| Double Hero Trade Ltd | Manufacturing | 2024 |
| Dovis International Trading Co., Limited | Manufacturing | 2023 |
| DPM Construction Midlands 1 Ltd | Construction | 2024 |
| Dpt-Fam Contractors Ltd | Construction | 2023 |
| Driving Wheel Records Ltd | Information & communication | 1998 |
| Droach Travel Limited | Transport & logistics | 2005 |
| DRS Welding Services Limited | Construction | 1999 |
| Dryfix Installations Limited | Construction | 2021 |
| Drywall Pro-Cut Limited | Construction | 2019 |
| Dsat Properties Ltd. | Real estate | 2007 |
| DSI Underground UK Limited | Mining & quarrying | 2001 |
| Dsun Trading Limited | Wholesale & retail | 2024 |
| Dubstarz Limited | Construction | 2006 |
| Dudley Body Repairs Ltd | Wholesale & retail | 2026 |
| Dudley Lodge | Health & social care | 1999 |
| Dudley Road Builders and Plumbers Merchants Ltd | Wholesale & retail | 2002 |
| Duggan Transport Ltd | Transport & logistics | 2000 |
| Dunns Imaging Group Limited | Professional & scientific | 1958 |
| Duport C.W. Limited | | 1919 |
| Duport L.W.S. Limited | | 1932 |
| Duraframe Systems Limited | Extraterritorial | 1985 |
| Duright Engineering Limited | Manufacturing | 2003 |
| Dutch Shell London Technology Limited | Mining & quarrying | 2023 |
| DVS Group Co., Ltd. | Extraterritorial | 2023 |
| DW Carpentry Limited | Construction | 2001 |
| E & M Limited | Professional & scientific | 1977 |
| E F R Limited | Financial services | 2004 |
| E G Kebabs Ltd | Wholesale & retail | 2019 |
| E Hammond Case & Pallet Limited | Manufacturing | 1995 |
| E Murataj Construction Ltd | Construction | 2023 |
| E S Wright & SON Limited | Administrative & support | 1987 |
| E-Accounting Solutions Limited | Professional & scientific | 2003 |
| E-Let Properties Ltd | Real estate | 2002 |
| E. Hulme & SON Limited | Manufacturing | 2003 |
| E.A. Denny Limited | Hospitality | 1984 |
| E.C. Electrical Services Limited | Construction | 2003 |
| E.W. Carr Limited | Administrative & support | 2005 |
| Eagle Windows Limited | Construction | 2017 |
| Ease Your Step Chiropody Limited | Health & social care | 2006 |
| East Anglian Galvanizing Limited | Manufacturing | 1969 |
| Eastworth Enterprises Limited | Construction | 1997 |
| Eaveswood Limited | Administrative & support | 1982 |
| EBC European Business Centre Limited | Administrative & support | 2004 |
| Eccles (UK Foundries FE) Limited | Manufacturing | 1992 |
| Eccleston & Hart Limited | Manufacturing | 1959 |
| Eddowes Perry and Osbourne Limited | Professional & scientific | 2008 |
| Edge IT Solutions Limited | Information & communication | 2006 |
| Edmar Engineering Co. Limited | Manufacturing | 1945 |
| Edmond Catering Limited | Hospitality | 2024 |
| Ednam Investments Limited | Real estate | 1999 |
| Edward Evans Car and Commercial Limited | Transport & logistics | 1961 |
| Edward Gray of Dudley Limited | Manufacturing | 1951 |
| Edward Howell Galvanizers Limited | Manufacturing | 1935 |
| Edwards Accountants (Midlands) Limited | Professional & scientific | 2004 |
| Edwards Accounting Services Limited | Professional & scientific | 2004 |
| Edwards Business Services Limited | Professional & scientific | 2004 |
| Edwards Business Solutions Limited | Professional & scientific | 2004 |
| Edwards Plastic Fabrications Limited | Manufacturing | 1998 |
| Edwin Blakemore and Co Limited | Professional & scientific | 1999 |
| Effective Dispute Solutions Limited | Professional & scientific | 2006 |
| Efoam.Co.Uk.Limited | Manufacturing | 2005 |
| Egaming Media Ltd | Wholesale & retail | 1999 |
| EI Group Limited | Hospitality | 1990 |
| EI Tenanted Properties Limited | Hospitality | 2025 |
| Eiger Developments (Graingers Lane) Limited | Construction | 2006 |
| Eileen Mason Photography Limited | Professional & scientific | 2002 |
| Ekeeta Limited | Health & social care | 2024 |
| EL ROI Transport and Warehousing Ltd | Transport & logistics | 2020 |
| Electric Bicycle Innovation Limited | Manufacturing | 2023 |
| Electric Centre Limited | Wholesale & retail | 1994 |
| Electronic Properties Limited | Professional & scientific | 2006 |
| Elegance Enterprise Ltd | Transport & logistics | 2004 |
| Element MAN Limited | Administrative & support | 2006 |
| Eleven Stars Limited | Information & communication | 2026 |
| Elford BIO Fuels Limited | Manufacturing | 2006 |
| Elford Plant Hire Limited | Construction | 1995 |
| Elimpic Limited | Water & waste | 1982 |
| Elite Associates (Services) Limited | Information & communication | 1997 |
| Elite Digital Solutions Ltd | Wholesale & retail | 2007 |
| Elite Fabrication (Midlands) Limited | Construction | 2001 |
| Elite Property Management Limited | Real estate | 1999 |
| Elite Radio Cars Limited | Transport & logistics | 2001 |
| Elite Trading Limited | Wholesale & retail | 2002 |
| Elliott Management Services Limited | Professional & scientific | 2006 |
| Ellmanton Construction Company Limited | Real estate | 1963 |
| Elmdon Office Supplies Limited | Wholesale & retail | 1976 |
| Elmhurst Ballet School Trust | Education | 1994 |
| Elmhurst Enterprises Limited | Real estate | 2002 |
| Elta Automotive Ltd | Wholesale & retail | 1993 |
| Embley Limited | Construction | 1984 |
| EME Nike & Co Ltd | Health & social care | 2014 |
| Employment Law Services (UK) Limited | Administrative & support | 2002 |
| Emunah Promotions Ltd | Professional & scientific | 2021 |
| Endurance Steels Limited | Real estate | 2002 |
| Energy & Power Limited | Energy | 2025 |
| Energy Ratings Limited | Professional & scientific | 2007 |
| Enfex Limited | Extraterritorial | 1999 |
| Engineered Timber Solutions Limited | Manufacturing | 2003 |
| Engineering Services (FR) Limited | Wholesale & retail | 2005 |
| Engineering Services Consultancy Limited | Professional & scientific | 2002 |