| S&W SEC Group Holdings Ltd | Information & communication | 2023 |
| S. & R. Rowan Racing Limited | Extraterritorial | 1989 |
| S. Kumari & Associates Limited | Health & social care | 2008 |
| S.A Rides Ltd | Transport & logistics | 2025 |
| S.Ah Optics Ltd | Wholesale & retail | 2022 |
| S.C.G Heating Ltd | Construction | 2020 |
| S.E. Food Group Limited | Professional & scientific | 2012 |
| S.E.L.F. (SEE Every Life Fulfilled) CIC | Health & social care | 2019 |
| S.G.P Carpentry Limited | Construction | 2017 |
| S.I. Pharma Ltd | Health & social care | 2021 |
| S.J Hair (Midlands) Limited | Other services | 2021 |
| S.J.L.N.A. Holdings Limited | Real estate | 2026 |
| S.J.L.N.A. Property Investments Ltd | Real estate | 2023 |
| S.J.L.N.A. Property Management LLP | | 2023 |
| S.Kaushal Investments Ltd | Real estate | 2022 |
| S.R.Legacy Lettings Ltd | Real estate | 2019 |
| S.T.A.R. (Striving to Achieve Results) C.I.C. | Arts & recreation | 2015 |
| S.T.B. Polishing Limited | Manufacturing | 2003 |
| S.W. Plumbing and Heating Service Limited | Construction | 2001 |
| S2 Capital Developments Limited | Real estate | 2026 |
| S43MA Legal Ltd | Professional & scientific | 2025 |
| S4LC Limited | Health & social care | 2024 |
| SA 80 Ltd | Hospitality | 2025 |
| SA Food and Grill Ltd | Hospitality | 2019 |
| SA Investments (BS) Limited | Real estate | 2025 |
| SA Midlands Property Ltd | Real estate | 2025 |
| SA Prop Co Ltd | Real estate | 2025 |
| SA Stourbridge Limited | Wholesale & retail | 2025 |
| Saachi Ltd | Real estate | 2024 |
| Saachii (Chiswick) Ltd | Real estate | 2024 |
| Saachii (Kensington) Ltd | Real estate | 2024 |
| Saad Enterprises Ltd | Real estate | 2018 |
| Saasware Ltd | Wholesale & retail | 2024 |
| Saavan Boutique Ltd | Wholesale & retail | 2024 |
| SAB Trans Ltd | Transport & logistics | 2019 |
| Sabb-Tera Ltd | Professional & scientific | 2026 |
| Sada Diagnostics Limited | Health & social care | 2010 |
| Sadak Ltd | Construction | 2026 |
| Saddlers Bench Limited | Manufacturing | 2011 |
| Saddlers Court MFG Ltd | Manufacturing | 2006 |
| Saddlers Garage Ltd | Wholesale & retail | 2003 |
| Saddlers Tyre Services Ltd | Wholesale & retail | 2025 |
| Saddlersmms Limited | Hospitality | 2024 |
| Sadera Properties Ltd | Real estate | 2020 |
| Sadera Solutions Ltd | Information & communication | 2018 |
| Sadi Group Ltd | Wholesale & retail | 2025 |
| Sadique Holdings Ltd | Real estate | 2017 |
| Sadlers Mill Limited | Households | 2000 |
| Safari Braai Shack Limited | Hospitality | 2024 |
| Safe Guardian Security Limited | Administrative & support | 2024 |
| Safe Hands Training Sevices Ltd | Health & social care | 2018 |
| Safe Height Scaffold Solutions Ltd | Construction | 2026 |
| Safe Journey for Young People Ltd | Education | 2024 |
| Safe Living Furniture Ltd | Manufacturing | 2023 |
| Safe My Life Recruitment Ltd | Public administration | 2024 |
| Safe Start Homes Limited | Real estate | 2025 |
| Safeguard Doors Limited | Extraterritorial | 2013 |
| Safehaven Mulla Limited | Real estate | 2026 |
| Safelane Transfers Ltd | Transport & logistics | 2026 |
| Safelec Contractors Ltd | Construction | 2016 |
| Saferest Consortia Limited | Information & communication | 2025 |
| Safety Training Apprenticeships Ltd | Education | 2018 |
| Safety Training Awards Limited | Education | 2005 |
| Safetystop Ltd | Manufacturing | 2020 |
| Saffrons Garage Ltd | Wholesale & retail | 2011 |
| Safi Associates Ltd | Real estate | 2024 |
| Safi Bros Cars Ltd | Wholesale & retail | 2024 |
| Sage & Bloom Ltd | Information & communication | 2022 |
| Sage & Company Business Advisors Limited | Professional & scientific | 2003 |
| Saggu Fittings Ltd | Wholesale & retail | 2024 |
| Saggu Slide Doors Ltd | Wholesale & retail | 2024 |
| Sagoo Photography Limited | Professional & scientific | 2025 |
| SAH Care Limited | Health & social care | 2018 |
| Saha Business Consultancy Limited | Financial services | 2025 |
| Saha Consultancy Ltd | Health & social care | 2018 |
| Sahara Accountancy Services Ltd | Professional & scientific | 2023 |
| Sahara Day Care Centre CIC | Public administration | 2019 |
| Sahay Medical Services Limited | Real estate | 2011 |
| Sahib Haulage Ltd | Transport & logistics | 2022 |
| Sahib Nahal Limited | Real estate | 2025 |
| Sahib Property Holdings Ltd | Real estate | 2025 |
| Sahota & SON Transport Ltd | Transport & logistics | 2021 |
| Saif Autos Walsall Ltd | Wholesale & retail | 2022 |
| Saif Qamar Properties Limited | Real estate | 2025 |
| Saigon Nails & Spa Bar Limited | Other services | 2022 |
| Saine Auto Solutions Ltd | Wholesale & retail | 2026 |
| Saini Ltd | Hospitality | 2025 |
| Sainsway Ltd | Hospitality | 2023 |
| Saint Mary Medica Limited | Health & social care | 2019 |
| Sainte Cécile Ltd | Other services | 2015 |
| Saints Church | Health & social care | 2019 |
| Saints Consultancy Studios Limited | Professional & scientific | 2024 |
| Saira's Grill Ltd | Hospitality | 2024 |
| Saito Pictures Limited | Information & communication | 2017 |
| SAJ Associates Ltd | Professional & scientific | 2014 |
| Saje Care Group Limited | Health & social care | 2025 |
| Saker Couriers Ltd | Transport & logistics | 2025 |
| Sakina Education and Skills | Education | 2015 |
| Sakura FIC Limited | Financial services | 2025 |
| Sakura Grappling Limited | Arts & recreation | 2021 |