | Transport & logistics | 2013 |
| SPF Automation Limited | Real estate | 2012 |
| SPI Training Limited | Arts & recreation | 2020 |
| Spice Kitchen Online Limited | Manufacturing | 2016 |
| Spice of Bangal Ltd | Hospitality | 2023 |
| Spike Island Cafe Widnes Ltd | Hospitality | 2026 |
| Sport Events Global Ltd | Transport & logistics | 2018 |
| Sporting Events (Liverpool) Limited | Administrative & support | 2005 |
| Sporting Events Global Limited | Administrative & support | 2001 |
| Sporting NW Developments Limited | Construction | 2019 |
| Sports Travel Liverpool Ltd | Administrative & support | 2017 |
| Sportsorg PM Limited | Administrative & support | 2016 |
| SPR Developments Ltd | Real estate | 2017 |
| Sprakes & Sons Limited | Wholesale & retail | 2012 |
| Springharbour Limited | Professional & scientific | 2010 |
| Square Deal Properties Ltd | Real estate | 2022 |
| SR Painters Ltd | Construction | 2024 |
| SR Reinforcement and Formwork Limited | Construction | 2017 |
| Srdj Ltd | Hospitality | 2024 |
| SRT Builders Ltd | Construction | 2025 |
| Ssaat Ltd | Wholesale & retail | 2023 |
| SSD Property Group Ltd | Real estate | 2026 |
| SSG Scaffolding Ltd | Construction | 2018 |
| ST George's Holdings Limited | Financial services | 2019 |
| ST Paul's Orthodontics Limited | Health & social care | 2019 |
| ST Raphael's Orthodontics Limited | Health & social care | 2018 |
| ST. Helens Mobility Shop Limited | Wholesale & retail | 2004 |
| ST. Helens Site Holdings Limited | Professional & scientific | 2018 |
| Stable Drive CIC | Education | 2025 |
| Stable House Properties Ltd | Real estate | 2020 |
| Stackweb Ltd | Professional & scientific | 2025 |
| Stanton's of Cheshire Limited | Wholesale & retail | 2009 |
| Star Advertising Ltd | Professional & scientific | 2026 |
| Stay Sharpe NW Limited | Manufacturing | 2023 |
| Stead and Mercer Ltd | Other services | 2014 |
| Stead and Mercer Properties Ltd | Real estate | 2025 |
| Steam Hammer Ltd | Information & communication | 2024 |
| Step Stones Property Ltd | Construction | 2022 |
| Step to the Stage Costumes Ltd | Wholesale & retail | 2021 |
| Stepgin Ltd | Construction | 2024 |
| Stephen J Tabner Limited | Transport & logistics | 2002 |
| Steve Taylor Construction Ltd | Construction | 2012 |