| South Devon Flat Roofing Limited | Construction | 2002 |
| South Devon Football League | Arts & recreation | 2022 |
| South Devon Gastro Limited | Health & social care | 2019 |
| South Devon Homes Limited | Construction | 2020 |
| South Devon Radio 102 CIC | Information & communication | 2025 |
| South Devon Radio DAB Limited | Information & communication | 2022 |
| South Devon Tyres Limited | Wholesale & retail | 2025 |
| South Devon Vehicle Installations Ltd | Manufacturing | 2026 |
| South Devon Vending Limited | Wholesale & retail | 1994 |
| South Eden Property Management Company Limited | Hospitality | 2022 |
| South Gate Lamb South Limited | Households | 2008 |
| South Hams Motor Company Limited | Construction | 2003 |
| South Hams Renovation Ltd | Construction | 2026 |
| South West Boat Club Ltd | Arts & recreation | 2022 |
| South West Car and Commerical Ltd | Transport & logistics | 2025 |
| South West Commissioning Services Limited | Professional & scientific | 2009 |
| South West Construction Contractors Ltd | Construction | 2025 |
| South West Creative CIC | Arts & recreation | 2025 |
| South West Family Law Limited | Professional & scientific | 2015 |
| South West Foot and Ankle Limited | Health & social care | 2009 |
| South West Independent Children's Services Limited | Health & social care | 2012 |
| South West Land Surveys Limited | Professional & scientific | 2013 |
| South West Leisure Holdings Limited | Hospitality | 2017 |
| South West Parts Ltd | Wholesale & retail | 2023 |
| South West Plumbing Services Limited | Construction | 2003 |
| South West Trawlers Ltd | Agriculture & fishing | 2015 |
| Southam Fields Exeter Limited | Households | 2006 |
| Southernhay (Teignmouth) Management Company Limited | Households | 2018 |
| Southernhay Clinic Ltd | Professional & scientific | 2004 |
| Southernwood Nursery Limited | Education | 2013 |
| Southgate Interiors Ltd | Construction | 2025 |
| Southwest Properties Plus Ltd | Real estate | 2025 |
| Southwood Court (Torquay) Association Limited | Households | 1961 |
| Sovereign House Torquay Management Company Limited | Households | 2006 |
| Spa Villa Limited | Households | 2016 |
| Space and Time Removals Ltd | Transport & logistics | 2024 |
| Sparks Building Services Limited | Construction | 2008 |
| Spartan GAS and Heating Ltd | Construction | 2018 |
| Speare & Associates Ltd | Administrative & support | 2024 |
| Specialised Decorating Services Ltd | Construction | 2025 |
| Speciality Best Wishes Limited | Wholesale & retail | 2011 |
| Spectra Conservatory Roofs Limited | Manufacturing | 2002 |
| Spey Power Ltd | Administrative & support | 2012 |
| Spider Homes Limited | Real estate | 2024 |
| Spiked Extreme Limited | Professional & scientific | 2007 |
| Spindl CIC | Professional & scientific | 2022 |
| Spinford Ltd | Extraterritorial | 2021 |
| Splenius Sport Performance Consulting Limited | Other services | 2018 |
| Sport Torbay Limited | Arts & recreation | 2015 |
| Spotlight Property Staging Ltd | Construction | 2025 |
| Spotty Dog Coaching Limited | Professional & scientific | 2023 |
| Springhaven Property Management Limited | Households | 2016 |
| Springhill Residents Limited | Households | 2012 |
| Springwood Property Investment Ltd | Real estate | 2021 |
| Sprucecity Property Management Limited | Households | 1991 |
| SPS Consultancy (SW) Limited | Hospitality | 2008 |
| Spud Media Ltd | Manufacturing | 2023 |
| Square PIG Limited | Administrative & support | 2013 |
| Squires M Limited | Wholesale & retail | 2017 |
| SR & MP Trading Limited | Wholesale & retail | 2008 |
| SRP (Torquay) Limited | Extraterritorial | 2005 |
| SRP Accounts Limited | Professional & scientific | 2010 |
| ST Albans Mansion RTM Company Limited | Households | 2012 |
| ST Annes Court (Babbacombe) Limited | Households | 1986 |
| ST Annes Hall Babbacombe Limited | Arts & recreation | 2000 |
| ST Dominics Mews (Torquay) Management Company Limited | Households | 2026 |
| ST Faiths (Torquay) Limited | Real estate | 2001 |
| ST Helens (Wellswood) Management Company Limited | Households | 2026 |
| ST James' (Dawlish) Management Company Limited | Households | 2014 |
| ST Margaret's Academy | Education | 2011 |
| ST Marks Drive (Torquay) Management Company Limited | Households | 2006 |
| ST Marychurch Carpet & Flooring Ltd | Wholesale & retail | 2010 |
| ST Marychurch Foot Clinic Limited | Health & social care | 2013 |
| ST Marychurch Links Management Company Limited | Real estate | 2015 |
| ST Marychurch Research Limited | Health & social care | 2024 |
| ST Marychurch Trading Company Limited | Wholesale & retail | 2004 |
| ST Marys Bakery Paignton Limited | Wholesale & retail | 2021 |
| ST Ronans Property Management Company Limited | Real estate | 1994 |
| ST. Elmo Management Company Limited | Households | 1997 |
| ST. Margaret's Court (Topsham) Limited | Households | 1986 |
| ST. Margaret's Court (Torquay) Management Company Limited | Households | 1993 |
| ST. Marks and ST. Francis Management Company Limited | Households | 1992 |
| ST. Mary's Mews Management Limited | Households | 1999 |
| ST. Michaels House Management Company Limited | Households | 2002 |
| Stackyours Commerce Ltd | Wholesale & retail | 2024 |
| Stairway Coaching Limited | Other services | 2014 |
| Stancott Homes Limited | Construction | 2022 |
| Stanfield Residents' Association Limited | Households | 1973 |
| Stanley Medical 2023 Limited | Health & social care | 2023 |
| Stanscape Limited | Administrative & support | 2020 |
| Stanton Beech Farm Limited | Agriculture & fishing | 2013 |
| Stapleton House Torquay Management Company Limited | Households | 1991 |
| Starlash Beauty Salon Limited | Other services | 2018 |
| Starlash Training Academy Limited | Education | 2018 |
| Station Garage (Totnes) Limited | Wholesale & retail | 2003 |
| Stawtrent Limited | | 1983 |
| STE Tonnellier Carrieres Limited | Construction | 2005 |
| Steel Innovation Limited | Construction | 2004 |
| Steel Services Associates Limited | Manufacturing | 1994 |
| Steg Limited | Other services | 2008 |