| Starfire Investments Limited | Real estate | 2021 |
| Starlight Dance Festivals Ltd | Arts & recreation | 2026 |
| Starpups Limited | Professional & scientific | 2025 |
| Stars Mini Market Ltd | Wholesale & retail | 2015 |
| Stativa Passive Fire Protection Ltd | Public administration | 2025 |
| Staunch Consulting Services Limited | Professional & scientific | 2021 |
| Stay Group Limited | Hospitality | 2021 |
| Stayeasy Retals Limited | Real estate | 2024 |
| Stead Jackson Properties Limited | | 1974 |
| Steadfast Machinery Limited | Wholesale & retail | 2004 |
| Steady Building Ltd | Construction | 2023 |
| Steel and Metalwork Products Ltd | Manufacturing | 2012 |
| Steel Installation Services Limited | Manufacturing | 2018 |
| Stefan Rutherford Audio Services Limited | Information & communication | 2016 |
| Stellar Food Group Ltd | Financial services | 2022 |
| Stellar Yang Limited | Manufacturing | 2025 |
| Stellarbrook Demolition Limited | Construction | 2002 |
| Stelram Limited | Manufacturing | 2020 |
| Stelram Medical Limited | Manufacturing | 2013 |
| Stemm Tradings Limited | Professional & scientific | 2017 |
| Sten Architecture Limited | Professional & scientific | 2014 |
| Sten Commercial Limited | Real estate | 2018 |
| Sten Consulting Ltd | Manufacturing | 2025 |
| Stenton and Spencer Properties Ltd | Real estate | 2024 |
| Stenz Professional Ltd. | Administrative & support | 2017 |
| Stephen Evans Holdings Limited | Financial services | 2018 |
| Stephen Gleadhill Painters & Decorators Limited | Construction | 2006 |
| Stephen Ring Ltd | Construction | 2018 |
| Stephens Mechanical Services Ltd | Professional & scientific | 2026 |
| Sterling (MS) Ltd | Real estate | 2016 |
| Sterling House One Limited | Real estate | 2016 |
| Sterling Rise Property Group Ltd | Construction | 2025 |
| Sterlingshopfitters Ltd | Construction | 2025 |
| Stern Ltd | Administrative & support | 2025 |
| Steve Adams Joinery UK Limited | Construction | 2016 |
| Steve Thompson Financial Planning Limited | Financial services | 2014 |
| Steve Wilkinson Engineering Services Ltd | Administrative & support | 2020 |
| Steve Wood Driver Services Ltd | Transport & logistics | 2025 |
| Stevenson's Living Ltd | Real estate | 2024 |
| STH Project Consultancy Ltd | Construction | 2022 |
| Stiering Lives Ltd | Health & social care | 2023 |
| Stiftung Endrik Werin | Real estate | 2016 |
| Stirling Precision Engineering Limited | Professional & scientific | 1985 |
| Stirling Products Limited | Wholesale & retail | 2014 |
| Stitch Express Wakefield Ltd | Other services | 2025 |
| STM Services (NW) Limited | Construction | 2022 |
| STN Management Limited | Wholesale & retail | 2023 |
| Stocker Joinery Services Ltd | Construction | 2024 |
| Stockton Civil Engineering Limited | Construction | 2024 |
| Stockton Drilling Limited | Construction | 2001 |
| Stockton Marine Limited | Administrative & support | 2019 |
| Stoke Commercials Ltd | Manufacturing | 2018 |
| Stone Brick Homes Ltd | Real estate | 2025 |
| Stoneacre Investments Limited | Professional & scientific | 2003 |
| Stonefall Limited | Construction | 2008 |
| Stonekey Projects Ltd | Other services | 2020 |
| Stoneleigh Properties (Wakefield) Limited | Construction | 2010 |
| Stones Family Kitchen Ltd | Extraterritorial | 2019 |
| Storaby Limited | Wholesale & retail | 2026 |
| Storage Maintenance Logisitcs Leeds Ltd | Wholesale & retail | 2020 |
| Storage Maintenance Logistics Ltd | Real estate | 2015 |
| Store of JAM Ltd | Wholesale & retail | 2014 |
| Storm Associates Limited | Administrative & support | 2022 |
| Story Scouts CIC | Arts & recreation | 2022 |
| Strada Projects Limited | Professional & scientific | 2025 |
| Strafford Holdings Limited | Wholesale & retail | 2023 |
| Straight Develop Limited | Real estate | 2007 |
| Straights Global Limited | Manufacturing | 2024 |
| Strata 7 Ltd | Construction | 2019 |
| Stratagem Project Management Limited | Professional & scientific | 2009 |
| Strategica Group Ltd | Information & communication | 2021 |
| Strategyschedule Limited | Wholesale & retail | 1999 |
| Stratton Oakmont BED Manufactures Ltd | Manufacturing | 2019 |
| Straw&Son's Ltd | Construction | 2024 |
| Streamdata Ltd | Construction | 2025 |
| Street Food Hospitality Ltd | Hospitality | 2020 |
| Street Food Kitchen Pudsey Ltd | Hospitality | 2024 |
| Stretton Denman (J27 M62) Ltd | Real estate | 2007 |
| Stride Theatre Ltd | Arts & recreation | 2016 |
| Strong Life Care (Church View) Limited | Health & social care | 2025 |
| Strong Life Care (Cooper House) Limited | Health & social care | 2023 |
| Strong Life Care (Hesslewood House) Limited | Health & social care | 2023 |
| Strong Life Care (OP Co) Holdings Limited | Financial services | 2026 |
| Strong Life Care (Tenlands) Limited | Health & social care | 2023 |
| Strong Life Care (the Beeches) Limited | Health & social care | 2023 |
| Strong Life Care (Tuxford) Limited | Health & social care | 2005 |
| Strong Life Care Limited | Health & social care | 2010 |
| Strong Minds International Ltd | Education | 2022 |
| Structuretech Ltd | Construction | 2016 |
| Struqta Modulr Limited | Construction | 2021 |
| Struston Holdings Limited | Financial services | 2025 |
| Stuart Dodd Ltd | Financial services | 2018 |
| Stuart Marketing Works Ltd | Professional & scientific | 2023 |
| Stuart Pook Financial Services Limited | Financial services | 2021 |
| Stuart Rich Autos Ltd | Wholesale & retail | 2011 |
| Stucco & Stucco Ltd | Administrative & support | 2017 |
| Stucco & Stucco Training Ltd | Administrative & support | 2017 |
| Studio 098 Ltd | Information & communication | 2025 |
| Studio 1284 Limited | Professional & scientific | 2025 |
| Studio ARC Design Limited | Professional & scientific | 2025 |