| Sakura PDC Limited | Construction | 2026 |
| Sal-Vation (Midlands) C.I.C. | Health & social care | 2023 |
| Sal-Vation Health & Fitness Ltd | Health & social care | 2023 |
| Salam Butchers Limited | Hospitality | 2025 |
| Sale Smith & Co Limited | Professional & scientific | 2005 |
| Saledirect Ltd | Wholesale & retail | 2024 |
| Sales Republic UK Ltd | Administrative & support | 2026 |
| Salesmart Ltd | Wholesale & retail | 2025 |
| Salient Sense Limited | Manufacturing | 2017 |
| Salient Vision Limited | Information & communication | 2017 |
| Salina Sleep Consultant Ltd | Administrative & support | 2025 |
| Salloo’S Ltd | Wholesale & retail | 2025 |
| Salmarix Ltd | Wholesale & retail | 2025 |
| Salt & Pepper Walsall Limited | Hospitality | 2024 |
| Salt and Light Ministries | Other services | 1998 |
| Salt N Chilli Ltd | Hospitality | 2025 |
| Salus Medica Ltd | Other services | 2023 |
| SAM Apple Ltd | Information & communication | 2016 |
| SAM Kang Limited | Education | 2005 |
| SAM Security Systems Ltd | Administrative & support | 2021 |
| Samancy Ltd | Wholesale & retail | 2024 |
| Samantha Grace Aesthetic's Ltd | Other services | 2025 |
| Samba Foods Ltd | Wholesale & retail | 2020 |
| Sameday Haulage Limited | Transport & logistics | 2014 |
| Sami Retail Group Ltd | Wholesale & retail | 2021 |
| Samii Foods Limited | Transport & logistics | 2015 |
| Samjac Construction Limited | Manufacturing | 2012 |
| Sammatworks Ltd | Health & social care | 2020 |
| Sammie Social Ltd | Professional & scientific | 2025 |
| Samnega Capital Ltd | Real estate | 2025 |
| Samnega Ltd | Health & social care | 2025 |
| Samrai Hospitality Limited | Hospitality | 2024 |
| Samrat Construction Ltd | Construction | 2021 |
| Sams Traffic Solutions Ltd | Construction | 2024 |
| Sams Vehicle Solutions Limited | Wholesale & retail | 2018 |
| Sams Visuals Ltd | Information & communication | 2026 |
| Samson Apps Limited | Information & communication | 2015 |
| Samuel Property Solutions Limited | Real estate | 2018 |
| Samuel Wilkes (Engineering) Limited | Manufacturing | 1979 |
| Samukwane Ltd | Administrative & support | 2026 |
| Samwan Tech Ltd | Professional & scientific | 2024 |
| Samz Soultions Ltd | Other services | 2025 |
| Samzautosmartz Ltd | Wholesale & retail | 2024 |
| Samzir Services Limited | Construction | 2025 |
| Sanctuary Hairdressers Limited | Other services | 2018 |
| Sanctuary of the Wandering Palm Limited | Other services | 2025 |
| Sanctuary Social Care Solutions Ltd | Public administration | 2021 |
| Sanctuary Sunbeds & Products Limited | Other services | 2024 |
| Sanctum Technologies Ltd | Information & communication | 2026 |
| Sanctus Health Solutions Ltd | Health & social care | 2025 |
| Sandbank Fish Bar Ltd | Wholesale & retail | 2018 |
| Sanders Midlands Investments Limited | Real estate | 2024 |
| Sandfords Construction Limited | Construction | 1993 |
| Sandhar Property Ltd | Real estate | 2023 |
| Sandhar Travel Ltd | Transport & logistics | 2026 |
| Sandhawalia Transport Ltd | Manufacturing | 2025 |
| Sandhu & Bains Estates Limited | Real estate | 2023 |
| Sandhu Portfolio Ltd | Real estate | 2024 |
| Sandhu Traders Limited | Wholesale & retail | 2020 |
| Sandiehealthcare Ltd | Administrative & support | 2017 |
| Sandiezcollectionuk Ltd | Wholesale & retail | 2024 |
| Sandwell Bright Futures Homecare Ltd | Health & social care | 2025 |
| Sandwell Field Sports Ltd | Wholesale & retail | 2024 |
| Sandwell Glass & Glazing Ltd | Construction | 2023 |
| Sandwell Property Group Ltd | Real estate | 2026 |
| Sandwell Street Garage Limited | Manufacturing | 2013 |
| Sandwiches Ltd | Hospitality | 2026 |
| Sandy & Co Ltd | Administrative & support | 2011 |
| Sandy & Co. (Contractors) Limited | Construction | 1963 |
| Sandy Healthcare Limited | Health & social care | 2022 |
| Sangha Prime Estates Ltd | Real estate | 2024 |
| Sangha Projects Limited | Construction | 2016 |
| Sanghera Acquisitions Ltd | Construction | 2018 |
| Sangwan Limited | Construction | 2025 |
| Sanjhi Sewa Ltd | Health & social care | 2017 |
| Sanjhi Sewa Records Ltd | Information & communication | 2025 |
| Sanju Paras Limited | Wholesale & retail | 2023 |
| Sankey's TAP House Ltd | Hospitality | 2017 |
| Sanraj Property Group Ltd | Real estate | 2023 |
| Sanrub Store Limited | Hospitality | 2023 |
| Sans Construction Ltd | Construction | 2019 |
| Sans Site Services Ltd | Administrative & support | 2021 |
| Sanshay Ltd | Health & social care | 2010 |
| Sanunis Ltd | Wholesale & retail | 2019 |
| SAP (West Midlands) Ltd. | Manufacturing | 2019 |
| SAP Investments Limited | Real estate | 2013 |
| Sapphire and Pearls Ltd | Other services | 2014 |
| Sapphire SEN Transport Ltd | Transport & logistics | 2026 |
| Sapphire SEN Travel Ltd | Transport & logistics | 2026 |
| Sapphire Studymed Global Ltd | Education | 2025 |
| Sara and Silas Limited | Information & communication | 2024 |
| Sarah Doherty Online Ltd | Information & communication | 2019 |
| Sarah's Cafe Ltd | Hospitality | 2026 |
| Sarah’S Rescue Bites Limited | Hospitality | 2025 |
| Sarao Studios Ltd | Information & communication | 2021 |
| Sarapharm Ltd | Health & social care | 2020 |
| Saratoga Cars Limited | Wholesale & retail | 2020 |
| Sardar Jewellers Limited | Wholesale & retail | 2021 |
| Sare UK Limited | Wholesale & retail | 2019 |
| Sarr Holdings UK Ltd | Financial services | 2025 |