| Securepharma UK Limited | Wholesale & retail | 2023 |
| Sedahami Limited | Construction | 2018 |
| Sedgley Homes Limited | Real estate | 2014 |
| Sedia Limited | Construction | 2019 |
| Sedtrade Limited | Wholesale & retail | 2017 |
| Sedtrade Properties Limited | Hospitality | 2018 |
| Seeds Court (Brownhills) Management Company Limited | Households | 2023 |
| Seek Tech Solutions Limited | Information & communication | 2015 |
| Sefels Limited | Professional & scientific | 2022 |
| Sefton People Consulting Limited | Administrative & support | 2024 |
| Sehyon Ltd | Health & social care | 2014 |
| Seismit Limited | Information & communication | 2016 |
| Selann Group Ltd | Wholesale & retail | 2025 |
| Self Axis Haven CIC | Education | 2026 |
| Self Storage Systems Ltd | Manufacturing | 2021 |
| Selines Candles Co Ltd | Manufacturing | 2026 |
| Sell Essentials Ltd | Wholesale & retail | 2023 |
| Sellerzworld Ltd | Wholesale & retail | 2018 |
| Sellmotor Ltd | Wholesale & retail | 2019 |
| Sellnet International Limited | Information & communication | 2016 |
| Selma Healthcare Ltd | Health & social care | 2022 |
| Send Signals Limited | Information & communication | 2026 |
| Senior Smiles Ltd | Health & social care | 2025 |
| Sensavi Ltd | Wholesale & retail | 2023 |
| Sense 6 Software Limited | Information & communication | 2009 |
| Sensory Toy Warehouse Limited | Education | 2018 |
| Sensory Toys Ltd | Education | 2023 |
| Sensynium Limited | Administrative & support | 2004 |
| Sentastix Community Access CIC | Arts & recreation | 2026 |
| Sentastix Ltd | Arts & recreation | 2025 |
| Sentire-Sensory UK Ltd | Wholesale & retail | 2022 |
| Sentricare Limited | Health & social care | 2007 |
| Seolad Global Services Limited | Construction | 2023 |
| Separate Limited | Wholesale & retail | 2017 |
| Sepsis Enterprises Limited | Public administration | 2015 |
| Sepura Technologies Ltd | Extraterritorial | 2022 |
| Seraphic Solutions Ltd | Health & social care | 2023 |
| Serendipity Scents Limited | Manufacturing | 2011 |
| Serenity Care and Support Ltd | Health & social care | 2019 |
| Serenity Divorce & Separation Ltd | Administrative & support | 2026 |
| Serenity Health and Social Care Group Limited | Health & social care | 2010 |
| Serenity Innovations Limited | Health & social care | 2010 |
| Serenity IT Heights Ltd | Information & communication | 2016 |
| Serenvia Limited | Wholesale & retail | 2025 |
| Sergio's Unisex Hairdressing Limited | Other services | 2003 |
| Sergiurusu Ltd | Transport & logistics | 2024 |
| Sertech Ltd | Wholesale & retail | 2024 |
| Sertronics Commercial Ltd | Manufacturing | 2019 |
| Serve & Care Home Service's Ltd | Health & social care | 2025 |
| Service My PC Limited | Information & communication | 2005 |
| Servo Automation Ltd | Construction | 2013 |
| Sesame Lets Ltd | Real estate | 2021 |
| Set&Co Limited | Wholesale & retail | 2018 |
| Setlyr Limited | Professional & scientific | 2026 |
| Setno Holdings Limited | Professional & scientific | 2009 |
| SEV Homes Ltd | Real estate | 2021 |
| SEV Support Ltd | Health & social care | 2024 |
| Severn Gorge Park Homes Limited | Hospitality | 1996 |
| Severn Valley Lamb Limited | Manufacturing | 2009 |
| SFA Services Midlands Ltd | Transport & logistics | 2024 |
| Sfai Consultancy Ltd | Other services | 2023 |
| Sfalex Ltd | Wholesale & retail | 2026 |
| SFD Construction Limited | Construction | 2017 |
| SFS Properties (Walsall) Limited | Real estate | 2024 |
| SG Group U.K Limited | Wholesale & retail | 2025 |
| SG Heath Advisory Limited | Public administration | 2025 |
| SGB ALL Terrain Limited | Manufacturing | 2015 |
| SGB Civil Engineering Ltd | Construction | 2017 |
| SGB High Mobility Vehicles Limited | Manufacturing | 2022 |
| SGE Flooring Limited | Wholesale & retail | 2025 |
| Sgfcb Limited | Information & communication | 2021 |
| SGJ Holdings (WM) Limited | Real estate | 2019 |
| SGJ Telecoms Ltd | Information & communication | 2020 |
| SGN Associates Limited | Professional & scientific | 2012 |
| Sgsg Capital Limited | Construction | 2025 |
| SH Construct Limited | Construction | 2014 |
| SHA Best Cuts Ltd | Other services | 2025 |
| Shaan Consulting Ltd | Professional & scientific | 2025 |
| Shaanik Limited | Wholesale & retail | 2020 |
| Shabab Estates Ltd | Real estate | 2023 |
| Shabsstore Limited | Wholesale & retail | 2022 |
| Shadab Global Ltd | Wholesale & retail | 2014 |
| Shadab Homes Ltd | Wholesale & retail | 2025 |
| Shadow Dragon Properties Ltd | Real estate | 2023 |
| Shah Legal Ltd | Professional & scientific | 2024 |
| Shah Locum Limited | Health & social care | 2005 |
| Shahi Grill Balti Limited | Hospitality | 2018 |
| Shahid Engineering Consultancy Ltd | Professional & scientific | 2025 |
| Shahz Carpentry Ltd | Construction | 2026 |
| Shak Barber Ltd | Other services | 2025 |
| Shak Car Wash Ltd | Administrative & support | 2024 |
| Shak's Carwash Ltd | Administrative & support | 2023 |
| Shake Sensation Ltd | Professional & scientific | 1996 |
| Shakes 'N' Waffles Ltd | Hospitality | 2020 |
| Shakespeare UK Ltd T/A Shakespeare Building Solutions and Services Ltd | Construction | 2026 |
| Shakiru Solutions Ltd | Information & communication | 2025 |
| Shaks Motors Ltd | Wholesale & retail | 2018 |
| Shakti Transport Ltd | Transport & logistics | 2021 |
| Shal Limited | Construction | 2015 |
| Sham Optical Limited | Education | 2024 |