| Segundos WF Ltd | Hospitality | 2019 |
| Sekira Holding | Financial services | 2016 |
| SEL Business Services Limited | Administrative & support | 2013 |
| Select Cars of Wakefield Limited | Wholesale & retail | 2018 |
| Select Developments (Yorkshire) Limited | Construction | 2007 |
| Select Solid Surfaces Limited | Manufacturing | 2011 |
| Self Management Consulting Limited | Education | 2024 |
| Sell My Car Leeds Ltd | Wholesale & retail | 2023 |
| Seller FBA Prep Company Ltd | Transport & logistics | 2020 |
| Sellevate Ltd | Wholesale & retail | 2025 |
| Sellsmith Decorating Ltd | Construction | 2026 |
| Selphie Limited | Health & social care | 2014 |
| Selrach Ltd | Health & social care | 2025 |
| SEM Tecno Plus Ltd | Wholesale & retail | 2024 |
| Semi-Detached Inspiration Ltd | Information & communication | 2022 |
| Senior Graphics Limited | Manufacturing | 2010 |
| Senior Signs and Graphics Limited | Manufacturing | 2024 |
| Senmotic 1.0 Limited | Wholesale & retail | 2011 |
| Sensus Data Network Ltd. | Information & communication | 2007 |
| Sentai Professional Solutions Ltd | Information & communication | 2025 |
| Senyam Relocations Ltd | Real estate | 2022 |
| Sequoia Tree Limited | Wholesale & retail | 2023 |
| Serafin Investments Ltd | Real estate | 2024 |
| Seravis Health Group Ltd | Education | 2026 |
| Serene Residential Care Limited | Health & social care | 2019 |
| Serengeti Live Limited | Hospitality | 2025 |
| Service & Trading Ltd. | Wholesale & retail | 2016 |
| Service MEN Limited | Administrative & support | 2019 |
| Servicemate (UK) Ltd | Information & communication | 2018 |
| Servicepunkt Vier Ltd | Construction | 2005 |
| Servicetas Limited | Administrative & support | 2015 |
| Setcubed Ltd | Professional & scientific | 2009 |
| Seyidaniels Consulting Ltd | Professional & scientific | 2026 |
| SF Global Retail Ltd | Wholesale & retail | 2026 |
| Sfhynx Ltd | Construction | 2018 |
| SG Building Design Ltd | Professional & scientific | 2010 |
| SG Process Consulting Ltd | Professional & scientific | 2018 |
| SGM Holdings Limited | Manufacturing | 2020 |
| SH Goraya Limited | Wholesale & retail | 2025 |
| SH Hydraulic Holdings Limited | Manufacturing | 2026 |
| SH7 Limited | Manufacturing | 2022 |
| Shabaz Properties Inc Ltd | Real estate | 2024 |
| Shackleton Duke Creative Limited | Administrative & support | 2014 |
| Shades Decorators Limited | Construction | 2002 |
| Shah JI WFD Limited | Hospitality | 2021 |
| Shahoanv Ltd | Transport & logistics | 2026 |
| Shajish Retail Ltd | Real estate | 2024 |
| Shakespeare Property & Rentals Ltd | Real estate | 2024 |
| Shakoor & Co Properties Limited | Real estate | 2012 |
| Shakoor Lettings Ltd | Real estate | 2016 |
| Shakoor Technology Consulting Ltd | Information & communication | 2025 |
| Shakoor.Group Ltd | Real estate | 2024 |
| Shakwan Mahmud Ltd | Financial services | 2025 |
| Shalestone Property & Investment Ltd | Real estate | 2024 |
| Shamaila Healthcare Ltd | Health & social care | 2020 |
| Shanbran Ltd | Hospitality | 2023 |
| Shancocsm Ltd | Wholesale & retail | 2020 |
| Shannu Limited | Wholesale & retail | 2023 |
| Shans Properties Ltd | Real estate | 2026 |
| Shaping the Future Ltd | Health & social care | 2015 |
| Sharlston Fisheries Jaye Ltd | Hospitality | 2024 |
| Sharlston Local KP Limited | Wholesale & retail | 2011 |
| Sharma Optical Limited | Health & social care | 2018 |
| Sharman Developments Limited | Construction | 2018 |
| Sharon House Enterprises Limited | Professional & scientific | 2010 |
| Sharon House Publishing Ltd | Arts & recreation | 2003 |
| Sharp Accountants Limited | Professional & scientific | 2010 |
| Sharp Coordination Ltd | Professional & scientific | 2013 |
| Sharpe BI Solutions Limited | Administrative & support | 2012 |
| Sharpe Investments & Holdings Ltd. | Financial services | 2022 |
| Sharpy TM Ltd | Construction | 2025 |
| Shaun Mccluskie (Engineering) Ltd | Construction | 2014 |
| Shaun Pugh Photography Limited | Wholesale & retail | 2009 |
| Shawarma Boss Ltd | Hospitality | 2026 |
| Shawarma Wakefield Ltd | Hospitality | 2025 |
| Shawmedica Limited | Health & social care | 2013 |
| Shazron Estates Ltd | Real estate | 2023 |
| SHC Consulting Ltd | Information & communication | 2016 |
| Shears Investments Limited | Real estate | 2023 |
| Sheds 'N' More Limited | Wholesale & retail | 2022 |
| Sheds Online Limited | Manufacturing | 2022 |
| Sheen Consulting Ltd | Professional & scientific | 2024 |
| Sheen Doors Ltd | Manufacturing | 2013 |
| Sheen Projects Limited | Construction | 2005 |
| Sheen UK Limited | Administrative & support | 2007 |
| Shef Investment Group Ltd | Hospitality | 2025 |
| Sheff Investments Ltd | Hospitality | 2025 |
| Shelbrook Property Ltd | Real estate | 2023 |
| Shen Consulting Services Limited | Professional & scientific | 2025 |
| Shenshah Tandoori Takeaway Limited | Hospitality | 2024 |
| Shepards Arms (Yorkshire) Limited | Hospitality | 2024 |
| Shepley Management Company Ltd | Households | 2016 |
| Shere Khan (ST Helens) Limited | Hospitality | 2010 |
| Shergill Contract Management Limited | Construction | 2013 |
| Sheridan Joinery (Wakefield) Limited | Construction | 2008 |
| Sheridan Property Developments Limited | Extraterritorial | 2007 |
| Sherlock Estates Ltd | Real estate | 2019 |
| Sherni Grazing Ltd | Hospitality | 2026 |
| Shersun Healthcare Limited | Extraterritorial | 2015 |
| Sheryar Locums Limited | Health & social care | 2022 |