| Sara's Aesthetic Clinic Ltd | Other services | 2022 |
| Sarah Dykes (2013) Ltd | Administrative & support | 2013 |
| Sarah Elizabeth Creative Ltd | Information & communication | 2016 |
| Sarah Henry Safeguarding Consultancy Ltd | Wholesale & retail | 2020 |
| Sarah Holmes Ltd | Administrative & support | 2013 |
| Sarah Laud Design Ltd | Professional & scientific | 2023 |
| Sarah Vause Consulting Limited | Professional & scientific | 2025 |
| Sarcastic Science Club | Professional & scientific | 2018 |
| Sardar Traders Ltd | Wholesale & retail | 2023 |
| Sarl Sipcom Ltd | Information & communication | 2019 |
| Sarwar Property Holdings Limited | Households | 2022 |
| Sarwar Property Management Ltd | Real estate | 2025 |
| Sarwat Properties Ltd | Real estate | 2026 |
| SAS Sameday Limited | Transport & logistics | 2026 |
| Sasha FOX Media Ltd | Professional & scientific | 2024 |
| Sashes N Covers Venue Styling LLP | | 2012 |
| Satevis Ltd | Manufacturing | 2020 |
| Sathya Private Ltd | Health & social care | 2023 |
| Saturn Holdco Limited | Manufacturing | 2026 |
| Satzer Consulting Service Ltd. | Financial services | 2021 |
| Sauled Ltd | Construction | 2024 |
| Saver Spot Ltd | Wholesale & retail | 2024 |
| Savlec Limited | Manufacturing | 2016 |
| Savvy Options UK Limited | Other services | 2015 |
| Savvyture Ltd | Professional & scientific | 2016 |
| Sawe Healthcare Ltd | Health & social care | 2025 |
| Sawmill Timber UK Ltd. | Administrative & support | 2013 |
| SB Beds Ltd | Manufacturing | 2024 |
| SB Wraps and Graphics Ltd | Other services | 2018 |
| SBC Business Support Services Limited | Professional & scientific | 2022 |
| SBI Consultancy Yorkshire Ltd | Professional & scientific | 2024 |
| SBL Machinery Taiwan (UK) Ltd | Wholesale & retail | 2019 |
| Sbofitness Limited | Arts & recreation | 2024 |
| SBW Project Services Limited | Professional & scientific | 2025 |
| Scaeva Group Ltd | Construction | 2018 |
| Scarlet Bricks Ltd | Real estate | 2021 |
| SCG Verlag Limited | Information & communication | 2008 |
| Schitik @ Systems Geschaeftsfuehrung Limited | Professional & scientific | 2016 |
| Schneider Investments Ltd | Real estate | 2025 |
| Schofield & Sims Limited | Information & communication | 1901 |
| Scholefield a Ltd | Professional & scientific | 2015 |
| School Improvement Initiative Limited | Education | 2016 |
| School Speakers Enterprise Ltd | Administrative & support | 2012 |
| School-Led Development Trust | Education | 2021 |
| Schraag Limited | Professional & scientific | 2006 |
| Schutz Ltd. | Professional & scientific | 2005 |
| Schweizer Immobilien Treuhand Limited | Real estate | 2001 |
| Schwielowsee-Camping Ltd. | Hospitality | 2018 |
| SCL Administration Limited | Administrative & support | 2012 |
| SCN Holding Co Limited | Financial services | 2020 |
| Scoffit and Scarper Ltd | Hospitality | 2019 |
| Scot Telecom Limited | Information & communication | 2001 |
| Scott Asset Management Solutions Limited | Professional & scientific | 2018 |
| Scott Banks Hairdressing Ltd | Other services | 2001 |
| Scott Property Development Limited | Real estate | 1990 |
| Scrappy Bars 2024 Limited | Hospitality | 2024 |
| SCS Building Solutions Limited | Construction | 1994 |
| SCS Group Holdings Limited | Professional & scientific | 2018 |
| SCS Real Estate Management Limited | Administrative & support | 2008 |
| SCS Special Projects Limited | Construction | 2001 |
| SD Booze Blitz Limited | Wholesale & retail | 2018 |
| SD Project Management Limited | Professional & scientific | 2018 |
| SD Roofing (Yorkshire) Limited | Construction | 2021 |
| SD Socials Ltd | Other services | 2025 |
| SD Walton Electrical Ltd | Construction | 2026 |
| SD Yacht Service Ltd. | Professional & scientific | 2014 |
| SDB Civils Ltd | Construction | 2026 |
| Sdev Limited | Information & communication | 2008 |
| SDH Pipefitters Ltd | Construction | 2010 |
| Sdiv Ltd | Health & social care | 2026 |
| SDL Door Repairs & Installations Limited | Manufacturing | 2014 |
| SDL Properties (Yorkshire) Limited | Real estate | 2017 |
| SDM Tree Services Limited | Administrative & support | 2015 |
| SDW Plumbing & Heating Limited | Construction | 2007 |
| SDW Supplies Limited | Financial services | 2023 |
| Sea to Sky Meeting Management Ltd. | Administrative & support | 2006 |
| Seacroft Pharma Limited | Wholesale & retail | 2025 |
| Seahorse Electrical Services Limited | Construction | 2008 |
| Search Accountancy Limited | Professional & scientific | 2018 |
| Seasons in a JAR Ltd | Wholesale & retail | 2015 |
| Seasonsnap Ltd. | Information & communication | 2025 |
| Seatableuk Ltd | Manufacturing | 2020 |
| Sebpharm Limited | Wholesale & retail | 2006 |
| SEC Delivery Ltd | Professional & scientific | 2026 |
| Seckar KOI Ltd | Agriculture & fishing | 2026 |
| Seckar Ltd | Construction | 2022 |
| Second Chance Headway Centre | Health & social care | 2006 |
| Secret Door Events Ltd | Arts & recreation | 2025 |
| Secrieru Construction Ltd | Construction | 2018 |
| Sector Joinery and Services Ltd | Construction | 2024 |
| Secure Platform Solutions Ltd | Information & communication | 2018 |
| Securi-Fire Ltd | Administrative & support | 2026 |
| Securian Group Limited | Financial services | 2018 |
| Securian Industries Limited | Administrative & support | 2018 |
| Security Drone Group Ltd | Administrative & support | 2025 |
| SEE Sporty BE Sporty CIC | Education | 2020 |
| Seed Property Limited | Construction | 2023 |
| Seem Enterprise Ltd | Real estate | 2023 |
| Seen & Heard Therapy Limited | Health & social care | 2020 |
| Segnovate Ltd | Information & communication | 2024 |