| Stevenson Family Holdings Ltd | Financial services | 2025 |
| Stonefields Homes Limited | Construction | 2020 |
| Stonehartrent Ltd | Financial services | 2022 |
| Stones Gym Widnes Ltd | Other services | 2019 |
| Stonewallgroupfs Ltd | Construction | 2026 |
| Stoneycroft Trading Ltd | Wholesale & retail | 2013 |
| Stows Enterprise Ltd | Administrative & support | 2018 |
| STR Training 01 Limited | Wholesale & retail | 2024 |
| STR Training 02 Limited | Wholesale & retail | 2024 |
| STR Training 03 Limited | Wholesale & retail | 2026 |
| Stratiq Contract Solutions Limited | Professional & scientific | 2025 |
| Strongstar Limited | Information & communication | 2014 |
| Studio 33 Tattoos Limited | Other services | 2019 |
| Studio Crema Ltd | Extraterritorial | 2022 |
| Studio M Pilates Ltd | Arts & recreation | 2025 |
| Stukershaw Ltd | Arts & recreation | 2019 |
| Style Hair Cut(Widnes) Ltd | Other services | 2018 |
| Substance Digital Ltd | Information & communication | 2025 |
| Success Accident Solutions Limited | Professional & scientific | 2003 |
| Succession Consultancy Ltd | Professional & scientific | 2024 |
| Summer's Daughter Ltd | Wholesale & retail | 2021 |
| Sunflower Embroidery Ltd | Manufacturing | 2023 |
| Sunnydee Clean Limited | Other services | 2025 |
| Sunyata Handicrafts Ltd | Wholesale & retail | 2021 |
| Superior Catering Limited | Hospitality | 2013 |
| Superior Delivery Limited | Financial services | 2020 |
| Superior Portfolio Limited | Real estate | 2019 |
| Support After Sport | Administrative & support | 2024 |
| Support at Home Ltd | Administrative & support | 2011 |
| Support at Home Properties Ltd | Real estate | 2024 |
| Supreme X Ltd | Transport & logistics | 2022 |
| Suran Barber Ltd | Other services | 2023 |
| Sure Safe Electrics (Widnes) Limited | Construction | 2011 |
| Sure Safe Properties Limited | Real estate | 2018 |
| Surepay Merchant Services Ltd | Administrative & support | 2016 |
| Surerent Investments Ltd | Real estate | 2025 |
| Surezone Plastering Ltd | Construction | 2026 |
| Sushi on the Go Limited | Hospitality | 2024 |
| Suspended Sessions Ltd | Financial services | 2025 |
| Sutton Plumbing and Heating Ltd | Construction | 2021 |
| Suttons International Holdings Limited | Financial services | 2022 |
| Sutty Limited | Real estate | 2005 |
| Svkm Properties Limited | Real estate | 2026 |
| Swan Hvac Limited | Construction | 2024 |
| SWE IT Ltd | Information & communication | 2025 |
| Sweet ME UP Ltd | Wholesale & retail | 2026 |
| Swift Electrical NW Ltd | Construction | 2023 |
| Swinkee Properties Ltd | Real estate | 2024 |
| Sword Technical & Engineering Limited | Professional & scientific | 2017 |
| SWS Contracting Ltd | Construction | 2022 |
| SWS M&E Ltd | Professional & scientific | 2020 |
| SWS Northwest Ltd | Construction | 2017 |
| SWS NW Holding Limited | Financial services | 2022 |
| Syers Investments Ltd | Real estate | 2024 |
| Symes Club Systems Limited | Information & communication | 2017 |
| System Integration Specialists Ltd | Professional & scientific | 2022 |
| T D Motors Limited | Wholesale & retail | 2014 |
| T M M Catering Ltd | Hospitality | 2026 |
| T O Properties Limited | Administrative & support | 2000 |
| T&A Mechanical Services Ltd | Professional & scientific | 2020 |
| T. Hannah Engineering Services Ltd | Professional & scientific | 2023 |
| T.Lucas & Son(Liverpool)Limited | Construction | 1947 |
| T1 Together Ltd | Administrative & support | 2021 |
| T4 Property Group Ltd | Real estate | 2025 |
| Tacit Management Limited | Professional & scientific | 2012 |
| Tailorhaus Developments Limited | Real estate | 2025 |
| Takebon Limited | Hospitality | 2025 |
| Tamanegi Collective Ltd | Information & communication | 2024 |
| Tanhouse Tyre and Exhaust Limited | Wholesale & retail | 1993 |
| Tanpit Fold Management Company Ltd | Households | 2021 |
| Tarmilliam Ltd | Professional & scientific | 2022 |
| Tasq Ltd | Professional & scientific | 2020 |
| Tasq Properties Ltd | Real estate | 2025 |
| Tasteology Ltd | Manufacturing | 2026 |
| Taylor & Aigburth Developments Ltd | Real estate | 2024 |
| Taylor Sparks Properties Limited | Real estate | 2024 |
| Tcuthbert Engineering Services Limited | Professional & scientific | 2019 |
| TD Property Renovations Ltd | Construction | 2019 |
| Team Montage UK Ltd | Construction | 2022 |
| Tech Lifecycles Limited | Information & communication | 2010 |
| Tech Network Cabling Ltd | Construction | 2020 |
| Tech Telecom Ltd | Wholesale & retail | 2019 |
| Tech Weld Engineering Ltd | Construction | 2019 |
| Technidata UK Limited | Administrative & support | 2002 |
| Technik Weld Limited | Construction | 2002 |
| Tekgun Limited | Construction | 2023 |
| TEO Trans Ltd | Transport & logistics | 2025 |
| Tepló LAB Ltd | Manufacturing | 2025 |
| Termelian Global Recruitment Limited | Hospitality | 2026 |
| Teron Enterprises Limited | Wholesale & retail | 1997 |
| Terry's Fish Bar Ltd | Hospitality | 2016 |
| Terry’S Rentals Ltd | Real estate | 2021 |
| Terumi Limited | Other services | 2026 |
| Tery Geox Ltd | Transport & logistics | 2018 |
| TFW Filling Services Ltd | Manufacturing | 2025 |
| TGC Mechanical Services (UK) Ltd | Manufacturing | 2004 |
| TGS Wholesale Ltd | Wholesale & retail | 2025 |
| TH Property Solutions Ltd | Real estate | 2019 |
| That BIT Healthier Limited | Wholesale & retail | 2025 |
| THE Academy Cafe Ltd | Hospitality | 2025 |