| Spice Fuzion Ltd | Hospitality | 2020 |
| Spindry Mid's Ltd | Other services | 2025 |
| Spinney Grill House Ltd | Hospitality | 2024 |
| Spire Creative Products Limited | Wholesale & retail | 1998 |
| Spire Homewares Limited | Professional & scientific | 1883 |
| Spire Manufacturing Holdings Limited | Financial services | 2025 |
| Spon Auto Repairs Ltd | Wholesale & retail | 2020 |
| Spon Lane Chippy Ltd. | Hospitality | 2019 |
| Spon Lane Day Nursery Limited | Education | 2016 |
| Spon Lane MOT & Service Centre Ltd | Wholesale & retail | 2026 |
| Sporting Spirit CIC | Arts & recreation | 2015 |
| Sports 4 Kids Ltd | Arts & recreation | 2014 |
| Sports Sector Limited | Wholesale & retail | 2019 |
| Sportsmans Club West Bromwich Limited | Hospitality | 2013 |
| Spotless Property Maintenance Ltd | Construction | 2023 |
| Spotty Dog Bars Ltd | Hospitality | 2022 |
| Spotty Dog Events Ltd | Arts & recreation | 2022 |
| SPS Global Partners Ltd | Administrative & support | 2025 |
| SRA Verma Limited | Information & communication | 2015 |
| Srhwilnwa L Ltd | Wholesale & retail | 2025 |
| SRT Carwash Co Ltd | Administrative & support | 2023 |
| SRT Logistics Limited | Transport & logistics | 2025 |
| SRT Products Ltd | Wholesale & retail | 2022 |
| SS Line Ltd | Transport & logistics | 2019 |
| SS Portfolios Ltd | Real estate | 2021 |
| SS Transport B,Ham Ltd | Transport & logistics | 2023 |
| Ssak Dhindsa Construction Ltd | Construction | 2026 |
| SSG Transport Ltd | Transport & logistics | 2026 |
| SSJ Property Services Ltd | Real estate | 2019 |
| Ssjk Properties Limited | Real estate | 2025 |
| SSK Builders Midlands Ltd | Construction | 2024 |
| SSK Singh Builders Ltd | Construction | 2020 |
| Ssmdj Holdings Ltd | Financial services | 2020 |
| SSN Civils Ltd | Construction | 2020 |
| Sspd Consultants Ltd | Professional & scientific | 2015 |
| SSR Transport Ltd | Wholesale & retail | 2026 |
| SSS Supply Ltd | Transport & logistics | 2026 |
| SSS Trading Investment Ltd | Real estate | 2024 |
| SSS Trading Transport Ltd | Transport & logistics | 2020 |
| SSS Transport Ltd | Transport & logistics | 2014 |
| ST Anthonys Residential Home (Erdington) Limited | Health & social care | 2007 |
| ST Prime Ltd | Wholesale & retail | 2026 |
| Staff Network Solutions Limited | Professional & scientific | 2015 |
| Stainless & Alloy Products Limited | Manufacturing | 1987 |
| Stance Group Limited | Manufacturing | 2025 |
| Stanleymill Ltd | Hospitality | 2022 |
| Star Courier U.K. Ltd | Transport & logistics | 2024 |
| Star Driveways WM Ltd | Construction | 2024 |
| Star Lift Aviation Services Limited | Transport & logistics | 2023 |
| Starlit Soirées Ltd | Arts & recreation | 2023 |
| Starta Properties Ltd | Real estate | 2026 |
| Starzn Ltd | Transport & logistics | 2026 |
| Stassen Properties Limited | Real estate | 2018 |
| Station Road Bromsgrove Projects Limited | Construction | 2021 |
| Steam Empire Cleaning Ltd | Administrative & support | 2025 |
| Steamdale Limited | Extraterritorial | 1989 |
| Steel & Alloy Holdings Limited | Professional & scientific | 1997 |
| Steel & Alloy Processing Limited | Manufacturing | 1968 |
| Steel Sections (Warley) Limited | Manufacturing | 1977 |
| Steelhaus Fabrication Limited | Professional & scientific | 2025 |
| STEFAN07 Trans Ltd | Transport & logistics | 2025 |
| Stella Maris Practice Limited | Health & social care | 2008 |
| Step Next Limited | Hospitality | 2021 |
| Step Through Homes Limited | Real estate | 2024 |
| Step Through Rehab and Therapy Limited | Health & social care | 2021 |
| Stephanie Jobson Ltd | Households | 2014 |
| Stephen Support Services Ltd | Health & social care | 2015 |
| Sterling Facilities Management (UK) Ltd | Public administration | 2023 |
| Sterling Keys DXB Marketing Agency Ltd | Professional & scientific | 2025 |
| Steve NAR Ltd | Real estate | 2016 |
| Stevens Taxation Services Limited | Professional & scientific | 2008 |
| Stitchsavvy Creations Ltd | Financial services | 2024 |
| Stkl UK Ltd | Construction | 2025 |
| STM Builders Ltd | Construction | 2019 |
| Stokes Scaffolding Solutions Ltd | Construction | 2024 |
| Stone Cross Bar and Grill Ltd | Hospitality | 2025 |
| Stone Cross Car Wash Ltd | Administrative & support | 2026 |
| Stone Square Surfaces Ltd | Wholesale & retail | 2025 |
| Stonebuild Constructions Ltd | Construction | 2026 |
| Stonecross Local Limited | Wholesale & retail | 2022 |
| Store 4 More Limited | Wholesale & retail | 2018 |
| Storerun Ltd | Wholesale & retail | 2025 |
| Storey Marketing Ltd | Professional & scientific | 2022 |
| Storm Wheels Ltd | Wholesale & retail | 2024 |
| Stratford Parcels Force Limited | Transport & logistics | 2025 |
| Street Dog Leisure Ltd | Hospitality | 2025 |
| Stronger Than the Past Ltd | Hospitality | 2018 |
| Student Network Inc Ltd | Wholesale & retail | 2022 |
| Studio 14 Ltd | Professional & scientific | 2012 |
| Studio 25 Nails Ltd | Other services | 2025 |
| Studio Damage Limited | Wholesale & retail | 2026 |
| Studley Ltd | Administrative & support | 2025 |
| SUA Soloutions Ltd | Transport & logistics | 2025 |
| Succeed Training and Recruitment Limited | Education | 2017 |
| Sudera Developments Ltd | Construction | 2015 |
| Sufwan Ahmed Ltd | Administrative & support | 2025 |
| Suhana Living CIC | Real estate | 2025 |
| Sukhdev Singh Ltd | Construction | 2013 |
| Sukhi's Beauty Salon Ltd | Other services | 2019 |
| Sukhmani Ltd | Real estate | 2019 |