| Sikavella Limited | Wholesale & retail | 2026 |
| Sikh Education Forum | Education | 2021 |
| SIL Enterprises Limited | Manufacturing | 2009 |
| Silicon-Micro Limited | Real estate | 2000 |
| Silverton Midlands Ltd | Construction | 2026 |
| Silverton Transport Ltd | Transport & logistics | 2016 |
| Silverwood Estate UK. Ltd | Real estate | 2021 |
| SIMEGAT47 Limited | Wholesale & retail | 2025 |
| Simfluence Ltd | Wholesale & retail | 2020 |
| Simone Singh Limited | Hospitality | 2023 |
| Simran Transport Ltd | Transport & logistics | 2023 |
| Sinclair & Co Limited | Professional & scientific | 2011 |
| Singh Beans UK Ltd | Hospitality | 2020 |
| Singh Coffee Machines UK Ltd | Wholesale & retail | 2022 |
| Singh Concrete Pumps Ltd | Construction | 2023 |
| Singh Sahib Transport Ltd | Transport & logistics | 2015 |
| Singhs Events & Decor Ltd | Hospitality | 2017 |
| Singhs Haulage Ltd | Transport & logistics | 2013 |
| Singhs Tyre Service Ltd | Wholesale & retail | 2025 |
| Sital Transport Ltd | Transport & logistics | 2019 |
| Site Products Limited | Wholesale & retail | 2016 |
| Siwula Company Ltd | Real estate | 2025 |
| SJ Commercial Export Limited | Wholesale & retail | 2018 |
| SJD Builder Ltd | Construction | 2019 |
| Sjr-Training Ltd | Education | 2024 |
| Sjrbars Ltd | Hospitality | 2024 |
| SK Investors Ltd | Real estate | 2024 |
| SK Paper Company Limited | Wholesale & retail | 2018 |
| SK Property Midlands Ltd | Real estate | 2021 |
| SK Security Ltd | Administrative & support | 2025 |
| SK2 Couriers Ltd | Transport & logistics | 2026 |
| Skarphu Ltd | Information & communication | 2025 |
| SKB Law Ltd | Professional & scientific | 2011 |
| SKD Advisory Limited | Professional & scientific | 2026 |
| Skilife Limited | Wholesale & retail | 2021 |
| Skilled Training and Recruitment Specialists Ltd | Administrative & support | 2025 |
| Skills Training and Recruitment Specialists CIC | Administrative & support | 2024 |
| SKJ Home Improvements Limited | Construction | 2025 |
| SKJ Property Ltd | Households | 2024 |
| SKK Haulage Ltd | Transport & logistics | 2024 |
| Skmp Services Limited | Construction | 2024 |
| Skrp Limited | Real estate | 2019 |
| SKS (Sian) Ltd | Real estate | 2016 |
| SKW 79 Ltd | Hospitality | 2023 |
| Skwv Trading Limited | Construction | 2025 |
| Skyblue Bristol Ltd | Professional & scientific | 2021 |
| Skyview Glass Ltd | Construction | 2026 |
| Skywalka Sky's the Limit STL Ltd | Administrative & support | 2019 |
| SL Civil Engineering Ltd | Construction | 2026 |
| SL Skyline Construction Limited | Construction | 2018 |
| Slatch Auto Clinic Ltd | Wholesale & retail | 2021 |
| Slessor Healthcare Staffing Ltd | Administrative & support | 2022 |
| Sloughtyres Ltd | Wholesale & retail | 2018 |
| SM Midland Properties Ltd | Real estate | 2021 |
| SMA (Accountants) Limited | Professional & scientific | 2014 |
| SMA Associates Ltd | Professional & scientific | 2014 |
| SMA Capital Limited | Financial services | 2018 |
| Smart Skills Driving School Limited | Education | 2025 |
| Smart Wirework Ltd | Construction | 2025 |
| Smart Wrench Auto Garage Ltd | Wholesale & retail | 2025 |
| Smartshoppe Ltd | Wholesale & retail | 2024 |
| Smash Desserts Limited | Hospitality | 2023 |
| Smashed Inc Ltd | Hospitality | 2021 |
| Smashin' Repairs Ltd | Wholesale & retail | 2016 |
| SME Web Solutions Limited | Information & communication | 2017 |
| Smethwick Maintenance Company Limited | Professional & scientific | 1958 |
| Smile Confident Limited | Health & social care | 2023 |
| Smith and Janes Midlands Limited | Construction | 2018 |
| Smithy Property Ltd | Real estate | 2025 |
| Smooth Skin and Laser Clinic Limited | Other services | 2018 |
| Smslubana Ltd | Transport & logistics | 2025 |
| SN Portfolios Ltd | Real estate | 2023 |
| Soba Transport Limited | Transport & logistics | 2024 |
| Sodi Transport Ltd | Transport & logistics | 2020 |
| Sofa Solutions (UK) Ltd | Wholesale & retail | 2015 |
| Sohail Ahmed Ltd | Construction | 2025 |
| Sohal Accountancy Limited | Professional & scientific | 2023 |
| Sokhl Limited | Hospitality | 2018 |
| Sol&Care CIC | Health & social care | 2025 |
| Solair Building Products Limited | Manufacturing | 1996 |
| Solar Electrical Security Ltd | Manufacturing | 2023 |
| Solek Digital Ltd | Information & communication | 2025 |
| Sollaman Consultancy Services Ltd | Professional & scientific | 2010 |
| Soltidevimukunda Ltd | Hospitality | 2022 |
| Solution Estates Ltd | Real estate | 2023 |
| Solutions 360 Car Ltd | Wholesale & retail | 2025 |
| Sona Properties & Investments Limited | Real estate | 2023 |
| Sonadesk Ltd | Information & communication | 2026 |
| Sonique Dresses Limited | Wholesale & retail | 2019 |
| Soothecare Ltd | Health & social care | 2021 |
| Sorel Transport Ltd | Transport & logistics | 2013 |
| SOS 24 Hours Limited | Construction | 2018 |
| SOS Hire Limited | Wholesale & retail | 2025 |
| South West Entertainment Ltd | Hospitality | 2025 |
| SOW Bar Ltd | Hospitality | 2024 |
| SOW Kitchen Limited | Wholesale & retail | 2021 |
| Sparkes Supplies Limited | Wholesale & retail | 2000 |
| Specialist Joinery Products Limited | Construction | 1999 |
| Specialty Gases Limited | Extraterritorial | 1971 |
| Speed Courier Services Ltd | Transport & logistics | 2025 |