| S D K (Environmental) Limited | Health & social care | 2000 |
| S Davis Investments Limited | Financial services | 2019 |
| S E Bellamy Limited | Administrative & support | 2018 |
| S T Services Plumbing and Heating Limited | Construction | 2003 |
| S&A Gandev Ltd | Wholesale & retail | 2023 |
| S&I Logistics Limited | Transport & logistics | 2025 |
| S&S Roofing SW Ltd | Construction | 2025 |
| S. T Gemeaux Limited | Other services | 2015 |
| S.A.Warner and Co.Limited | Real estate | 1925 |
| S.Lambe Plumbing & Heating Ltd | Construction | 2024 |
| S.M and A.M Rentals Ltd | Real estate | 2026 |
| S.M.R. Natural Slate Roof Company Limited | Construction | 1978 |
| S.P.D. (SW) Limited | Real estate | 2019 |
| S.West Limited | Health & social care | 2024 |
| SA Brothers Group Ltd | Administrative & support | 2025 |
| SA Construct Ltd | Construction | 2023 |
| SA Property WSM Limited | Real estate | 2022 |
| Saab Master Service & Repairs Ltd | Wholesale & retail | 2015 |
| Safe Space Services Limited | Administrative & support | 2026 |
| Safe-Ways Torbay C.I.C. | Health & social care | 2022 |
| Saint Elmo Fire Limited | Wholesale & retail | 2020 |
| Salcombe Consulting Ltd | Professional & scientific | 2020 |
| Salcombe Finest Limited | Hospitality | 2011 |
| Salisbury Mews RTE Company Limited | Households | 2005 |
| Saltwaves Ltd | Information & communication | 2012 |
| Samjen Properties Limited | Real estate | 2023 |
| Samsonhca Limited | Public administration | 2023 |
| Samuel Barbara Developments Limited | Construction | 1999 |
| Sand Martins (Newton Abbot) Limited | Real estate | 2008 |
| Sandhurst Court (Torquay) Management Company Limited | Households | 2000 |
| Sandown Court (Torquay) Management Company Limited | Real estate | 1996 |
| Sani Tech South West Ltd | Construction | 2021 |
| Sani-Tech Devon Ltd | Construction | 2019 |
| Sapphire Cars Torbay Ltd | Wholesale & retail | 2023 |
| Sara Loiperdinger Ltd | Professional & scientific | 2018 |
| Sarah Pearse Ltd | Information & communication | 2013 |
| Sasi Collective Limited | Information & communication | 2026 |
| Saso Ltd | Information & communication | 2014 |
| Saunders Stores Limited | Wholesale & retail | 2012 |
| Savage Scaffolding Ltd | Construction | 2019 |
| Sawasdeeservices Ltd | Administrative & support | 2024 |
| Saxton Vincent Ltd | Professional & scientific | 2025 |
| Saxxon Group Ltd | Other services | 2016 |
| SB Housing (South West) Limited | Real estate | 2019 |
| SB2A Group Limited | Information & communication | 2020 |
| SBS Altan Ltd | Other services | 2023 |
| Sbsc Ltd | Health & social care | 2002 |
| SBT Enterprises Ltd | Information & communication | 2019 |
| Scancoming Limited | Administrative & support | 1976 |
| Sccompetitions Limited | Other services | 2023 |
| Sceptre Surveyors Limited | Professional & scientific | 2019 |
| Scgm Limited | Administrative & support | 2025 |
| Schlub Developments Ltd | Real estate | 2021 |
| Schoollife Group Ltd | Education | 2025 |
| Scoot Fest Limited | Other services | 2011 |
| Scorer Property Services Limited | Real estate | 2003 |
| Scoring Goals Limited | Financial services | 2023 |
| Scott Group Capital Limited | Real estate | 2025 |
| Scottleigh Management Company (Torquay) Limited | Households | 1997 |
| Scoulding Quantity Surveying Ltd | Professional & scientific | 2008 |
| Scruffs (Maidenhead) Limited | Agriculture & fishing | 2019 |
| SCS Scaffolding SW Ltd | Construction | 2018 |
| SCW South West Ltd | Administrative & support | 2025 |
| SD Fire Ltd | Wholesale & retail | 2023 |
| Sdavies T/A SD Plumbing & GAS Ltd | Professional & scientific | 2024 |
| SDH Developments Limited | Wholesale & retail | 2013 |
| SDM Capital Ltd | Real estate | 2024 |
| Sea Lady Limited | Administrative & support | 2012 |
| Sea Pro France Limited | Administrative & support | 2010 |
| Sea Tang Limited | Hospitality | 2016 |
| Seaborne Court (Management) Limited | Households | 1988 |
| Seacliff (Teignmouth) Limited | Real estate | 2003 |
| Seacliff Management Company (Torquay) Limited | Households | 2002 |
| Seafield Investments Limited | Real estate | 2015 |
| Seaford Sands Management Company Limited | Real estate | 2015 |
| Seafront Cafe Ltd | Hospitality | 2024 |
| Seafront Villa Ltd | Hospitality | 2022 |
| Seaglass Creative Ltd | Information & communication | 2025 |
| Seagull House (Management) Limited | Households | 2007 |
| Sean Mcardle & SON Limited | Construction | 2015 |
| Seashore Consultancy Ltd | Professional & scientific | 2024 |
| Seasonal Surprises Ltd | Wholesale & retail | 2024 |
| Seaview Torquay Ltd | Hospitality | 2021 |
| Seaway (Torquay) Management Limited | Households | 2006 |
| Seaway Court (Torquay) Limited | Households | 1973 |
| Seaway Holdings Limited | Financial services | 2015 |
| Seaway Royale Limited | Manufacturing | 2018 |
| Second Frog Limited | Administrative & support | 2012 |
| Second Time Around Furniture Ltd | Wholesale & retail | 2020 |
| Secrets From the Grave Ltd | Information & communication | 2025 |
| Secur-A-Door Limited | Construction | 2006 |
| Sede Holdings Limited | Health & social care | 2022 |
| Sedgemoor Drinks Limited | Extraterritorial | 2019 |
| Sefton Court (Torquay) Management Limited | Households | 1978 |
| Seighford Lakes Wind Turbine Limited | Energy | 2022 |
| SEJ Property (SW) Limited | Real estate | 2023 |
| Select Inns (SW) Ltd | Hospitality | 2019 |
| Selfie Scan Limited | Health & social care | 2024 |
| Seller Frontier LLP | | 2018 |
| Senate Investments (Devon) Limited | Real estate | 2021 |