| D COX & Co Limited | Professional & scientific | 2002 |
| D Robinson Electrical Services Limited | Construction | 2003 |
| D S L Motor Repairs Ltd | Wholesale & retail | 2003 |
| D. J. & C. Macinnes & Sons Limited | Construction | 2006 |
| D. Lander Limited | Construction | 2006 |
| D. R. Bannocks Group Limited | Financial services | 1973 |
| D.A.S. (Land Investment Cheslyn HAY) Limited | Real estate | 1974 |
| D.Cairns Building & Maintenance Limited | Construction | 2000 |
| D.G.W. Roofing & Cladding Limited | Construction | 2005 |
| D.H. Scriven Electrical Limited | Construction | 1987 |
| D.J.H. Technology Limited | Information & communication | 2003 |
| D.K. Double Glazing Limited | Manufacturing | 2006 |
| D.M.S. Protective Equipment Limited | Administrative & support | 2005 |
| D.N. Engineering Suppliers Ltd | Wholesale & retail | 2006 |
| D.P. Design (UK) Limited | Professional & scientific | 1996 |
| D.S. Willetts (Stainless) Limited | Manufacturing | 1984 |
| D.V. Contracts Limited | Information & communication | 2003 |
| D318 Limited | Manufacturing | 1988 |
| D5 Architects LLP | | 2005 |
| D5 Property Limited | Real estate | 2002 |
| DAE Holdings Ltd | Financial services | 2020 |
| DAE Residential Limited | Real estate | 2020 |
| Daffodils Nursery Ltd. | Health & social care | 2014 |
| Daicykiran Limited | Professional & scientific | 2012 |
| Daisy Bank Books Limited | Wholesale & retail | 2007 |
| Dalasoft Limited | Information & communication | 1995 |
| Dalen Limited | Manufacturing | 1981 |
| Daleswood Limited | Hospitality | 1996 |
| Dalkeith Limited | Professional & scientific | 1987 |
| Daly Heating Contractors Limited | Financial services | 2007 |
| Damson Builders Limited | Construction | 2000 |
| Daniel Batham & SON Limited | Manufacturing | 1942 |
| Daniels Electrical Services (West Midlands) Limited | Construction | 2000 |
| Dantrad Limited | Real estate | 1986 |
| Darcast Components (2000) Limited | Professional & scientific | 1915 |
| Darlaston Town FC Limited | Arts & recreation | 2023 |
| Darui Co., Ltd | Manufacturing | 2023 |
| Data Developments (UK) Limited | Information & communication | 2003 |
| Data Security Systems Limited | Administrative & support | 1998 |
| Datadepth Limited | Wholesale & retail | 1990 |
| Datechnology Limited | Information & communication | 2004 |
| David Allport Limited | Construction | 1994 |
| David Austin Rose Nursery Limited | Extraterritorial | 2003 |
| David Fabb (Manufacturing) Limited | Professional & scientific | 2000 |
| Davis & Samuels Limited | Health & social care | 1952 |
| Davis Cooling Services Ltd | Construction | 2007 |
| Davis Memorials Limited | Other services | 2004 |
| Davixus Consulting Limited | Professional & scientific | 2024 |
| Dawson Bros.(Timber)Limited | Manufacturing | 1961 |
| Daxmo Limited | Wholesale & retail | 1995 |
| Day to Day Shop Private Limited | Wholesale & retail | 2026 |
| DB Foam & Fibre Limited | Manufacturing | 2020 |
| DCN Bearings and Engineering Ltd | Manufacturing | 2001 |
| Dean Harper Funeral Directors & Stonemasons Limited | Other services | 2000 |
| Dean Standley Properties Limited | Real estate | 2022 |
| Decorative Windows Limited | Construction | 2006 |
| Deeley Construction Limited | Construction | 1948 |
| Deeley Group Limited | Professional & scientific | 1977 |
| Deeley Homes Limited | Construction | 1938 |
| Deeley Properties Limited | Construction | 1962 |
| Deepblue Recordings (UK) Limited | Information & communication | 1999 |
| Deerpha (UK) Chemical Industry Limited | Manufacturing | 2023 |
| Delija Properties Limited | Real estate | 2023 |
| Delta G.B.N. Limited | Administrative & support | 1984 |
| Delta International Holding Limited | Administrative & support | 2004 |
| Delta Processes Ltd | Construction | 2012 |
| Denmark Basda International Holdings Co., Ltd | Wholesale & retail | 2023 |
| Densol Limited | Manufacturing | 2002 |
| Dependable Springs & Pressings Limited | Manufacturing | 1937 |
| Derek Cooke Financial Limited | Financial services | 2005 |
| Design Syntax Limited | Professional & scientific | 2004 |
| Designer Building Services Limited | Professional & scientific | 2002 |
| Detector Distribution Limited | Wholesale & retail | 2005 |
| Devante Devz Reid Ltd | Arts & recreation | 2024 |
| Dhaliwal Homes Ltd | Real estate | 2018 |
| Dhesi Investment Limited | Real estate | 2003 |
| Diagu Ltd | Information & communication | 2022 |
| Diamensions Limited | Manufacturing | 2005 |
| Diamond Construction (Coventry) Limited | Construction | 2002 |
| Diamond Nails Spa & Beauty Ltd | Other services | 2022 |
| Dick Fisher.Com Limited | Professional & scientific | 2004 |
| Dickens EYE Clinic Limited | Wholesale & retail | 2006 |
| Diehl GTS Limited | Other services | 2007 |
| Digitalx Technology Limited | Information & communication | 2023 |
| Dilectrics Limited | Construction | 2006 |
| Dimminsdale Properties Limited | Administrative & support | 2009 |
| Dinglong International Tobacco Co., Ltd | Manufacturing | 2024 |
| Dingsheng Co., Limited | Wholesale & retail | 2023 |
| Direeza Limited | Manufacturing | 2023 |
| Dismantling & Engineering Limited | Wholesale & retail | 1950 |
| Distance Learning Limited | Education | 1989 |
| DJ Upholstery Limited | Construction | 2007 |
| DJH Builders Limited | Construction | 2011 |
| DJH Halesowen Limited | Professional & scientific | 1998 |
| Doherty Earthmovers Limited | Extraterritorial | 2001 |
| Doorcare Limited | Manufacturing | 2002 |
| Dopica Ltd | Transport & logistics | 2020 |
| Dormer Pramet Limited | Manufacturing | 1947 |
| Dosanj Promotions Limited | Professional & scientific | 2003 |
| Dosh Limited | Health & social care | 2007 |