| Scarab Sweepers Limited | Manufacturing | 1984 |
| Scaramanga Communications Limited | Professional & scientific | 2010 |
| Scarecrow Intelligence Ltd | Information & communication | 2025 |
| Scec Electrical Contractors Ltd | Construction | 2026 |
| Schaedel Psychology Limited | Professional & scientific | 2022 |
| School Counselling Ltd | Education | 2023 |
| School Health Check Ltd | Health & social care | 2020 |
| School of Bronchoscopy Ltd | Health & social care | 2023 |
| Schools Supported Ltd | Education | 2023 |
| Schwartz Hansen Ltd | Professional & scientific | 2024 |
| SCM ENT Ltd | Health & social care | 2019 |
| Scotchnbonnet Ltd | Hospitality | 2025 |
| Scott Communications (U.K.) Ltd | Information & communication | 2018 |
| Scott Consulting Group Limited | Professional & scientific | 2021 |
| Scotts Project Trust | Health & social care | 1996 |
| Scrambled Leggs Running Ltd | Arts & recreation | 2024 |
| Scratton Properties LLP | | 2012 |
| Scrub Games Ltd | Education | 2022 |
| Scruff Films Ltd | Information & communication | 2019 |
| Scrumptious Digital Ltd | Professional & scientific | 2024 |
| Scrunchies by NAT Ltd | Manufacturing | 2022 |
| SCS Bridgehouse Limited | Real estate | 2018 |
| Scuk Ltd | Professional & scientific | 2017 |
| Scyldings IT UK Limited | Information & communication | 2022 |
| SD & RC Enterprises Ltd | Administrative & support | 2020 |
| Sdbcm Limited | Construction | 2023 |
| SE Groundworks Ltd | Construction | 2018 |
| Seaford Ford Ltd | Extraterritorial | 2012 |
| Seal Chart Media Ltd | Information & communication | 2022 |
| Sealclean (Tonbridge) LLP | | 2008 |
| Sean Flanagan Ltd | Information & communication | 2022 |
| Seaneyes Optical Services Ltd | Health & social care | 2015 |
| Seaton Place Management Company Limited | Households | 2001 |
| Sebastien Kwok London Ltd | Wholesale & retail | 2020 |
| Sebastopol Investments Ltd | Professional & scientific | 2014 |
| Secure IT Locks on Vans Ltd | Professional & scientific | 2024 |
| SEE ALL the Sights Ltd | Administrative & support | 2024 |
| Seed Folk Ltd | Wholesale & retail | 2023 |
| Segrasa Limited | Construction | 2015 |
| Seido Art Services Ltd | Other services | 2020 |
| Seidov Ltd | Hospitality | 2024 |
| Selby Howard Limited | Professional & scientific | 2007 |
| Selec Services Ltd | Construction | 2020 |
| Select Technology Systems Limited | Information & communication | 1995 |
| Sellar Sparks Ltd | Construction | 2025 |
| Sellomni Limited | Information & communication | 2017 |
| Sensible Promotions Limited | Hospitality | 2000 |
| Sensible Wine Services Limited | Hospitality | 1994 |
| Sensory Living - Freedom and Growth Ltd | Health & social care | 2023 |
| Sensum Ltd | Information & communication | 2014 |
| Sentinel Safeguarding Ltd | Information & communication | 2026 |
| Seodra Limited | Wholesale & retail | 2010 |
| Septor Limited | Real estate | 2016 |
| Serendipity Developments Ltd | Real estate | 2019 |
| Serendipity Personalised Gifts Limited | Arts & recreation | 2025 |
| SES Pest Control Kent Ltd | Administrative & support | 2025 |
| Sesamecave Ltd | Wholesale & retail | 2023 |
| Sesamex Limited | Information & communication | 2000 |
| Session Workplace Ltd | Professional & scientific | 2025 |
| Settlers Honey UK Limited | Financial services | 2025 |
| Seven Elevation Ltd | Professional & scientific | 2012 |
| Sevenoaks Building Services Limited | Extraterritorial | 2004 |
| Sevenoaks Clothes House Limited | Wholesale & retail | 2025 |
| Sevenoaks Landscaping (Kent) Ltd | Administrative & support | 2008 |
| Sevenoaks Sports Publishing Limited | Information & communication | 2017 |
| Sevenoaks Window Cleaning Limited | Administrative & support | 2017 |
| Sevenoaks Windows and Doors Ltd | Construction | 2023 |
| Sevr Neurology Limited | Professional & scientific | 2024 |
| Seyit Catering Limited | Hospitality | 2017 |
| Seymour Respiratory Consultancy Limited | Health & social care | 2024 |
| SF Mihai Limited | Construction | 2024 |
| SG & Sons Electrical Ltd | Construction | 2019 |
| SG Contractors Ltd | Administrative & support | 2018 |
| SGT44 Limited | Professional & scientific | 2019 |
| SH Smart Repairs Limited | Wholesale & retail | 2013 |
| Shadow Wolf Limited | Professional & scientific | 2011 |
| Shandon Close Limited | Households | 2019 |
| Shanta's Kitchen Ltd | Hospitality | 2023 |
| Shaq/Architects Limited | Extraterritorial | 2005 |
| Share Disclosure Limited | Information & communication | 2018 |
| Sharm Invest Limited | Real estate | 2025 |
| Shashi Estates Ltd | Real estate | 2018 |
| SHC Engineering Services Ltd | Professional & scientific | 2026 |
| SHC Events Ltd | Arts & recreation | 2022 |
| SHED57 Limited | Extraterritorial | 2020 |
| Sheldon Medical Services Limited | Health & social care | 2023 |
| Shellness Estate Limited | Hospitality | 1977 |
| Shelton Close Flats Management Limited | Households | 1993 |
| Shenstone Consulting Limited | Professional & scientific | 2007 |
| Shepherds Farm Ltd | Real estate | 2024 |
| Sheree Atcheson Ltd | Information & communication | 2020 |
| Sherenden Park Management Company Limited | Real estate | 1987 |
| Sherlock Films Limited | Information & communication | 2020 |
| Shields Estates Limited | Real estate | 1982 |
| Shipborn Software Solutions Ltd | Information & communication | 2024 |
| Shipbourne Decorators Limited | Construction | 2004 |
| Shipward Management Services Limited | Households | 1973 |
| Shorncliffe Heights (Risborough Court) (Block B1) Residents Management Company Limited | Households | 2024 |
| Shorncliffe Heights (Risborough Court) (Block D) Residents Management Company Limited | Households | 2024 |
| Shorncliffe Heights (Risborough Court) (Blocks a & B4) Residents Management Company Limited | Households | 2024 |