| Rich Interpretations Ltd | Professional & scientific | 2024 |
| Rich Print Limited | Manufacturing | 1991 |
| Ridge Skateboards Limited | Professional & scientific | 2021 |
| Riptide Venue Limited | Hospitality | 2025 |
| Riverside Electrical Supplies Ltd | Wholesale & retail | 2011 |
| Riverviewenvironmental Limited | Administrative & support | 2019 |
| RJ CAP Limited | Construction | 2014 |
| RKM Agile Consulting Ltd | Administrative & support | 2016 |
| RM Rope Access Ltd | Construction | 2026 |
| RMJ Installations Ltd | Construction | 2024 |
| RMS Property & Investments Limited | Financial services | 2022 |
| RN Affordable Cars Ltd | Wholesale & retail | 2022 |
| RNL Motors Limited | Administrative & support | 2023 |
| Robbs Garages (Wallasey) Limited | Wholesale & retail | 1976 |
| Robertmccombe Ltd | Professional & scientific | 2025 |
| Robyville Property Ltd | Real estate | 2026 |
| Rock Bike Servicing & Repairs Limited | Wholesale & retail | 2019 |
| Rock Point Leisure Limited | Professional & scientific | 2018 |
| Rocket Theatre Company | Arts & recreation | 1998 |
| Rockland Estate Company Limited | Transport & logistics | 2023 |
| Rocksalt (Wirral) Limited | Real estate | 2013 |
| Rockville Property Services Limited | Construction | 2003 |
| Rockwood Wirral Limited | Hospitality | 2024 |
| Roger Moore Bespoke Kitchens Limited | Construction | 2008 |
| Rojin Pick & PAY Ltd | Wholesale & retail | 2023 |
| Rolling Stock Engineering Ltd | Construction | 2023 |
| Rompass Limited | Administrative & support | 2025 |
| Rosebery Court Management 2016 Limited | Real estate | 2016 |
| Rosell Consulting Ltd | Information & communication | 2025 |
| Rosewood Search Limited | Professional & scientific | 2021 |
| Round Trio Ltd | Hospitality | 2016 |
| Routly Property Limited | Construction | 2026 |
| ROW ROW Productions Limited | Information & communication | 2020 |
| Rowson Court Limited | Administrative & support | 1999 |
| RP Solution Consulting Limited | Information & communication | 2024 |
| RPM Facilities Ltd | Construction | 2026 |
| RPR NB Bars Limited | Hospitality | 2024 |
| RR Cleaning Services Ltd | Administrative & support | 2024 |
| RRG Transport Limited | Transport & logistics | 2025 |
| RRU Management Ltd | Real estate | 2025 |
| RS Professional Property Limited | Administrative & support | 2014 |
| RSF Property Ltd | Real estate | 2022 |
| RT K9 Fertility Clinic Wallasey Limited | Agriculture & fishing | 2022 |
| Running Head First CIC | Health & social care | 2019 |
| Russell Electrical Engineering Design Services Limited | Construction | 2007 |
| Ruth Casaletto Limited | Professional & scientific | 2021 |
| RW Locum Services Limited | Health & social care | 2000 |
| S & E Goldsmiths Limited | Wholesale & retail | 2002 |
| S & J Brady Limited | Hospitality | 2012 |
| S & N Property (NW) Ltd | Real estate | 2025 |
| S a S Retail Ltd | Wholesale & retail | 2019 |
| S&P Property Wirral Ltd | Real estate | 2025 |
| S.T.R Brothers Import & Export Limited | Manufacturing | 2020 |
| SA Consulting & Counselling Limited | Professional & scientific | 2013 |
| SAA Electrical Design Limited | Administrative & support | 2013 |
| SAB Soccer Dome Ltd | Arts & recreation | 2024 |
| Sables Court Limited | Households | 2025 |
| Saborcito Ltd | Hospitality | 2025 |
| SAE Retail Limited | Wholesale & retail | 2023 |
| Safeanchor Transport Services Limited | Transport & logistics | 2026 |
| Safeflow Ventilation Ltd | Administrative & support | 2010 |
| Safepoint Professional Services Ltd | Professional & scientific | 2019 |
| SAFESPACE4U Holdings Ltd | Financial services | 2025 |
| SAFESPACE4U Ltd | Health & social care | 2024 |
| Safety Layne (Investments) Limited | Real estate | 2000 |
| Safis Wallasey Ltd | Hospitality | 2025 |
| Saleemi HR Ltd | Administrative & support | 2024 |
| Salinas (UK) Limited | Real estate | 2008 |
| SAM Douglas SDX Ltd | Education | 2026 |
| SAM Waite Kitchens Ltd | Manufacturing | 2025 |
| Samac Group Ltd | Professional & scientific | 2024 |
| Samelco Automation Systems Limited | Information & communication | 2002 |
| Sandon Road Property Ltd | Real estate | 2017 |
| Sandridge Hotel Ltd | Hospitality | 2025 |
| Sandstone Rise (Oxton) Management Limited | Real estate | 2020 |
| Sarah Mcmahon Podiatry Limited | Health & social care | 2024 |
| SAS Deliveries Ltd | Transport & logistics | 2020 |
| Sasker Limited | Wholesale & retail | 2021 |
| Save Choices Ltd | Wholesale & retail | 2022 |
| Saventa Properties Limited | Real estate | 2013 |
| Sawk Properties Ltd | Real estate | 2026 |
| SB Car and Commercials Wrexham Limited | Wholesale & retail | 2024 |
| SBB Music Ltd | Information & communication | 2022 |
| SBL Property Limited | Real estate | 2026 |
| Scarisbrick Associates Ltd | Professional & scientific | 2022 |
| Scott’S Painting Services Ltd | Construction | 2025 |
| Sea Court Flats Limited | Households | 1966 |
| Seaban Service Ltd | Construction | 2025 |
| Seabank and Dovercliffs Management Company Limited | Households | 1999 |
| Seacombe Soccer Centre Ltd | Arts & recreation | 2018 |
| Sean MAY Mortgages Ltd | Financial services | 2024 |
| Search Estates Ltd | Real estate | 2026 |
| Seascape Management Limited | Households | 1986 |
| Season Swim Ltd | Wholesale & retail | 2019 |
| Season's Software Ltd | Information & communication | 2025 |
| Seaview Motor Service Ltd | Wholesale & retail | 2012 |
| Seaview Sensory Ltd | Wholesale & retail | 2021 |
| Second Chance Games Limited | Wholesale & retail | 2019 |
| Second Wife Limited | Hospitality | 2025 |
| Secret Specialist Limited | Professional & scientific | 2010 |