| Spencer Strategic Consulting Ltd | Professional & scientific | 2024 |
| Spencer Structures Ltd | Construction | 2019 |
| Spencer Wire Products Limited | Manufacturing | 1995 |
| Sperber Service Fuer Haus, HOF UND Garten Limited | Administrative & support | 2006 |
| SPG Process Limited | Manufacturing | 2009 |
| SPG Solutions Limited | Construction | 2018 |
| SPH Civil Engineering Ltd | Construction | 2015 |
| Sphere Resources Ltd | Construction | 2018 |
| Spherical Search Ltd | Administrative & support | 2023 |
| Spia Limited | Health & social care | 2016 |
| Spice (Saltburn) Ltd | Hospitality | 2019 |
| Spiers Propco Ltd. | Real estate | 2019 |
| Spiers Psychology Ltd | Health & social care | 2022 |
| Spinal Injury Case Management Ltd | Health & social care | 2010 |
| Spong.Com Limited | Information & communication | 2000 |
| Sport and FUN Ltd | Education | 2023 |
| Sports Performance (Management) Limited | Arts & recreation | 2008 |
| Sportswift Limited | Wholesale & retail | 1998 |
| Spots Healthcare Ltd | Health & social care | 2022 |
| Spring Green Nurseries Limited | Wholesale & retail | 1976 |
| Springfields Convenience Store Ltd | Wholesale & retail | 2016 |
| Springwell Hardware Limited | Wholesale & retail | 2023 |
| Sprintex Limited | Wholesale & retail | 2013 |
| Sproc Solutions Limited | Information & communication | 2024 |
| SPS Storage Installations Ltd | Construction | 2017 |
| Sqta Qsza Limited | Transport & logistics | 2015 |
| Squadri Ltd | Health & social care | 2019 |
| Square ZEE Ltd | Wholesale & retail | 2020 |
| Squeaky Clean Hand Car Wash & Valeting Centre Ltd | Administrative & support | 2026 |
| Squeaky Clean Hand Car Wash Limited | Administrative & support | 2023 |
| Squery Ltd. | Professional & scientific | 2005 |
| Squirrelsinspace Ltd | Wholesale & retail | 2023 |
| SR Engineering Design Solutions Ltd | Professional & scientific | 2024 |
| SRB Medical Ltd | Health & social care | 2024 |
| SRB Software Ltd | Information & communication | 2020 |
| SRC Maintenance Limited | Construction | 2016 |
| Sreechandu Infotech Ltd | Information & communication | 2021 |
| Sreeven Properties Limited | Real estate | 2024 |
| Sreeven Solutions Limited | Information & communication | 2017 |
| SRI K Square Ltd | Wholesale & retail | 2019 |
| Srikrishna Capital Ltd | Real estate | 2026 |
| Srikuteer Properties Limited | Real estate | 2020 |
| SRJ Investments Limited | Real estate | 2019 |
| SRK Consulting Ltd | Information & communication | 2014 |
| SRK Prologistics Group Ltd | Transport & logistics | 2021 |
| SRM Energy Group Limited | Professional & scientific | 2014 |
| SRM Energy Holdings Limited | Energy | 2011 |
| SRM LP | | 2011 |
| SRS Service Program LP | | 2013 |
| SRW Properties Limited | Real estate | 2017 |
| SRZ Property Solutions Ltd | Construction | 2020 |
| SS Beds Ltd | Manufacturing | 2021 |
| Sscro Engineering Ltd | Professional & scientific | 2024 |
| SSF Properties Ltd | Real estate | 2017 |
| SSH Limited | Manufacturing | 1996 |
| Sshevill Engineering Ltd | Manufacturing | 2026 |
| SSM Consultancy Services Ltd | Administrative & support | 2015 |
| SSM Legal Services Limited | Administrative & support | 2022 |
| SSP Lupset Ltd | Wholesale & retail | 2025 |
| SSV Consultancy(Uk) Ltd | Health & social care | 2020 |
| ST Barts Holdings Limited | Real estate | 2018 |
| ST Clare Health Care Limited | Health & social care | 2022 |
| ST Clare Logistics Limited | Transport & logistics | 2026 |
| ST George's Lupset Ltd | Education | 1999 |
| ST Gregory Holdings Ltd | Financial services | 2018 |
| ST Holdings (Yorkshire) Limited | Real estate | 2025 |
| ST James (Becketwell) Limited | Real estate | 2020 |
| ST James Playcare Limited | Health & social care | 2013 |
| ST James Securities Group Limited | Real estate | 2015 |
| ST James Securities Limited | Real estate | 2005 |
| ST John's House Management Company Limited | Real estate | 2011 |
| ST Talent Ltd | Administrative & support | 2026 |
| ST. Faiths Manor Management Company Limited | Households | 2015 |
| ST. John's Square Management Company Limited | Households | 1987 |
| ST. Peters Flats Management (Horbury) Ltd | Households | 1997 |
| Staaarz Ltd | Transport & logistics | 2025 |
| Stacey's Bibs Ltd | Manufacturing | 2017 |
| Stage My Home Limited | Wholesale & retail | 2025 |
| Stagefold Facilities Limited | Arts & recreation | 2026 |
| Staim Collective Ltd | Wholesale & retail | 2023 |
| Staircase Installation Services Ltd | Construction | 2023 |
| Stakes & Hartley Limited | Administrative & support | 2010 |
| Stall Expo International Limited | Administrative & support | 2017 |
| Stallion Properties Limited | Real estate | 2018 |
| Stam and Maria Greek Corner Cafe Ltd | Hospitality | 2019 |
| Stamberg Autos Limited | Wholesale & retail | 2013 |
| Stamford Geomatics Limited | Administrative & support | 2006 |
| Stamps by ME Limited | Arts & recreation | 2014 |
| Standbridge Lane Community Development Trust | Other services | 2012 |
| Standin’ About Ltd | Wholesale & retail | 2025 |
| Stanhope Fields Residents Management Company Limited | Households | 2025 |
| Staniforths Motor Cycles (Wholesale) Limited | Wholesale & retail | 1973 |
| Stanjose Business Limited | Administrative & support | 2014 |
| Stanmore Management Company Limited | Real estate | 2008 |
| Stantons (Leeds) PVT Limited | Wholesale & retail | 1998 |
| Star (Wakefield) Ltd | Hospitality | 2024 |
| Star and Hill Ltd | Professional & scientific | 2024 |
| Star Bereavement and Support Service Limited | Health & social care | 2006 |
| Star Bounce (UK) Ltd | Administrative & support | 2017 |
| Starboard ITC Ltd | Information & communication | 2024 |