| Senior Comms Limited | Administrative & support | 2017 |
| Septavon Limited | Other services | 2023 |
| Sequoia Builders Ltd | Construction | 2025 |
| Serene Skin Solutions Limited | Other services | 2025 |
| Service D'Preparation Limited | Construction | 2008 |
| SET Waves Ltd | Arts & recreation | 2023 |
| SEV1973 Limited | Hospitality | 2022 |
| Sevenex Limited | Transport & logistics | 2025 |
| Seymour & Co (Bristol) Ltd | Real estate | 2019 |
| Seymour Court (Totnes) Management Limited | Hospitality | 1983 |
| Shahnaz Diner Limited | Hospitality | 2011 |
| Shaka Industries Limited | Manufacturing | 2018 |
| Shali House UK Limited | Real estate | 2025 |
| Shangri-La Business Solutions Ltd | Wholesale & retail | 2021 |
| Shapes and Shadows Ltd | Professional & scientific | 2023 |
| Shapley TOR Ltd | Real estate | 1957 |
| Sheep Market Hill Ltd | Other services | 2020 |
| Sheirin Makkar Limited | Health & social care | 2021 |
| Sheridan House (Newton Abbot) Management Company Limited | Professional & scientific | 2004 |
| Shervey Projects International Limited | Transport & logistics | 2025 |
| Shiftie Software Ltd | Information & communication | 2022 |
| Shiphay Motors Ltd | Wholesale & retail | 2025 |
| Shirley Towers (Management) Company Limited | Households | 1985 |
| Shoeshine Property Investments Limited | Real estate | 2017 |
| Shore Point Property Management Limited | Households | 2001 |
| Shoreline Translations Limited | Administrative & support | 2008 |
| Shortland Plumbing & Heating Ltd | Construction | 2026 |
| Sian Davey Photography Ltd | Professional & scientific | 2017 |
| Sidings Limited | Real estate | 2009 |
| Sidwell Street Management Company Limited | Households | 2007 |
| SIE Consulting Ltd | Extraterritorial | 2015 |
| Sienna Editions Ltd | Wholesale & retail | 2025 |
| Sierra Flight Limited | Administrative & support | 2022 |
| Silent Motor Company Limited | Professional & scientific | 2023 |
| Silent Roof Ltd | Construction | 2018 |
| Silverbolt Security Ltd | Construction | 2026 |
| Silverzone Collection Ltd | Wholesale & retail | 2014 |
| Silvester's Building & Heating Services Limited | Construction | 2009 |
| Simcock Biostatistics Consultant Ltd | Professional & scientific | 2025 |
| Simon Court (Torquay) Limited | Households | 2022 |
| Simon Watson Leisure Ltd | Hospitality | 2025 |
| Simply Compliance Limited | Administrative & support | 2004 |
| Simply Efficient Transport Limited | Transport & logistics | 2022 |
| Simply Fish (Brixham) Limited | Extraterritorial | 2013 |
| Simply Roka Ltd | Wholesale & retail | 2016 |
| Simplyderma Ltd | Other services | 2014 |
| Simwise Media Limited | Administrative & support | 2020 |
| Sirenz Security Systems Limited | Administrative & support | 2020 |
| Site & Holmes Ltd | Water & waste | 2024 |
| Site & Holmes Property's Ltd | Real estate | 2026 |
| Site UK Welding, Fabrication and Installation Ltd | Manufacturing | 2013 |
| SIX Sigma Financials Limited | Professional & scientific | 2025 |
| SJ Patents Ltd | Professional & scientific | 2019 |
| SJB Electrical SW Ltd | Energy | 2014 |
| Skandha Gynaecology Practice Limited | Health & social care | 2011 |
| SKI Torquay Ltd | Arts & recreation | 2021 |
| Skjrw Limited | Real estate | 2023 |
| Skull Labs Premium E-Juice Ltd | Manufacturing | 2016 |
| Skyline Healthcare Solutions Ltd | Public administration | 2023 |
| Sleydean Limited | Hospitality | 1978 |
| Slim Design and Print Ltd | Information & communication | 2013 |
| SLP (Devon) Limited | Hospitality | 2021 |
| SM Power (SW) Ltd | Construction | 2019 |
| Smart Car Wash Equipment & Supplies Ltd. | Wholesale & retail | 2017 |
| Smart Car Wash Ltd | Other services | 2013 |
| Smart Glass Solutions Ltd | Construction | 2022 |
| SMH Property Investments Ltd | Real estate | 2025 |
| Smile Barry Ltd | Energy | 2024 |
| Smile Direct Limited | Extraterritorial | 2014 |
| Smith PE Lettings Ltd | Real estate | 2026 |
| SMN Developments Ltd | Construction | 2024 |
| SMW Roofing Limited | Construction | 2006 |
| Snagaroo Limited | Professional & scientific | 2017 |
| Snailaway Limited | Construction | 2007 |
| Sneaky Gleam Cleaning Ltd | Administrative & support | 2023 |
| SNO Solutions Ltd | Administrative & support | 2025 |
| Snow Goose Productions Limited | Arts & recreation | 2006 |
| Soady Construction Ltd | Construction | 2026 |
| Soak Lifestyle Ltd | Hospitality | 2023 |
| Soapslurp Ltd | Information & communication | 2022 |
| Societe Copage Ltd | Professional & scientific | 2015 |
| Societe D'Osteopathie Chalonnaise Limited | Health & social care | 2023 |
| Softbay Properties Limited | Households | 1990 |
| Solar Integration Ltd | Other services | 2022 |
| Solian Limited | Professional & scientific | 2006 |
| Somerset Fresh Limited | Wholesale & retail | 2010 |
| Somerville & Savage Solicitors | Administrative & support | 2000 |
| Songhai Africa Research Group Limited | Professional & scientific | 2025 |
| Sonic Court Management Limited | Real estate | 2003 |
| Sonny Property Ltd | Real estate | 2017 |
| Sonny RAE (Torquay) Management Company Limited | Households | 2026 |
| Sorrento Management Association Limited | Households | 1982 |
| Sorted. Building & Maintenance Solutions Ltd | Construction | 2026 |
| SOS Consultancy Limited | Information & communication | 1998 |
| SOS Consultancy Services Limited | Extraterritorial | 2022 |
| SOS Property Services Ltd | Real estate | 2022 |
| Soul Meets Body Collective Ltd | Wholesale & retail | 2026 |
| Soulsupply Ltd | Wholesale & retail | 2024 |
| South Court (Torquay) Property Management Company Limited | Households | 2010 |
| South Devon DAB Ltd | Information & communication | 2022 |