| S J K Technology Limited | Professional & scientific | 2008 |
| S J Prescott Transport Limited | Transport & logistics | 2002 |
| S K Bourke Ltd | Health & social care | 2017 |
| S Pyke Limited | Information & communication | 2002 |
| S R Brickwork NW Limited | Construction | 2025 |
| S Tech Communications Ltd | Construction | 2022 |
| S&E Brightmart Ltd | Hospitality | 2026 |
| S&G Marketing Limited | Professional & scientific | 2017 |
| S&J Group Ltd | Hospitality | 2019 |
| S-Tek Projects Limited | Administrative & support | 2018 |
| S. Blythin Holding Ltd | Construction | 2023 |
| S.A.Prentice Limited | Professional & scientific | 2012 |
| S.M.B Investment Group Limited | Financial services | 2023 |
| Sacha Grace Hair Solutions Limited | Health & social care | 2016 |
| Safe Harbour Publishing Ltd | Information & communication | 2026 |
| Safety Outlet Ltd | Manufacturing | 2019 |
| Safety Software Consultants Limited | Information & communication | 2019 |
| Safis WID Ltd | Hospitality | 2025 |
| Sahathiri Stone Limited | Wholesale & retail | 2025 |
| Salisbury Property Partners Ltd | Real estate | 2023 |
| Salon One Limited | Other services | 2014 |
| SAN Marino Italian Foods Limited | Hospitality | 2020 |
| SAN Marino Mediterranean Restaurant Ltd | Hospitality | 2018 |
| Sandos Kabab House Ltd | Hospitality | 2026 |
| Sandy Lane Farm Limited | Hospitality | 2017 |
| Saphire Combustion Ltd | Manufacturing | 2012 |
| Sarah Cosmetics Ltd | Other services | 2025 |
| Saran & Deals Ltd | Transport & logistics | 2020 |
| Saspas Ltd | Construction | 2019 |
| Sata Properties Ltd | Real estate | 2024 |
| Satnaam Properties Limited | Real estate | 2017 |
| Savage Media Solutions Limited | Professional & scientific | 2024 |
| Sawasdee Thai Restaurant Ltd | Hospitality | 2026 |
| SB Construction NW Ltd | Construction | 2025 |
| SC & D Ltd | Administrative & support | 2019 |
| SC Trans Dimy Ltd | Transport & logistics | 2019 |
| Scallywags (Liverpool) Ltd | Wholesale & retail | 2021 |
| Schenk UK Holding Ltd | Financial services | 2022 |
| Schenk UK Ltd | Transport & logistics | 1988 |
| Schneider Lift Controls Ltd. | Wholesale & retail | 2017 |
| SCJ Property Management Ltd | Real estate | 2025 |
| Scorpion Mouse Engineering Ltd | Manufacturing | 2015 |
| Scottfab Limited | Construction | 2004 |
| Scrivens Technology Limited | Administrative & support | 2021 |
| Scuba Junkies Ltd | Education | 2026 |
| Sculpt and Align Limited | Arts & recreation | 2017 |
| SD Wise Techs Limited | Information & communication | 2017 |
| SDS Reinforcement Ltd | Construction | 2019 |
| Second Story Recovery CIC | Health & social care | 2026 |
| Sector 7 Electrical Services Limited | Construction | 2017 |
| Sefton Park (Liverpool) Management Company Limited | Households | 2004 |
| Select Cheshire Limited | Administrative & support | 2018 |
| Sell Smart Property Limited | Households | 2025 |
| Seller Circle Ltd | Information & communication | 2022 |
| Send R US CIC | Administrative & support | 2022 |
| Sentari Labs Ltd | Information & communication | 2024 |
| Sentio Psychotherapy Practice Ltd | Health & social care | 2020 |
| Seras Energy Ltd | Administrative & support | 2009 |
| Serenity Stationery & Creations Ltd | Manufacturing | 2023 |
| Serenity Wellbeing House Limited | Health & social care | 2024 |
| Servispart Limited | Professional & scientific | 2006 |
| Seven Bathrooms Ltd | Construction | 2026 |
| SFN Holdings Ltd | Wholesale & retail | 2026 |
| SGH 1969 Limited | Administrative & support | 2015 |
| SGI Inc Ltd | Construction | 2023 |
| Shafi Collections Ltd | Wholesale & retail | 2023 |
| Shardfin Consulting Ltd | Professional & scientific | 2023 |
| Shariful & Co Ltd | Wholesale & retail | 2025 |
| Sharow Property Services Ltd | Real estate | 2005 |
| Shaw Consult Limited | Construction | 2021 |
| Shawbuild Construction Ltd | Construction | 2022 |
| Shazna Takeaway Limited | Hospitality | 2016 |
| Shecommerce Ltd | Education | 2024 |
| Shelby Construction Ltd | Construction | 2018 |
| Shenstone Validation Services Limited | Professional & scientific | 2016 |
| Sheps Herd Limited | Construction | 2024 |
| SHG (NW) Limited | Hospitality | 2019 |
| Shining Star Care Awards Ltd | Administrative & support | 2025 |
| Shipley Property Solutions Limited | Real estate | 2025 |
| Shoreside Psychology Limited | Health & social care | 2023 |
| Shorties Studios Ltd | Information & communication | 2026 |
| Sienka Ltd | Real estate | 2017 |
| Sigiriya Restaurants Ltd | Hospitality | 2006 |
| Sigmarho Consulting Limited | Professional & scientific | 2019 |
| Signature Home Improvements (Warrington) Ltd | Construction | 2023 |
| Signature Memorial Imports UK Limited | Manufacturing | 2025 |
| Silk Architecture Ltd | Professional & scientific | 2019 |
| Silknest Apparel Ltd | Manufacturing | 2026 |
| Silky Bouquets Ltd | Wholesale & retail | 2011 |
| Sillery AI Limited | Wholesale & retail | 2016 |
| Siloam Christian Ministries Limited | Health & social care | 1987 |
| Silverline Properties (NW) Limited | Real estate | 2006 |
| Silvestru Ltd | Transport & logistics | 2018 |
| Simms Cross PUB Ltd | Hospitality | 2022 |
| Simple Vend Ltd | Wholesale & retail | 2024 |
| Simply Fencing Ltd | Wholesale & retail | 2024 |
| SINS1 Ltd | Hospitality | 2026 |
| Sirbu Logistics Ltd | Transport & logistics | 2018 |
| Sirikonda Medical Services Ltd | Health & social care | 2019 |
| Sisterella Limited | Wholesale & retail | 2024 |