| Sars Facilities Management Ltd | Administrative & support | 2026 |
| Sarthak Sharma Traders Limited | Construction | 2024 |
| Sarven Consulting Ltd | Administrative & support | 2024 |
| Sarwan Developments Limited | Administrative & support | 2017 |
| SAS Computer Consultancy Limited | Information & communication | 2010 |
| Sasr Ltd | Wholesale & retail | 2021 |
| Sassen Engineering Ltd. | Manufacturing | 1964 |
| Sassen Holdings Limited | Real estate | 2009 |
| Sassis Kitchen Ltd | Hospitality | 2025 |
| Sassy Bling Fashions Ltd Limited | Manufacturing | 2025 |
| SAT Sahib Logistics Limited | Transport & logistics | 2023 |
| Satchrome Holdings Limited | Financial services | 2026 |
| Satchrome Limited | Manufacturing | 1965 |
| Satori Investment Group Ltd | Financial services | 2025 |
| Saturn Media Systems Ltd | Information & communication | 2023 |
| Saunders Power Services Ltd | Extraterritorial | 2023 |
| Savace Limited | Health & social care | 2008 |
| Savanna Property & Construction Limited | Construction | 2020 |
| Savannah's 1ST Class Foods Ltd | Hospitality | 2014 |
| Save Direct Limited | Financial services | 2003 |
| Save Money on Calls.Net Ltd. | Information & communication | 2009 |
| Savelle Limited | Wholesale & retail | 2026 |
| Savin Heating and Pipework Services Limited | Administrative & support | 2007 |
| Savior Care Ltd | Health & social care | 2022 |
| Savor Food and Drinks Ltd | Wholesale & retail | 2017 |
| Savoy Housing Group Limited | Real estate | 2021 |
| Savvy Rentals Ltd | Real estate | 2025 |
| Sawcon Construction Services Ltd | Professional & scientific | 2019 |
| Sawcraft Limited | Construction | 2004 |
| Saws Properties Limited | Real estate | 2024 |
| Saxon Homes Limited | Real estate | 2021 |
| Saxon Young Ltd | Manufacturing | 2019 |
| Saxonworld Limited | Construction | 2011 |
| Sayad Ltd | Transport & logistics | 2021 |
| Sayarts.Com CIC | Arts & recreation | 2008 |
| Sayid Ltd | Wholesale & retail | 2021 |
| Sayn Luxe Limited | Wholesale & retail | 2023 |
| Sayq Limited | Hospitality | 2021 |
| SAZ Commerce Ltd | Wholesale & retail | 2026 |
| SB Bathroom & Property Services Ltd | Construction | 2025 |
| SB Foods Trading Limited | Wholesale & retail | 2021 |
| SB Investments (BS) Limited | Real estate | 2025 |
| SB Medical Healthcare Limited | Health & social care | 2017 |
| SB Properties Investment Ltd | Real estate | 2022 |
| SBA Capital Ltd | Real estate | 2024 |
| Sbcm Limited | Wholesale & retail | 2023 |
| SBP Capital Limited | Real estate | 2019 |
| SBS Academy Ltd | Wholesale & retail | 2025 |
| SBT Cleaning Services Limited | Administrative & support | 2003 |
| Sbtv Global Ltd | Administrative & support | 2010 |
| SC & SC Limited | Professional & scientific | 2021 |
| SCA Cleaning Ltd | Administrative & support | 2026 |
| Scalebridge Commerce Limited | Wholesale & retail | 2026 |
| Scales Electrical Ltd | Construction | 2026 |
| Scalini Properties Ltd | Real estate | 2015 |
| Scalps Revitalised Ltd | Other services | 2026 |
| Scanabox Ltd | Information & communication | 2024 |
| Scape Communications Ltd | Construction | 2022 |
| Sceneplan Limited | Wholesale & retail | 1988 |
| Schloss Properties Ltd | Real estate | 2026 |
| Schmidt PA Limited | Administrative & support | 2019 |
| Schofield Consulting Limited | Administrative & support | 2011 |
| Schon Limited | Wholesale & retail | 2015 |
| School Walk Management (NO.1) Limited | Households | 1993 |
| Scientific Venture Partners Limited | Professional & scientific | 2020 |
| SCN UK Group Ltd | Professional & scientific | 1987 |
| Scooper Deals Ltd | Wholesale & retail | 2021 |
| Scorpio Welding & Fabrications Limited | Administrative & support | 2009 |
| Scorpion Consultants Ltd | Financial services | 2018 |
| Scott Enterprise (Plant Hire) Limited | Construction | 1984 |
| Scott Manor Properties (2018) Limited | Households | 2018 |
| Scott Worrall Design and Decor Ltd | Construction | 2026 |
| Scribmare Ltd | Transport & logistics | 2024 |
| Scriptcare Limited | Wholesale & retail | 2012 |
| Scrj Ltd | Real estate | 2017 |
| Scry Limited | Professional & scientific | 2013 |
| SCS Consultancy (Midlands) Limited | Administrative & support | 2024 |
| Sculpt FB Ltd | Other services | 2021 |
| Sculpturauk Limited | Other services | 2025 |
| SDG Sylvia Ltd | Extraterritorial | 2022 |
| SDL Consultancy and Projects Ltd | Professional & scientific | 2026 |
| SDP Skiphire Ltd | Transport & logistics | 2025 |
| SDR Removals Ltd | Transport & logistics | 2021 |
| SDW Driver Services Limited | Transport & logistics | 2016 |
| Seagull Fish Bar Ltd | Hospitality | 2016 |
| Seak I.T Support Limited | Other services | 2020 |
| Seal Fuels Limited | Wholesale & retail | 2010 |
| Sealtight West Midlands Ltd | Construction | 2025 |
| Sean Mcgaan Home Improvements Limited | Wholesale & retail | 2009 |
| Seasons Rehabilitation Centre Limited | Health & social care | 2014 |
| Seastrike Boats Limited | Manufacturing | 2005 |
| Sebastian Thomas Limited | Water & waste | 2024 |
| Second Catch Ltd | Health & social care | 2014 |
| Secrets Cosmetics Aask Ltd | Wholesale & retail | 2022 |
| Sectoredge Ltd | Professional & scientific | 2018 |
| Secure Bolting Systems Ltd | Professional & scientific | 2016 |
| Secure EYE Cctv & Alarms Ltd | Construction | 2020 |
| Secure Marketing Limited | Other services | 2019 |
| Secure Ride Services Ltd | Transport & logistics | 2026 |
| Securelex Ltd | Construction | 2018 |