| Shamass Shah Ltd | Transport & logistics | 2019 |
| Shamrock Stays Ltd | Real estate | 2024 |
| Shankar Haulage Ltd | Transport & logistics | 2018 |
| Shanley Projects Limited | Construction | 2015 |
| Shannon Limited | Real estate | 2025 |
| Shapes Art Services Ltd | Wholesale & retail | 2019 |
| Shar Management Services Limited | Administrative & support | 2020 |
| Share Info Ltd | Other services | 2020 |
| Shareserve Ltd | Financial services | 2010 |
| Shark Refurb Ltd | Construction | 2025 |
| Sharonbrownproperty Ltd | Real estate | 2026 |
| Sharp & Nickless Ltd | Wholesale & retail | 2014 |
| Sharway Limited | Wholesale & retail | 1984 |
| Shaw & Co Properties Ltd | Real estate | 2023 |
| Shaw Legal Consultants LLP | | 2020 |
| Shaw Solutions (Midlands) LLP | | 2015 |
| Shawbirch Ltd | Wholesale & retail | 2019 |
| Shaz Autos Express Ltd | Wholesale & retail | 2025 |
| Shaz Body Shop Limited | Wholesale & retail | 2025 |
| Shearman & Haggett Medical Limited | Health & social care | 2014 |
| Shedworks Trials Ltd | Manufacturing | 2013 |
| Sheeren Mahal Ltd | Hospitality | 2024 |
| Sheikh Waqas Limited | Transport & logistics | 2012 |
| Shelco Machines Limited | Manufacturing | 2007 |
| Shelfield Bar and Kitchen Ltd | Hospitality | 2026 |
| Shelfield Pizza & Fish Bar Ltd | Hospitality | 2024 |
| Shemoore Limited | Wholesale & retail | 2019 |
| Shepherds of Walsall Limited | Professional & scientific | 2014 |
| Shepherds Spring Pharmacy Limited | Wholesale & retail | 1985 |
| Shergill Electrical Services Ltd | Construction | 2026 |
| Sheridan Myers Management Services LLP | | 2009 |
| Shermin Finance Limited | Financial services | 1976 |
| SHF Associates Ltd | Health & social care | 2023 |
| Shiijee Logistics Ltd | Transport & logistics | 2025 |
| Shimla Peppers Bar & Grill Ltd | Hospitality | 2024 |
| Shimlapeppersbg Limited | Hospitality | 2026 |
| Shine PIX Limited | Professional & scientific | 2009 |
| Shine Valeting and Tyres Ltd | Wholesale & retail | 2025 |
| Shinebaum & Son's Property Ltd | Real estate | 2016 |
| Shinebeautybrowbar Ltd | Other services | 2014 |
| Shing Enterprises Ltd | Wholesale & retail | 2024 |
| Shinga and BEE Ltd | Administrative & support | 2025 |
| Shipserv Maritime Holdings Ltd | Manufacturing | 2024 |
| Shireoak Automotive Ltd | Wholesale & retail | 2024 |
| Shireoak Motorcycles Ltd | Wholesale & retail | 2024 |
| Shires Oak Joinery Limited | Construction | 2005 |
| Shirlton Car Sales (Staffs) Limited | Wholesale & retail | 2015 |
| Shirlton Car Sales Limited | Wholesale & retail | 2023 |
| Shirlton Cars Limited | Wholesale & retail | 2023 |
| Shiv Construction Ltd | Construction | 2017 |
| Shiv Gardens Ltd | Health & social care | 2017 |
| Shiva Fashions Ltd | Wholesale & retail | 2015 |
| Shivaaru Ltd | Real estate | 2025 |
| Shivashankar Groups Ltd | Hospitality | 2025 |
| Shivaye Property and Development Ltd | Real estate | 2024 |
| Shivs Properties Limited | Real estate | 2020 |
| Shivv Gardens Ltd | Health & social care | 2022 |
| Shivv Gardens Properties Ltd | Real estate | 2023 |
| Shka Investment Limited | Real estate | 2025 |
| Shoaib & Sons Ltd | Real estate | 2025 |
| Shoc Consultancy Ltd | Construction | 2013 |
| Shopex Inn Ltd | Wholesale & retail | 2020 |
| SHOPNETIC365 Ltd | Wholesale & retail | 2025 |
| Shotblast & Coatings Ltd | Construction | 2024 |
| Shotspot Limited | Manufacturing | 2011 |
| Showroom Spec Ltd | Wholesale & retail | 2020 |
| SHR Plumbing & Heating Ltd | Wholesale & retail | 2021 |
| Shree Shyam Logistics Limited | Transport & logistics | 2024 |
| Shrewsbury Arms Albrighton Limited | Hospitality | 2009 |
| Shro Properties Limited | Real estate | 2020 |
| Shropshire Demolition & Reclamation Limited | | 1985 |
| Shropshire Property Maintenance Limited | Construction | 2021 |
| SHS Balustrades & Handrails Ltd | Manufacturing | 2016 |
| SHS Trading Stores Ltd | Wholesale & retail | 2019 |
| Shubh Properties LLP | | 2023 |
| Shutter and Repairs Limited | Construction | 2022 |
| Shyni Enterprises Ltd | Health & social care | 2015 |
| SI Electrical GAS & Plumbing Ltd | Construction | 2018 |
| SI Luhar Ltd | Health & social care | 2023 |
| SIA & Co Limited | Professional & scientific | 2014 |
| SIA Estates Ltd | Real estate | 2019 |
| SIA LUX Group Ltd | Households | 2024 |
| SIA Synergy Ltd | Wholesale & retail | 2020 |
| Sial Limited | Hospitality | 2011 |
| Siam Smile B&M Limited | Other services | 2026 |
| Siamas Enterprises Limited | Health & social care | 2026 |
| Siap Ltd | Extraterritorial | 2023 |
| SID Enterprise Ltd | Other services | 2024 |
| Siddika Interiors Ltd | Wholesale & retail | 2022 |
| Sidechain Limited | Information & communication | 2012 |
| Sidhu Brothers Builders Ltd | Construction | 2019 |
| Sidley Piper Homes Ltd | Construction | 2016 |
| Sielaff UK Limited | Administrative & support | 1998 |
| Siga Transport & Logistics Ltd | Transport & logistics | 2026 |
| Sigauke Ltd | Financial services | 2025 |
| Sigauke Trading Ltd | Financial services | 2025 |
| Sigma Accountants & Tax Advisors Limited | Professional & scientific | 2018 |
| Sigma Engineering (UK) Limited | Manufacturing | 2022 |
| Sign Techniques Limited | Manufacturing | 1996 |
| Signate Consulting Limited | Professional & scientific | 2017 |