| Sempiternal Strong Ltd | Arts & recreation | 2018 |
| Senco Services Ltd | Education | 2023 |
| Sensory Corner Ltd | Wholesale & retail | 2021 |
| Serfix Ltd | Administrative & support | 2026 |
| Seva Training Limited | Education | 2010 |
| Sevalis Technical Limited | Professional & scientific | 2025 |
| Seven System Ltd | Arts & recreation | 2026 |
| Seven-One Group Ltd | Financial services | 2024 |
| SG Deliveries Ltd | Transport & logistics | 2025 |
| SGB Electrical Contractors Ltd | Construction | 2023 |
| Sh-Syndicate Ltd | Agriculture & fishing | 2020 |
| Shadowline Transport Ltd | Transport & logistics | 2026 |
| Shapechef Ltd | Manufacturing | 2024 |
| Shared Healing Collective CIC | Health & social care | 2023 |
| Sharp Accounting Limited | Professional & scientific | 2012 |
| Shauna L White Ltd | Professional & scientific | 2014 |
| Shaw Success Partner Ltd | Professional & scientific | 2024 |
| Shco Climbing Ltd | Professional & scientific | 2021 |
| Shea Homes Limited | Real estate | 2021 |
| Shea Investments Ltd | Real estate | 2022 |
| Shearwater Ltd | Administrative & support | 2018 |
| Sheds R US Limited | Manufacturing | 2016 |
| Sheena Morgan Ltd | Health & social care | 2015 |
| Shine Together Always CIC | Public administration | 2025 |
| Showstopper Supplies Ltd | Wholesale & retail | 2019 |
| Showtime Ice Cream Ltd | Wholesale & retail | 2012 |
| Shufflewoods Ltd | Manufacturing | 2021 |
| Siam Supplements Ltd | Administrative & support | 2017 |
| Signtek-Uk Ltd | Manufacturing | 2020 |
| Silkroad Technologies Ltd | Wholesale & retail | 2025 |
| Silver Orchard Homes Ltd | Real estate | 2022 |
| Silverbeech Care Ltd | Health & social care | 2025 |
| Silverstoneroofingandbuildingcontracors Ltd | Construction | 2025 |
| Silverstoneroofingandbuildingcontractors Ltd | Construction | 2025 |
| Simon Hilton Property Ltd | Real estate | 2025 |
| Simple Send-Offs Limited | Other services | 2017 |
| Singhsbury's Trading Limited | Wholesale & retail | 2019 |
| SIS (GB) Training Limited | Professional & scientific | 2020 |
| Sis.Sip Coffee Ltd | Hospitality | 2025 |
| SIX Peas Property Ltd | Construction | 2026 |
| Size Architects Ltd | Professional & scientific | 2015 |
| SJE Linen Services Ltd | Administrative & support | 2025 |
| SJL36 Limited | Hospitality | 2020 |
| Skillo's J.E.R Ltd | Hospitality | 2025 |
| Skimco Property Solutions Ltd | Administrative & support | 2016 |
| Skin Logic Training Limited | Administrative & support | 2017 |
| Skinwithclaire Ltd | Other services | 2025 |
| SKS Professional Consultants Limited | Professional & scientific | 2020 |
| Sky Transformation Ltd | Professional & scientific | 2023 |
| Skyline Roofing & Building Limited | Construction | 2014 |
| Skyn Aesthetic Consultants Ltd | Other services | 2022 |
| Slievenamon Ltd | Professional & scientific | 2026 |
| Small Beginnings Ltd | Hospitality | 2017 |
| Smart Moves Removals Ltd | Transport & logistics | 2024 |
| Smashed & Stacked Limited | Hospitality | 2024 |
| Smdar Ltd | Information & communication | 2023 |
| Smooth Removals (Wirral) Ltd | Other services | 2019 |
| Snapseats Ltd | Administrative & support | 2021 |
| Social Wylde Ltd | Hospitality | 2023 |
| Socialneverbetter Ltd | Professional & scientific | 2025 |
| Sohit Limited | Other services | 2015 |
| Solelluna Ltd | Hospitality | 2026 |
| Soloris Holdings Company (BVI) Ltd | Financial services | 2025 |
| Solstice Projects Ltd | Real estate | 2024 |
| Solwell Ltd | Administrative & support | 2007 |
| Somerville Estates Limited | Real estate | 2020 |
| Sound Media & Marketing Limited | Professional & scientific | 2024 |
| Southside (Buckley) Management Company Limited | Households | 2007 |
| Southside Buckley RTM Company Limited | Households | 2015 |
| Southside NO.2 RTM Company Limited | Households | 2016 |
| Southside NO.3 RTM Company Limited | Households | 2016 |
| Sovex Systems Limited | Professional & scientific | 2025 |
| SP Bars & Events Ltd | Hospitality | 2026 |
| SPD Eco Services Ltd | Construction | 2025 |
| Specialised Unit Engineering Limited | Professional & scientific | 1983 |
| Specialised Unit Handling Limited | Manufacturing | 1980 |
| Specialised Unit Holdings Limited | Professional & scientific | 1983 |
| Specialist Telecoms Limited | Information & communication | 2023 |
| Spectre Security Services Ltd | Financial services | 2025 |
| Spectre Security Systems Ltd | Financial services | 2025 |
| Speech Therapy Works Ltd | Other services | 2021 |
| Speedlec Ltd | Construction | 2025 |
| Spellcast Ltd | Manufacturing | 2026 |
| Spike DR Ltd | Wholesale & retail | 2024 |
| Spike Leisurewear Limited | Professional & scientific | 2015 |
| Spivack Venues Solutions Ltd | Hospitality | 2026 |
| Spring Associates Limited | Professional & scientific | 1990 |
| Spruce Springclean Carpet Cleaning Limited | Administrative & support | 2022 |
| Spudulica Home & Garden Limited | Wholesale & retail | 2021 |
| SQ Promotions Ltd | Arts & recreation | 2017 |
| SQ Property Limited | Real estate | 2024 |
| SRA Property Consultants Limited | Professional & scientific | 2020 |
| ST. George's Court (Management) Wallasey Limited | Households | 1988 |
| Stack & Store NW Ltd | Transport & logistics | 2025 |
| Stanaway Properties Limited | Construction | 2020 |
| Starling Care and Support Services Limited | Health & social care | 2026 |
| Starr Detailing Ltd | Administrative & support | 2026 |
| Staton Price Ltd | Wholesale & retail | 2013 |
| Steady Chef Ltd | Hospitality | 2023 |
| Steele Boxing and Fitness Ltd | Health & social care | 2024 |