| SCMT4 Ltd | Real estate | 2025 |
| SCP Home Improvements Ltd | Construction | 2023 |
| SCP Total Clean Solutions Limited | Administrative & support | 2025 |
| Scpcleaningserviceslimited Ltd. | Administrative & support | 2021 |
| Scrap Metal Recyclers Ltd | Wholesale & retail | 2024 |
| SD Precision Parts Ltd | Wholesale & retail | 2023 |
| SE Window Glazing Limited | Construction | 2025 |
| Seatbelt Specialist Limited | Wholesale & retail | 2022 |
| Second FIX Electrix Ltd | Wholesale & retail | 2025 |
| Second Life Bags Ltd | Wholesale & retail | 2025 |
| Secret Opulence Ltd | Wholesale & retail | 2026 |
| Secret Velvet Limited | Wholesale & retail | 2026 |
| Section 34 Ltd | Wholesale & retail | 2025 |
| Secural Security Limited | Other services | 2018 |
| Secure Line Electrical Ltd | Construction | 2023 |
| Secure Send Courier Ltd | Transport & logistics | 2025 |
| Secure-Guard Security Services Limited | Administrative & support | 2020 |
| Security and Homeworks Limited | Construction | 2013 |
| Sega International Limited | Wholesale & retail | 2019 |
| Sehbaaz Transport Ltd | Transport & logistics | 2025 |
| Sehgal Transport Limited | Transport & logistics | 2025 |
| Select Lifestyles Limited | Health & social care | 2007 |
| Select Lifestyles Services Limited | Health & social care | 2021 |
| Selected Security Ltd | Wholesale & retail | 2025 |
| Semijoe Limited | Real estate | 2021 |
| Semper Maior Limited | Information & communication | 2024 |
| Semplice Restaurant Ltd | Hospitality | 2025 |
| Sentinel Vehicle Solutions Limited | Extraterritorial | 2011 |
| Serendipity Estates Limited | Real estate | 2024 |
| Serene Investments Limited | Real estate | 2021 |
| Service Republic Ltd. | Other services | 2012 |
| Serviceconnect Ltd | Construction | 2025 |
| Services NG Ltd | Wholesale & retail | 2022 |
| Seven Hills Hospitality Ltd | Hospitality | 2022 |
| Seven Seas Group Ltd | Wholesale & retail | 2023 |
| Seven Star Barbers Limited | Other services | 2020 |
| SEW & SO Coventry Ltd | Wholesale & retail | 2022 |
| Sfhls Ltd | Administrative & support | 2026 |
| SGI Transport Ltd | Transport & logistics | 2018 |
| Sgph Ltd | Construction | 2026 |
| SGS (West Bromwich) Limited | Administrative & support | 2011 |
| SH Bar and Grill Limited | Hospitality | 2024 |
| SH Trans Ltd | Transport & logistics | 2014 |
| Shaftesbury Casino Holdings Limited | Financial services | 2016 |
| Shaftesbury Casino Limited | Arts & recreation | 2016 |
| Shaibi Property Ltd | Real estate | 2024 |
| Shake and Stir Cocktail Limited | Hospitality | 2025 |
| Shalgani Limited | Health & social care | 2025 |
| Shalimar Bagh Ltd | Real estate | 2018 |
| Shamim Lettings Ltd | Real estate | 2026 |
| Shamsher Autos Ltd | Wholesale & retail | 2026 |
| Shamsher Haulage Ltd | Transport & logistics | 2016 |
| Sharma Transport Ltd | Transport & logistics | 2026 |
| Shaun Hodgetts Ltd | Transport & logistics | 2013 |
| Shauns Autos Limited | Wholesale & retail | 2025 |
| Shawarma (Midlands) Ltd | Hospitality | 2024 |
| Shawarma (UK) Ltd | Hospitality | 2026 |
| Shaykkudo Limited | Wholesale & retail | 2021 |
| Sheilordon Gun-Dachs Limited | Other services | 2021 |
| Sheldon Clayton Asset Management Limited | Professional & scientific | 1978 |
| Sheldon Clayton Holdings Limited | Professional & scientific | 2009 |
| Sheldon Clayton Logistics Limited | Transport & logistics | 1996 |
| Sheldon Clayton Properties Limited | Construction | 2021 |
| Shem Transport Ltd | Transport & logistics | 2024 |
| Sheraa Ltd | Transport & logistics | 2022 |
| Sherwood Truck and Van Ltd | Wholesale & retail | 1984 |
| Shingai Care Limited | Health & social care | 2022 |
| Shirzad Catering Ltd | Hospitality | 2026 |
| Shiv Gardens 2K22 Ltd | Health & social care | 2022 |
| Shiv Gardens UK 2020 Ltd | Health & social care | 2020 |
| Shiv Shakti Developments Limited | Construction | 2013 |
| Shivanya Transport Ltd | Transport & logistics | 2026 |
| Shivasai Corporation Ltd | Wholesale & retail | 2012 |
| Shivay Catering Ltd | Hospitality | 2023 |
| Shivay Indian Sweets Ltd | Wholesale & retail | 2023 |
| Shivay Properties Limited | Real estate | 2021 |
| SHK Construction Limited | Administrative & support | 2012 |
| Shko Ltd | Other services | 2023 |
| Shmitz Limited | Construction | 2023 |
| Shoplifyy Ltd | Wholesale & retail | 2025 |
| Shopperzutopia Limited | Wholesale & retail | 2024 |
| Shree Bhoj Kitchen Ltd | Hospitality | 2025 |
| Shri Mateshwari Foods Ltd | Hospitality | 2025 |
| Shriya Fabrics Ltd | Wholesale & retail | 2022 |
| Shriya Fabrics Online Ltd | Wholesale & retail | 2024 |
| Shubh Tech One Limited | Construction | 2026 |
| Shubhra Properties Limited | Real estate | 2022 |
| Shuhej Ltd | Wholesale & retail | 2025 |
| Si-Tech Machine Tool Services Ltd | Manufacturing | 2023 |
| SIA Couriers Ltd | Transport & logistics | 2025 |
| Sias Finance Ltd | Construction | 2020 |
| Sica Transport Ltd | Transport & logistics | 2025 |
| Siddhartha Properties Limited | Real estate | 2025 |
| Siddhika Limited | Hospitality | 2021 |
| Siddons Alloy Castings Ltd. | Extraterritorial | 1988 |
| Sidhu Constructions (WM) Ltd | Construction | 2025 |
| Sidhu Courier Midland Ltd | Transport & logistics | 2025 |
| Sienna Medical Consultancy Ltd | Health & social care | 2025 |
| Signature Hardware Limited | Other services | 2002 |
| Signature Transport -UK Ltd | Transport & logistics | 2023 |