| S&A Peters Properties Ltd | Extraterritorial | 2024 |
| S&Aj Properties Ltd | Real estate | 2026 |
| S&H Roberts Properties Ltd | Real estate | 2025 |
| S&K UK Services Ltd | Transport & logistics | 2020 |
| S&T Europe Limited | Administrative & support | 2009 |
| S-Tier Transport Ltd | Transport & logistics | 2025 |
| S. K. Family Property Investments Ltd. | Real estate | 2017 |
| S. Lattimer Projects Ltd | Professional & scientific | 2023 |
| S. R. Trees Ltd | Administrative & support | 2022 |
| S. Rickson Limited | Wholesale & retail | 1975 |
| S.C. Williams Limited | Administrative & support | 2003 |
| S.D. Tennant Limited | Wholesale & retail | 2002 |
| S.F.Goddard Ltd | Transport & logistics | 2024 |
| S.I.S Eurocapital Limited | Administrative & support | 2015 |
| S.R.M Decorators Ltd | Construction | 2019 |
| S.W & A.T (Holdings) Limited | Other services | 2019 |
| S2A Competitions Ltd | Wholesale & retail | 2024 |
| S2S Holdings Limited | Real estate | 2024 |
| S2UDENT Central Ltd | Education | 2021 |
| S3 Assets Ltd | Real estate | 2025 |
| S7G Ltd | Professional & scientific | 2019 |
| SA Calma Investments Limited | Real estate | 2024 |
| SA Health and Safety Ltd | Education | 2016 |
| Saak Auto Parts Manufacturing Limited | Administrative & support | 2025 |
| Saapae Consulting Limited | Financial services | 2015 |
| Saathee Limited | Administrative & support | 2022 |
| Sabra Limited | Construction | 2024 |
| Sabratha Limited | Health & social care | 2009 |
| Sabre Construction Ltd | Construction | 2020 |
| Sabre Law Limited | Professional & scientific | 2018 |
| Saddler Limited | Real estate | 2021 |
| Sadie Clayton Limited | Manufacturing | 2014 |
| Sadlers Cooked Meats Limited | Wholesale & retail | 2002 |
| SAE Estates Ltd | Real estate | 2018 |
| Safans Ltd | Wholesale & retail | 2021 |
| Safe and Sound Hearing Care Ltd | Health & social care | 2016 |
| Safe Facilities Management Ltd | Administrative & support | 2014 |
| Safe Haven Healthcare Services Ltd | Administrative & support | 2024 |
| Safety Incorporated Ltd | Administrative & support | 2023 |
| Safety Platforms Holdings Limited | Financial services | 2019 |
| Safety Platforms Limited | Wholesale & retail | 2003 |
| Safety Training (Yorks) Ltd | Professional & scientific | 2013 |
| SAH (UK) Limited | Health & social care | 2007 |
| SAH Properties Investments Ltd | Real estate | 2024 |
| Sahasra Solutions Limited | Hospitality | 2012 |
| SAI Vishnu Lettings Ltd | Real estate | 2020 |
| Saima Enterprise Ltd | Hospitality | 2023 |
| Saint John Developments Limited | Construction | 2023 |
| Saira & Sons Ltd | Real estate | 2013 |
| SAJ Management Ltd | Real estate | 2023 |
| Sajid Iqbal Limited | Administrative & support | 2014 |
| Saki Property Ltd | Real estate | 2025 |
| Salahudeen Ayyubi Mini Market Ltd | Wholesale & retail | 2024 |
| Salahudeen Ayyubi Store Ltd | Wholesale & retail | 2026 |
| Salam Halal Limited | Wholesale & retail | 2023 |
| Salihoglu Properties Ltd | Real estate | 2026 |
| Salis Consulting Limited | Professional & scientific | 2014 |
| Sally Brookling Ltd | Professional & scientific | 2025 |
| Sally's Chinoy Kitchen Ltd | Hospitality | 2026 |
| Salmon Vale Consultancy Limited | Information & communication | 2015 |
| Salolily Health Ltd | Health & social care | 2022 |
| Salon Tracker Limited | Information & communication | 2008 |
| Sals Trading Ltd | Wholesale & retail | 2023 |
| Salti Aparel Ltd | Wholesale & retail | 2024 |
| SAM JJM Ltd | Hospitality | 2025 |
| Samaa Property Limited | Real estate | 2024 |
| Samadhi Enterprise Ltd | Professional & scientific | 2019 |
| Saminova Ltd | Wholesale & retail | 2025 |
| Sampla Analytics Limited | Administrative & support | 2017 |
| Samruddhi Ecom Ltd | Wholesale & retail | 2022 |
| Samson Harper Group Ltd | Real estate | 2015 |
| Samuel Deen CDO Logistics Ltd | Transport & logistics | 2018 |
| SAN Esprit Limited | Administrative & support | 2008 |
| SAN Leos NO Manches Limited | Hospitality | 2024 |
| Sanantone Limited | Other services | 2016 |
| Sanbau Media Ltd | Information & communication | 2025 |
| Sanctuary Aesthetics Academy Ltd | Other services | 2026 |
| Sanctuary Aesthetics and Nails Ltd | Other services | 2025 |
| Sandal Bowling Property Limited | Arts & recreation | 2005 |
| Sandal Castle Properties Limited | Real estate | 1986 |
| Sandal Chippy Woods Limited | Wholesale & retail | 2002 |
| Sandal Foods Ltd | Wholesale & retail | 2024 |
| Sandal Grange (Wakefield) Management Company Limited | Households | 2004 |
| Sandal Hall Close Management Limited | Professional & scientific | 1989 |
| Sandal IT Consulting Limited | Information & communication | 2014 |
| Sandal Motors (Huddersfield) Limited | Wholesale & retail | 2008 |
| Sandal Pagoda Limited | Real estate | 1994 |
| Sandal Property Company Limited | Real estate | 2015 |
| Sandal Security Services Ltd | Administrative & support | 1998 |
| Sandal Shopfitters Limited | Construction | 2006 |
| Sanders Geeson Limited | Professional & scientific | 2002 |
| Sandpit Studios Ltd | Information & communication | 2025 |
| Sandra Henderson Consulting Limited | Administrative & support | 2015 |
| Sandy Smith Agencies Limited | Wholesale & retail | 2003 |
| Sandy Walk Ltd | Real estate | 2017 |
| Sanford Court (Ossett) Management Company Limited | Real estate | 2005 |
| Sankatmochan Limited | Real estate | 2025 |
| Sanpro Production Limited | Manufacturing | 2004 |
| Santos Take Way Limited | Hospitality | 2025 |
| SAP Technical Solutions Limited | Information & communication | 2019 |